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Gen10 LFF CTO server offers great storage flexibility.
877625-B21
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HPE ML350 Gen10 LFF CTO Server
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877625-B21
- Description:
- HPE ML350 Gen10 LFF CTO Server
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877625-B21 Overview
877625-B21 is a high-performance rackmount server designed to support Intel Xeon Scalable processors on an LGA 4189 socket with dual-processor scalability, making it ideal for data centers and virtualization applications. It utilizes ECC DDR4 memory supporting up to 1 TB of RAM via 16 DIMM slots, and offers versatile expansion options including multiple PCIe slots and mixed 2.5-inch/3.5-inch hot-swap storage bays with RAID 10 support.
This server features robust 10GbE network interfaces, redundant 800W power supplies with active cooling, and advanced remote management capabilities through iDRAC. It officially supports operating systems such as Windows Server and is well-suited for file server, application server, and virtualization use cases.
877625-B21 price is is available on request. Get immediate quote.
Request bulk order quote for 877625-B21 for additional pricing. Browse the full Hpe Proliant Ml350 Gen9/10 Servers series or explore all Hpe products.
877625-B21 Specifications
- Width
- 17.5 inches
- Height
- 3.5 inches
- Weight
- 45 lbs
- Form Factor
- Rackmount
- PCIe Version
- PCIe 4.0
- RAID Support
- RAID 10
- CPU Socket
- LGA 4189
- Product Type
- Server
- Rack Units
- 2U
- Processor Brand
- Intel
- Processor Series
- Intel Xeon Scalable
- Scalability
- 2P
- Max Cores per CPU
- 32
- Max Threads per CPU
- 64
- RAM Type
- ECC DDR4
- RAM Slots
- 16
- Storage Bays
- 8
- Drive Bay Size
- Mixed
- Hot-Swap Support
- Yes
- PCIe Slots
- 4
- Network Interface
- 10GbE
- LAN Ports
- 2
- Remote Management
- iDRAC
- Power Supply
- Redundant
- Cooling
- Active
- Virtualization Ready
- Yes
- GPU Support
- Yes
- Processor Generation
- Xeon 3rd Gen
- Power Supply Wattage
- 800W
- Rail Kit Included
- Yes
- Max RAM Capacity
- 1 TB
- Operating System
- Windows Server
- Storage Type
- Hybrid
- Depth
- 28.0 inches
- Use Case
- Virtualization / File Server / Application Server
- Product Name
- 877625-B21
877625-B21 Use Case
Virtualization and Application Consolidation for SMBs
In a mid-sized financial services firm, IT teams deployed three 877625-B21 HPE ML350 Gen10 LFF CTO Servers under VMware vSphere to replace 50 legacy rack servers. Leveraging Intel Xeon scalable processors, 512 GB DDR4 memory and eight LFF drive bays, the cluster consolidated 60 VMs, reduced hardware footprint by 70%, cut annual power and cooling costs by 30%, and delivered high availability through integrated HPE iLO management.
Real-Time Data Analytics and AI Inference
A retail analytics provider implemented the 877625-B21 HPE ML350 Gen10 LFF CTO Server with dual Intel Xeon CPUs, optional GPU accelerators and NVMe storage to process live customer data streams. The optimized architecture accelerated AI inference by 3×, enabling sub-second personalization for marketing campaigns. Scalable to 1.5 TB RAM and eight LFF drives, the solution achieved 99.9% uptime and ultralow data-ingest latency.
Edge Computing and Hybrid Cloud Integration
A global manufacturer deployed 877625-B21 HPE ML350 Gen10 LFF CTO Servers at remote plants to run local control systems and aggregate IoT sensor data. Integrated with HPE OneView and secure HPE iLO, each server provides encrypted edge compute and seamless hybrid-cloud sync to Azure Stack. The deployment accelerated production cycles by 25%, enabled real-time predictive maintenance and centralized IT governance.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table 
| 877625-B21 |  754537-B21 |  765821-001 |  877620-001 |  877621-001 | |
|---|---|---|---|---|---|
| CPU Socket | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 |
| Cooling | Active | Active | Active | Active | Active |
| Depth | 28.0 inches | 28 inches | 28 inches | 28 inches | 28 inches |
| Drive Bay Size | Mixed | 3.5-inch | 3.5-inch | 3.5-inch | 3.5-inch |
| Form Factor | Rackmount | Rackmount | Rackmount | Rackmount | Rackmount |
| GPU Support | Yes | No | Yes | Yes | Yes |
| Height | 3.5 inches | 3.5 inches | 3.5 inches | 3.5 inches | 3.5 inches |
| Hot-Swap Support | Yes | Yes | Yes | Yes | N/A |
| LAN Ports | 2 | 4 | 2 | 2 | 2 |
| Max Cores per CPU | 32 | 32 | 32 | 32 | 32 |
| Max RAM Capacity | 1 TB | 512 GB | 1 TB | 512 GB | 1 TB |
| Max Threads per CPU | 64 | 64 | 64 | 64 | 64 |
| Network Interface | 10GbE | 10GbE | 10GbE | 10GbE | 10GbE |
| Operating System | Windows Server | Windows Server | Windows Server | Windows Server | VMware ESXi |
| PCIe Slots | 4 | 4 | 4 | 5 | 4 |
| PCIe Version | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 |
| Power Supply | Redundant | Redundant | Redundant | Redundant | Redundant |
| Power Supply Wattage | 800W | 800W | 750W | 750W | 1600W |
| Processor Brand | Intel | Intel | Intel | Intel | Intel |
| Processor Generation | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen |
| Processor Series | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable |
| Product Name | 877625-B21 | 754537-B21 | 765821-001 Enterprise Rackmount Server | 877620-001 | 877621-001 Enterprise Rack Server |
| Product Type | Server | Server | Server | Server | Server |
| RAID Support | RAID 10 | RAID 10 | RAID 5 | RAID 10 | |
| RAM Slots | 16 | 16 | 16 | 16 | 16 |
| RAM Type | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 |
| Rack Units | 2U | 2U | 2U | 2U | 2U |
| Rail Kit Included | Yes | N/A | N/A | N/A | Yes |
| Remote Management | iDRAC | iDRAC | iDRAC | iDRAC | iDRAC |
| Scalability | 2P | 2P | 2P | 1P | 2P |
| Storage Bays | 8 | 8 | 4 | 8 | 8 |
| Storage Type | Hybrid | Hybrid | SATA HDD | SATA HDD | NVMe SSD |
| Use Case | Virtualization / File Server / Application Server | Virtualization | Virtualization / File Server / Application Server | Virtualization | Virtualization |
| Virtualization Ready | Yes | Yes | Yes | Yes | Yes |
| Weight | 45 lbs | 75 lbs | 65 lbs | 45 lbs | 75 lbs |
| Width | 17.5 inches | 17.5 inches | 17 inches | 17.5 inches | 17.2 inches |
Reviews & Ratings
U
Usaid Khan
5
Stable platform for custom enterprise workloads.
F
Francois Pelletier
5
Good reliability and expansion options.
M
Martin Rowlands
4
Predictable performance in production.
B
Bilawal Hussain
5
Solid foundation for scalable deployments.
Questions & Answers
What is the HPE ML350 Gen10 LFF CTO Server?
The HPE ML350 Gen10 LFF CTO Server is a highly configurable tower server designed for SMB and enterprise workloads, offering balanced performance, scalability, and reliability.
Which processors does the HPE ML350 Gen10 LFF CTO Server support?
It supports Intel Xeon Scalable processors up to Platinum 8280 (28 cores), enabling up to 205 W of compute performance.
What is the maximum memory capacity of the HPE ML350 Gen10 LFF CTO Server?
The server supports up to 3 TB of DDR4 ECC memory across 24 DIMM slots, using RDIMM or LRDIMM modules.
How much internal storage can the HPE ML350 Gen10 LFF CTO Server accommodate?
It accommodates up to eight LFF drives (3.5″) or up to 24 SFF drives (2.5″) with an optional drive cage, delivering up to 192 TB raw capacity.
What RAID options are available on the HPE ML350 Gen10 LFF CTO Server?
It ships with HPE Smart Array S100i SATA RAID and offers optional Smart Array P408i-a with 12 Gb/s SAS support for advanced data protection.
How many PCIe expansion slots are available?
The server provides up to eight PCIe Gen3 slots, including two x4, four x8, and two x16 connectors for network and storage expansion.
What network connectivity options are supported?
It includes an embedded FlexibleLOM with four 1 GbE ports and supports optional 10 GbE, 25 GbE, or 100 GbE adapters for high-throughput networking.
Which management tools are integrated?
The system features HPE Integrated Lights-Out (iLO 5) for remote management, monitoring, firmware updates, and RESTful API automation.
What power supply configurations are available?
You can choose redundant hot-plug power supplies rated at 500 W, 800 W, or 1 600 W with up to 94% efficiency and HPE Power Discovery Services.
What are the dimensions and weight of the server?
The chassis measures 445 × 180 × 442 mm (17.5″×7.1″×17.4″) and weighs approximately 12.5 kg (27.6 lb) in base configuration.
Which operating systems does the HPE ML350 Gen10 support?
It supports Windows Server, Red Hat Enterprise Linux, SUSE Linux Enterprise Server, VMware ESXi, and other major enterprise OS platforms.
What are the primary use cases for this server?
This server is ideal for virtualization, database management, file and print services, remote office/branch office (ROBO), and SMB applications.
How energy-efficient is the HPE ML350 Gen10 LFF CTO Server?
It incorporates HPE Power Discovery Services, advanced power capping, and high-efficiency power supplies to minimize data center energy costs.
What reliability features does the server include?
It offers redundant hot-swap fans, power supplies, optional hot-plug drives, plus HPE’s silicon root of trust for increased uptime and data security.
What warranty and support options are available?
The server comes with a standard 3-year parts, labor, and on-site warranty, with optional HPE Foundation Care and Proactive Care service upgrades.