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826566-B21
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- HPE ProLiant DL380 Gen10 5118 2.3GHz 12-core 2P 64GB-R P408i-a 8SFF 2x800W PS Performance Serve
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826566-B21
HPE ProLiant DL380 Gen10 5118 2.3GHz 12-core 2P 64...
$11,521.66
$7,258.65
44 in Global Warehouse
$7,258.65
37% off
TRUSTED, TRIED, PROVEN
826566-B21 Overview
826566-B21 is a high-performance rackmount server designed for data centers and enterprise environments. It supports Intel Xeon Scalable processors on an LGA 4189 socket with 2P scalability, paired with ECC DDR4 memory that scales up to 512 GB via 16 DIMM slots. The system features 4 PCIe 4.0 expansion slots, 8 drive bays configured for 3.5-inch storage, and RAID support including RAID 0, 1, 5, and 10. Integrated dual 1GbE network interfaces ensure reliable connectivity, while redundant 750W power supplies, active cooling, and iDRAC remote management provide high availability and secure monitoring.
This server is optimized for virtualization, file serving, and application hosting in demanding data center settings. It runs officially supported operating systems such as Windows Server, VMware ESXi, Ubuntu, RHEL, and CentOS, making it an ideal choice for cloud hosting and enterprise applications. The 826566-B21 is built to deliver consistent performance, scalability, and reliability in mission-critical environments.
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826566-B21 Specifications
| Product Type | Server |
| Form Factor | Rackmount |
| Rack Units | 2U |
| Processor Brand | Intel |
| Processor Series | Intel Xeon Scalable |
| Processor Generation | Xeon 4th Gen |
| Use Case | Virtualization |
| CPU Socket | LGA 4189 |
| Scalability | 2P |
| Max Cores Per CPU | 32 |
| Max Threads Per CPU | 64 |
| RAM Type | ECC DDR4 |
| RAM Slots | 16 |
| Max RAM Capacity | 512 GB |
| Storage Type | Hybrid |
| Storage Bays | 8 |
| Drive Bay Size | 3.5-inch |
| Hot-Swap Support | Yes |
| RAID Support | RAID 0 / RAID 1 / RAID 5 / RAID 10 |
| PCIe Slots | 4 |
| PCIe Version | PCIe 4.0 |
| Network Interface | 1GbE |
| LAN Ports | 2 |
| Remote Management | iDRAC |
| Power Supply | Redundant |
| Power Supply Wattage | 750W |
| Cooling | Active |
| Operating System | Windows Server / VMware ESXi / Ubuntu / RHEL / CentOS |
| Virtualization Ready | Yes |
| GPU Support | Yes |
| Rail Kit Included | N/A |
| Product Name | 826566-B21 |
| Height | 3.5 inches |
| Width | 17.2 inches |
| Depth | 28 inches |
| Weight | 45 lbs |
826566-B21 Use Case
Virtualization Host for Private Cloud Consolidation with HPE ProLiant DL380 Gen10 5118
In a mid-sized financial services environment, IT teams deploy the 826566-B21 HPE ProLiant DL380 Gen10 (5118 2.3 GHz 12-core 2P, 64 GB-R, P408i-a, 8 SFF, 2×800 W) to consolidate 50+ VMware vSphere VMs on a single cluster node. The result is a 30% reduction in TCO and a 40% increase in VM density, delivering streamlined resource management and accelerated provisioning without expanding rack space.
High-Performance SQL Database Server for E-Commerce Peak Traffic
An online retailer leverages the HPE ProLiant DL380 Gen10 5118 dual-processor server with 64 GB RAM and P408i-a RAID to power its Microsoft SQL transaction engine during flash-sale events. Sub-200 ms query latency and sustained 99.99% uptime ensure frictionless checkout experiences, while scalable IOPS handle 2× spike in concurrent users without performance degradation.
Bioinformatics Pipeline Acceleration for Genomic Research
A genomics research institute uses the 826566-B21 HPE ProLiant DL380 Gen10 (5118 12-core CPUs, 64 GB memory, 8 SFF bays) to execute high-throughput DNA sequencing workflows and variant-calling pipelines. Local NVMe caching and 24-core parallelism cut analysis runtimes by 50%, enabling faster insights and more iterative experiment cycles in precision medicine studies.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table
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| Cooling | Active | Active | Active | Active | Active |
| CPU Socket | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 |
| Depth | 28 inches | 28 inches | 29 inches | 28.0 inches | 28 inches |
| Drive Bay Size | 3.5-inch | 3.5-inch | Mixed | Mixed | 3.5-inch |
| Form Factor | Rackmount | Rackmount | Rackmount | Rackmount | Rackmount |
| GPU Support | Yes | Yes | Yes | Yes | Yes |
| Height | 3.5 inches | 3.5 inches | 7 inches | 3.5 inches | 3.5 inches |
| Hot-Swap Support | Yes | Yes | Yes | Yes | Yes |
| LAN Ports | 2 | 4 | 4 | 2 | 4 |
| Max Cores per CPU | 32 | 32 | 64 | 32 | 32 |
| Max RAM Capacity | 512 GB | 1 TB | 2 TB | 2 TB | 1 TB |
| Max Threads per CPU | 64 | 64 | 128 | 64 | 64 |
| Network Interface | 1GbE | 1GbE | 10GbE | 10GbE | 10GbE |
| Operating System | Windows Server / VMware ESXi / Ubuntu / RHEL / CentOS | Windows Server / VMware ESXi / Ubuntu | VMware ESXi | Windows Server | VMware ESXi |
| PCIe Slots | 4 | 4 | 4 | 6 | 4 |
| PCIe Version | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 |
| Power Supply | Redundant | Redundant | Redundant | Redundant | Redundant |
| Power Supply Wattage | 750W | 800W | 750W | 800W | 1200W |
| Processor Brand | Intel | Intel | Intel | Intel | Intel |
| Processor Generation | Xeon 4th Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 4th Gen | Xeon 3rd Gen |
| Processor Series | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable |
| Product Name | 826566-B21 | 875763-S01 Enterprise Rack Server | 850520-S01 Enterprise Rackmount Server | 766342-B21 Enterprise Rackmount Server | Q9A03A Series Enterprise Rackmount Server |
| Product Type | Server | Server | Server | Server | Server |
| Rack Units | 2U | 2U | 2U | 2U | 2U |
| RAID Support | RAID 0 / RAID 1 / RAID 5 / RAID 10 | RAID 1 / RAID 5 / RAID 10 | RAID 10 | RAID 10 | RAID 10 |
| Rail Kit Included | N/A | N/A | N/A | Yes | Yes |
| RAM Slots | 16 | 16 | 16 | 16 | 16 |
| RAM Type | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 |
| Remote Management | iDRAC | iDRAC | iDRAC | iDRAC | iDRAC |
| Scalability | 2P | 2P | 2P | 2P | 2P |
| Storage Bays | 8 | 8 | 8 | 12 | 8 |
| Storage Type | Hybrid | Hybrid | SATA SSD | Hybrid | SATA SSD |
| Use Case | Virtualization | Virtualization / File Server / Application Server | Virtualization | Virtualization | Virtualization |
| Virtualization Ready | Yes | Yes | Yes | Yes | Yes |
| Weight | 45 lbs | 45 lbs | 50 lbs | 50 lbs | 60 lbs |
| Width | 17.2 inches | 17.2 inches | 19 inches | 17.5 inches | 17 inches |
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Questions & Answers
Q
What CPUs come with the HPE ProLiant DL380 Gen10 826566-B21?
A
The 826566-B21 ships with dual Intel Xeon Silver 5118 processors (2.3 GHz, 12 cores each) supporting up to 24 threads per CPU for balanced performance and efficiency.
Q
How much memory is preinstalled in this DL380 Gen10 server?
A
It includes 64 GB of DDR4 RDIMM memory (4×16 GB) running at 2666 MT/s, expandable up to 3 TB across 24 DIMM slots for demanding workloads.
Q
What storage options are available in the 8-SFF chassis?
A
The 8 small-form-factor hot-plug drive bays support SAS, SATA, and NVMe SSD/HDD combinations, delivering flexible tiered storage with up to 96 TB raw capacity.
Q
Which RAID levels does the Smart Array P408i-a controller support?
A
The embedded HPE Smart Array P408i-a supports RAID 0, 1, 5, 6, 10, 50, and 60 with optional flash-backed write cache for data protection and performance.
Q
What power supplies are included and can they be upgraded?
A
Two hot-plug 800 W redundant power supplies are standard. Optional 1600 W or 1200 W Flex Slot PSUs are available for improved efficiency and higher-density configurations.
Q
How does HPE iLO enhance server management?
A
HPE iLO (Integrated Lights-Out) provides remote console access, firmware updates, health monitoring, and scripting APIs for automated out-of-band management.
Q
What network connectivity is integrated on this server?
A
Dual 1 Gb Ethernet ports are built in, with optional FlexibleLOM or PCIe network adapters supporting 10/25/40/100 GbE for high-throughput environments.
Q
Which operating systems are certified for the DL380 Gen10?
A
It is certified for Microsoft Windows Server, VMware ESXi, Red Hat Enterprise Linux, SUSE Linux Enterprise Server, and other HPE-approved OSes.
Q
Can I add GPU or FPGA accelerators to the DL380 Gen10?
A
Yes. It supports up to three single-width or two double-width GPUs/FPGA cards via available PCIe Gen3 slots, ideal for AI, ML, and virtualization.
Q
What security features protect my data on this server?
A
Built-in HPE Silicon Root of Trust, Secure Boot, Runtime Firmware Verification, and TPM 2.0 ensure firmware integrity and data confidentiality.
Q
How scalable is the memory and storage expansion?
A
With 24 DIMM slots and up to 8 SFF bays, you can scale memory to 3 TB and add external storage via HPE Smart Array controllers or M.2 boot kits.
Q
Is this server suitable for virtualization workloads?
A
Absolutely. Dual 12-core CPUs, 64 GB memory, flexible networking, and RAID support make it ideal for VMware, Hyper-V, and containerized environments.
Q
What warranty and support options are available?
A
Standard is a 3-year HPE Foundation Care warranty with next-business-day onsite support. Upgrades to 24/7 coverage and Proactive Care are available.
Q
How energy efficient is the DL380 Gen10?
A
It features HPE’s power-efficient components and Intelligent Power Discovery, achieving ENERGY STAR certification and reducing cooling costs.
Q
What distinguishes the Performance Server variant?
A
The Performance Server SKU includes higher core-count CPUs, faster memory speeds, and advanced storage/RAID options optimized for compute-intensive applications.
