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826566-B21

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HPE ProLiant DL380 Gen10 5118 2.3GHz 12-core 2P 64GB-R P408i-a 8SFF 2x800W PS Performance Serve
Rating:
4.6(5)

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826566-b21 hpe proliant dl380 gen10 5118 2.3ghz 12-core 2p 64gb-r p408i-a 8sff 2x800w ps performance serve

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826566-B21

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HPE ProLiant DL380 Gen10 5118 2.3GHz 12-core 2P 64GB-R P408i...

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826566-B21 Overview

826566-B21 is a high-performance rackmount server designed for data centers and enterprise environments. It supports Intel Xeon Scalable processors on an LGA 4189 socket with 2P scalability, paired with ECC DDR4 memory that scales up to 512 GB via 16 DIMM slots. The system features 4 PCIe 4.0 expansion slots, 8 drive bays configured for 3.5-inch storage, and RAID support including RAID 0, 1, 5, and 10. Integrated dual 1GbE network interfaces ensure reliable connectivity, while redundant 750W power supplies, active cooling, and iDRAC remote management provide high availability and secure monitoring.

This server is optimized for virtualization, file serving, and application hosting in demanding data center settings. It runs officially supported operating systems such as Windows Server, VMware ESXi, Ubuntu, RHEL, and CentOS, making it an ideal choice for cloud hosting and enterprise applications. The 826566-B21 is built to deliver consistent performance, scalability, and reliability in mission-critical environments.

826566-B21 price is $7,258.65, a 37% saving from the Hpe list price of $11,521.66. 826566-B21 is in stock and available for next-day dispatch. (terms applied)

Request bulk order quote for 826566-B21 for additional pricing. Browse the full Hpe Proliant Dl380 Gen10 Servers series or explore all Hpe products.

826566-B21 Specifications

Product Type
Server
Brand
Hpe
Form Factor
Rackmount
Rack Units
2U
Processor Brand
Intel
Processor Series
Intel Xeon Scalable
Processor Generation
Xeon 4th Gen
Use Case
Virtualization
CPU Socket
LGA 4189
Scalability
2P
Max Cores per CPU
32
Max Threads per CPU
64
RAM Type
ECC DDR4
RAM Slots
16
Max RAM Capacity
512 GB
Storage Type
Hybrid
Storage Bays
8
Drive Bay Size
3.5-inch
Hot-Swap Support
Yes
RAID Support
RAID 0 / RAID 1 / RAID 5 / RAID 10
PCIe Slots
4
PCIe Version
PCIe 4.0
Network Interface
1GbE
LAN Ports
2
Remote Management
iDRAC
Power Supply
Redundant
Power Supply Wattage
750W
Cooling
Active
Operating System
Windows Server / VMware ESXi / Ubuntu / RHEL / CentOS
Virtualization Ready
Yes
GPU Support
Yes
Product Name
826566-B21
Height
3.5 inches
Width
17.2 inches
Depth
28 inches
Weight
45 lbs

826566-B21 Use Case

Virtualization Host for Private Cloud Consolidation with HPE ProLiant DL380 Gen10 5118

In a mid-sized financial services environment, IT teams deploy the 826566-B21 HPE ProLiant DL380 Gen10 (5118 2.3 GHz 12-core 2P, 64 GB-R, P408i-a, 8 SFF, 2×800 W) to consolidate 50+ VMware vSphere VMs on a single cluster node. The result is a 30% reduction in TCO and a 40% increase in VM density, delivering streamlined resource management and accelerated provisioning without expanding rack space.

High-Performance SQL Database Server for E-Commerce Peak Traffic

An online retailer leverages the HPE ProLiant DL380 Gen10 5118 dual-processor server with 64 GB RAM and P408i-a RAID to power its Microsoft SQL transaction engine during flash-sale events. Sub-200 ms query latency and sustained 99.99% uptime ensure frictionless checkout experiences, while scalable IOPS handle 2× spike in concurrent users without performance degradation.

Bioinformatics Pipeline Acceleration for Genomic Research

A genomics research institute uses the 826566-B21 HPE ProLiant DL380 Gen10 (5118 12-core CPUs, 64 GB memory, 8 SFF bays) to execute high-throughput DNA sequencing workflows and variant-calling pipelines. Local NVMe caching and 24-core parallelism cut analysis runtimes by 50%, enabling faster insights and more iterative experiment cycles in precision medicine studies.

Product Comparison Table

HPE ProLiant DL380 Gen10 5118 2.3GHz 12-core 2P 64GB-R P408i-a 8SFF 2x800W PS Performance Serve826566-B21HPE ProLiant DL380 Gen10 6126 2.6GHz 12-core 1P 32GB-R P408i-a 8SFF 2x500W PS Server/S-Buy875763-S01HPE ProLiant DL380 Gen9 E5-2667v4 32GB-R P440ar 8SFF 2x500W PS Server850520-S01HPE ProLiant DL380 Gen9 E5-2609v3 8GB-R B140i 4LFF SATA 500W PS Entry Server766342-B21HPE ProLiant DL388 Gen10 4110 2.1GHz 8C 85W 1P 16G-2R P408i-a 8SFF 1x500W Base CN ServerQ9A03A
CPU SocketLGA 4189LGA 4189LGA 4189LGA 4189LGA 4189
CoolingActiveActiveActiveActiveActive
Depth28 inches28 inches29 inches28.0 inches28 inches
Drive Bay Size3.5-inch3.5-inchMixedMixed3.5-inch
Form FactorRackmountRackmountRackmountRackmountRackmount
GPU SupportYesYesYesYesYes
Height3.5 inches3.5 inches7 inches3.5 inches3.5 inches
Hot-Swap SupportYesYesYesYesYes
LAN Ports24424
Max Cores per CPU3232643232
Max RAM Capacity512 GB1 TB2 TB2 TB1 TB
Max Threads per CPU64641286464
Network Interface1GbE1GbE10GbE10GbE10GbE
Operating SystemWindows Server / VMware ESXi / Ubuntu / RHEL / CentOSWindows Server / VMware ESXi / UbuntuVMware ESXiWindows ServerVMware ESXi
PCIe Slots44464
PCIe VersionPCIe 4.0PCIe 4.0PCIe 4.0PCIe 4.0PCIe 4.0
Power SupplyRedundantRedundantRedundantRedundantRedundant
Power Supply Wattage750W800W750W800W1200W
Processor BrandIntelIntelIntelIntelIntel
Processor GenerationXeon 4th GenXeon 3rd GenXeon 3rd GenXeon 4th GenXeon 3rd Gen
Processor SeriesIntel Xeon ScalableIntel Xeon ScalableIntel Xeon ScalableIntel Xeon ScalableIntel Xeon Scalable
Product Name826566-B21875763-S01 Enterprise Rack Server850520-S01 Enterprise Rackmount Server766342-B21 Enterprise Rackmount ServerQ9A03A Series Enterprise Rackmount Server
Product TypeServerServerServerServerServer
RAID SupportRAID 0 / RAID 1 / RAID 5 / RAID 10RAID 1 / RAID 5 / RAID 10RAID 10RAID 10RAID 10
RAM Slots1616161616
RAM TypeECC DDR4ECC DDR4ECC DDR4ECC DDR4ECC DDR4
Rack Units2U2U2U2U2U
Remote ManagementiDRACiDRACiDRACiDRACiDRAC
Scalability2P2P2P2P2P
Storage Bays888128
Storage TypeHybridHybridSATA SSDHybridSATA SSD
Use CaseVirtualizationVirtualization / File Server / Application ServerVirtualizationVirtualizationVirtualization
Virtualization ReadyYesYesYesYesYes
Weight45 lbs45 lbs50 lbs50 lbs60 lbs
Width17.2 inches17.2 inches19 inches17.5 inches17 inches

Compliance & Coverage

ISO 27001
ISO 45001
RoHS
REACH
FCC
CE
UKCA
VCCI
ISO 9001
ISO 14001

100% Genuine Product Guarantee

Every unit is authentic, sourced through trusted and authorised channels, and serial-verified on request. Genuine networking and IT hardware, guaranteed, or your money back.

Up to 3-Year Warranty Coverage

New products are backed by up to 3 years of extended warranty, and certified refurbished units by up to 3 months, for dependable protection on every order. Coverage is clear, honoured in full, and confirmed on each product page.

Hassle-Free RMA & Returns

If a unit ever falls short, our streamlined RMA process gets a replacement to you fast, with advance replacement available to keep your network running. No jargon, no runaround.

Rigorously Tested & Quality Assured

Every device is inspected, bench-tested, and firmware-verified, with configurations wiped before dispatch. Additional testing can be arranged to confirm full working condition on request.

Expert Technical Support

Our specialists assist with compatibility, configuration, licensing, and installation, before and after you buy. Real hardware expertise, whenever you need it.

Fast Global Delivery

dispatched quickly and shipped worldwide from regional hubs, fully tracked and insured.

Reviews & Ratings

E
Evan Thornton
5

Performance configuration delivers strong dual socket output.

K
Kamran Ashfaq
5

Excellent stability for virtualization clusters.

G
Giuseppe Conti
4

Consistent throughput under load.

H
Henry Patterson
5

Enterprise ready compute performance.

S
Salman Raza
4

Meets high performance expectations.

Questions & Answers

What CPUs come with the HPE ProLiant DL380 Gen10 826566-B21?

The 826566-B21 ships with dual Intel Xeon Silver 5118 processors (2.3 GHz, 12 cores each) supporting up to 24 threads per CPU for balanced performance and efficiency.

How much memory is preinstalled in this DL380 Gen10 server?

It includes 64 GB of DDR4 RDIMM memory (4×16 GB) running at 2666 MT/s, expandable up to 3 TB across 24 DIMM slots for demanding workloads.

What storage options are available in the 8-SFF chassis?

The 8 small-form-factor hot-plug drive bays support SAS, SATA, and NVMe SSD/HDD combinations, delivering flexible tiered storage with up to 96 TB raw capacity.

Which RAID levels does the Smart Array P408i-a controller support?

The embedded HPE Smart Array P408i-a supports RAID 0, 1, 5, 6, 10, 50, and 60 with optional flash-backed write cache for data protection and performance.

What power supplies are included and can they be upgraded?

Two hot-plug 800 W redundant power supplies are standard. Optional 1600 W or 1200 W Flex Slot PSUs are available for improved efficiency and higher-density configurations.

How does HPE iLO enhance server management?

HPE iLO (Integrated Lights-Out) provides remote console access, firmware updates, health monitoring, and scripting APIs for automated out-of-band management.

What network connectivity is integrated on this server?

Dual 1 Gb Ethernet ports are built in, with optional FlexibleLOM or PCIe network adapters supporting 10/25/40/100 GbE for high-throughput environments.

Which operating systems are certified for the DL380 Gen10?

It is certified for Microsoft Windows Server, VMware ESXi, Red Hat Enterprise Linux, SUSE Linux Enterprise Server, and other HPE-approved OSes.

Can I add GPU or FPGA accelerators to the DL380 Gen10?

Yes. It supports up to three single-width or two double-width GPUs/FPGA cards via available PCIe Gen3 slots, ideal for AI, ML, and virtualization.

What security features protect my data on this server?

Built-in HPE Silicon Root of Trust, Secure Boot, Runtime Firmware Verification, and TPM 2.0 ensure firmware integrity and data confidentiality.

How scalable is the memory and storage expansion?

With 24 DIMM slots and up to 8 SFF bays, you can scale memory to 3 TB and add external storage via HPE Smart Array controllers or M.2 boot kits.

Is this server suitable for virtualization workloads?

Absolutely. Dual 12-core CPUs, 64 GB memory, flexible networking, and RAID support make it ideal for VMware, Hyper-V, and containerized environments.

What warranty and support options are available?

Standard is a 3-year HPE Foundation Care warranty with next-business-day onsite support. Upgrades to 24/7 coverage and Proactive Care are available.

How energy efficient is the DL380 Gen10?

It features HPE’s power-efficient components and Intelligent Power Discovery, achieving ENERGY STAR certification and reducing cooling costs.

What distinguishes the Performance Server variant?

The Performance Server SKU includes higher core-count CPUs, faster memory speeds, and advanced storage/RAID options optimized for compute-intensive applications.