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CTO flexibility allowed us to tailor the rack server exactly to our workload requirements.
877627-B21
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HPE ML350 Gen10 SFF Rack CTO Server
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877627-B21
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- HPE ML350 Gen10 SFF Rack CTO Server
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877627-B21 Overview
877627-B21 is a high-performance rackmount server designed for data center and virtualization applications. It supports Intel Xeon Scalable processors on the LGA 4189 socket with 2P scalability, paired with ECC DDR4 memory supporting up to 2 TB capacity. The server offers multiple expansion slots and 8 drive bays configured for 2.5-inch storage devices with RAID 10 support to ensure optimal data integrity and speed. It also features 10GbE network interfaces and redundant power supplies rated at 800W, alongside active cooling and integrated iDRAC remote management.
This server is optimized for demanding use cases such as virtualization, file serving, and application hosting. It comes pre-configured with VMware ESXi support and is ideal for deployment in data centers where reliability, scalability, and performance are essential. The design ensures a compact rackmount form factor while delivering robust expansion options to meet evolving business needs.
877627-B21 price is is available on request. Get immediate quote.
Request bulk order quote for 877627-B21 for additional pricing. Browse the full Hpe Proliant Ml350 Gen9/10 Servers series or explore all Hpe products.
877627-B21 Specifications
- Width
- 17.5 inches
- Depth
- 28 inches
- Height
- 3.5 inches
- Weight
- 50 lbs
- Form Factor
- Rackmount
- PCIe Version
- PCIe 4.0
- RAID Support
- RAID 10
- CPU Socket
- LGA 4189
- Product Type
- Server
- Rack Units
- 2U
- Processor Brand
- Intel
- Processor Series
- Intel Xeon Scalable
- Processor Generation
- Xeon 4th Gen
- Scalability
- 2P
- Max Cores per CPU
- 32
- Max Threads per CPU
- 64
- RAM Type
- ECC DDR4
- RAM Slots
- 16
- Max RAM Capacity
- 2 TB
- Storage Bays
- 8
- Hot-Swap Support
- Yes
- PCIe Slots
- 4
- Network Interface
- 10GbE
- LAN Ports
- 2
- Remote Management
- iDRAC
- Power Supply
- Redundant
- Cooling
- Active
- Virtualization Ready
- Yes
- GPU Support
- Yes
- Drive Bay Size
- 2.5-inch
- Power Supply Wattage
- 800W
- Operating System
- VMware ESXi
- Rail Kit Included
- No
- Storage Type
- SATA SSD
- Use Case
- Virtualization / File Server / Application Server
- Product Name
- 877627-B21 High Performance Rack Server
877627-B21 Use Case
Enterprise Virtualization Consolidation with HPE ML350 Gen10
In a mid-sized enterprise data center, IT teams deploy the 877627-B21 HPE ML350 Gen10 SFF Rack CTO Server to consolidate 150+ virtual machines onto a single chassis. Leveraging dual Intel Xeon Scalable processors, 512 GB of DDR4 memory and HPE iLO 5 for remote management, the server reduces total cost of ownership by 30% and accelerates VM provisioning by 40%. Outcome: streamlined operations, high availability and 25% improved energy efficiency.
Edge AI Inference and Real-Time Analytics in Manufacturing
A manufacturing firm installs the 877627-B21 HPE ML350 Gen10 SFF Rack CTO Server at its production lines to process high-volume sensor data at the edge. With a compact small-form-factor design, up to four NVMe drives and optional GPU support for AI inference, the server delivers sub-millisecond latency analytics on the shop floor. Outcome: enhanced quality control, 20% reduced downtime and real-time decision-making capabilities.
High-Performance Transactional Database & Application Hosting
A financial services provider adopts the 877627-B21 HPE ML350 Gen10 SFF Rack CTO Server as its primary SQL Server and application platform. Equipped with HPE Smart Array controllers, redundant hot-swap power supplies and up to 30 TB of high-speed storage, it sustains 10,000+ transactions per second with 99.999% uptime. Outcome: consistent transaction performance, superior customer experience and built-in compliance security.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table 
| 877627-B21 |  P11051-AA1 |  835262-001 |  765821-001 |  P04674-S01 | |
|---|---|---|---|---|---|
| CPU Socket | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 |
| Cooling | Active | Active | Active | Active | Active |
| Depth | 28 inches | 28 inches | 28 inches | 28 inches | 28 inches |
| Drive Bay Size | 2.5-inch | 2.5-inch | Mixed | 3.5-inch | 3.5-inch |
| Form Factor | Rackmount | Rackmount | Rackmount | Rackmount | Rackmount |
| GPU Support | Yes | Yes | Yes | Yes | Yes |
| Height | 3.5 inches | 3.5 inches | 3.5 inches | 3.5 inches | 1.75 inches |
| Hot-Swap Support | Yes | Yes | Yes | Yes | Yes |
| LAN Ports | 2 | 2 | 4 | 2 | 2 |
| Max Cores per CPU | 32 | 32 | 32 | 32 | 32 |
| Max RAM Capacity | 2 TB | 1 TB | 1 TB | 1 TB | 512 GB |
| Max Threads per CPU | 64 | 64 | 64 | 64 | 64 |
| Network Interface | 10GbE | 10GbE | 10GbE | 10GbE | 1GbE |
| Operating System | VMware ESXi | VMware ESXi | VMware ESXi | Windows Server | Windows Server, VMware ESXi, Ubuntu |
| PCIe Slots | 4 | 4 | 6 | 4 | 4 |
| PCIe Version | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 |
| Power Supply | Redundant | Redundant | Redundant | Redundant | Redundant |
| Power Supply Wattage | 800W | 1000W | 750W | 750W | 750W |
| Processor Brand | Intel | Intel | Intel | Intel | Intel |
| Processor Generation | Xeon 4th Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 4th Gen |
| Processor Series | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable |
| Product Name | 877627-B21 High Performance Rack Server | P11051-AA1 High Performance Rack Server | 835262-001 High Performance Server | 765821-001 Enterprise Rackmount Server | P04674-S01 High Performance Rack Server |
| Product Type | Server | Server | Server | Server | Server |
| RAID Support | RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 10 | RAID 10 | |
| RAM Slots | 16 | 16 | 16 | 16 | 16 |
| RAM Type | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 |
| Rack Units | 2U | 2U | 2U | 2U | 1U |
| Rail Kit Included | No | Yes | Yes | N/A | No |
| Remote Management | iDRAC | iDRAC | iDRAC | iDRAC | iDRAC |
| Scalability | 2P | 2P | 2P | 2P | 2P |
| Storage Bays | 8 | 8 | 12 | 4 | 8 |
| Storage Type | SATA SSD | SATA SSD | Hybrid | SATA HDD | SATA SSD |
| Use Case | Virtualization / File Server / Application Server | Virtualization | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server | Virtualization |
| Virtualization Ready | Yes | Yes | Yes | Yes | Yes |
| Weight | 50 lbs | 45 lbs | 60 lbs | 65 lbs | 45 lbs |
| Width | 17.5 inches | 17 inches | 17.5 inches | 17 inches | 19 inches |
Reviews & Ratings
A
Areeb Hassan
5
Stable base platform for custom enterprise builds.
J
Julien Moreau
4
Good airflow and dependable performance once configured.
M
Marko Petrovic
5
Works well in dense rack environments with predictable behavior.
S
Shayan Ali
4
Reliable foundation for scalable infrastructure deployments.
Questions & Answers
What are the key specifications of the HPE ML350 Gen10 SFF Rack CTO Server (SKU: 877627-B21)?
The HPE ML350 Gen10 SFF Rack CTO Server features dual Intel Xeon Scalable processors, 24 DDR4 DIMM slots (up to 3 TB), eight small form factor drive bays, six PCIe Gen3 expansion slots, integrated HPE iLO 5 management and redundant hot-swappable power supplies.
Which Intel processors are supported in the HPE ML350 Gen10 SFF Rack CTO Server?
This server supports Intel Xeon Scalable family CPUs—from Bronze to Platinum—with up to 28 cores per socket, delivering scalable performance for virtualization, databases and analytics workloads.
What is the maximum memory capacity and configuration for the HPE ML350 Gen10 SFF?
The system supports up to 3 TB of DDR4 ECC memory across 24 DIMM slots using HPE LRDIMMs at speeds up to 2666 MT/s, optimizing performance for memory-intensive applications.
How much storage can the HPE ML350 Gen10 SFF Rack CTO Server hold?
It provides eight front-accessible SFF drive bays supporting SAS, SATA or NVMe SSD/HDD modules and up to two rear SFF bays, enabling flexible high-density storage configurations.
What expansion capabilities does the HPE ML350 Gen10 offer?
The server includes six PCIe Gen3 slots—three x16 and three x8—plus an optional FlexibleLOM slot for additional networking or storage controllers.
What networking options are available on the HPE ML350 Gen10 SFF Rack CTO Server?
Standard integrated options include two 1GbE ports, with optional FlexibleLOM or PCIe adapters for 10/25/40/100 GbE connectivity to meet diverse networking demands.
How does HPE iLO 5 enhance management of the ML350 Gen10 SFF Server?
HPE iLO 5 offers agentless remote monitoring, automated firmware updates, one-click secure recovery and advanced scripting for streamlined deployment and maintenance.
What security features protect the HPE ML350 Gen10 SFF Rack CTO Server?
Security includes HPE Silicon Root of Trust, Secure Boot, Trusted Platform Module 2.0 and runtime firmware validation, ensuring end-to-end platform integrity.
Can the HPE ML350 Gen10 SFF Server convert from tower to rack mounting?
Yes, this CTO model is available in a convertible chassis that transitions from a tower to a 5U rack configuration for flexible data-center deployment.
Which operating systems are certified on the HPE ML350 Gen10 SFF Rack CTO Server?
Certified OS support includes Microsoft Windows Server, Red Hat Enterprise Linux, SUSE Linux Enterprise Server, VMware vSphere, Citrix XenServer and other major platforms.
What typical workloads are ideal for the HPE ML350 Gen10 SFF Server?
This server excels in virtualization, database, analytics, high-performance computing and remote office/branch office deployments requiring balanced compute, storage and scalability.
What warranty and support options are available for the HPE ML350 Gen10?
Standard warranty is three years parts, labor and next-business-day onsite support; optional HPE Care Pack services extend coverage and upgrade response times.
How does the HPE ML350 Gen10 ensure energy efficiency?
With 80 PLUS Platinum or Titanium power supplies, HPE Power Advisor guidance and Intelligent System Tuning, this server minimizes energy usage while maximizing performance.
Is the HPE ML350 Gen10 SFF Rack CTO Server suitable for virtualization?
Absolutely—it supports large memory footprints, multi-core processors and high-speed networking to host multiple virtual machines with consistent performance.
How scalable is the HPE ML350 Gen10 for future growth?
Its modular design allows easy addition of CPUs, memory, storage and networking cards, ensuring seamless expansion as business demands evolve.