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P06421-B21
HPE ProLiant DL380 Gen10 4114 2.2GHz 10-core 1P 32GB-R P408i...
Federal agencies and Fortune 500 operations source through ORM Systems.
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Pay by PayPal or Revolut with full chargeback rights. Order on PO terms, Net-30 for government.
Every registration we claim is public record — check our federal contractor status yourself before you spend a dollar.
Ten years serving buyers who audit their vendors. From federal agencies to 20,000+ enterprise clients worldwide.
P06421-B21 is a rackmount server that supports Intel Xeon Scalable 3rd Gen processors with an LGA 4189 socket, offering 2P CPU scalability. It features ECC DDR5 memory across 16 DIMM slots with a maximum capacity of 2 TB, 6 PCIe 4.0 expansion slots, and 8 available 3.5-inch storage bays supporting RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10 configurations.
P06421-B21 includes dual 10GbE network interfaces, redundant 1000W power supplies, active cooling, and iDRAC remote management. It officially supports operating systems such as Windows Server, VMware ESXi, and Ubuntu, making it ideal for data center, virtualization, file server, and application server use cases.
P06421-B21 price is is available on request. Get immediate quote.
Request bulk order quote for P06421-B21 for additional pricing. Browse the full Hpe Proliant Dl380 Gen10 Servers series or explore all Hpe products.
A mid-size data center migrates from multiple legacy servers to a single P06421-B21 HPE ProLiant DL380 Gen10 (Intel® Xeon® Silver 4114 2.2 GHz 10-core, 32 GB RDIMM, P408i-a RAID, 8 SFF bays, 800 W PSU) running VMware vSphere. Key benefits: • 40% reduction in rack space and power consumption • 35% faster VM provisioning and patching • Centralized management via HPE OneView Outcome: Lower total cost of ownership (TCO) and enhanced operational agility for business-critical workloads.
A financial services firm deploys the P06421-B21 HPE ProLiant DL380 Gen10 for its SQL Server OLTP environment. With Intel® Xeon® Silver 4114, 32 GB memory, P408i-a RAID controller and 8 SFF SSDs, the server delivers high IOPS and sub-millisecond latency under peak load. Key benefits: • 50% faster query response times • 99.99% uptime with redundant power and HPE iLO monitoring • Seamless scalability with additional DIMMs and drives Outcome: Improved customer satisfaction and compliance through reliable, low-latency transaction processing.
A retail analytics team leverages the P06421-B21 HPE ProLiant DL380 Gen10 (Intel® Xeon® Silver 4114, 32 GB RDIMM, P408i-a, 8 SFF, 800 W) integrated with HPE InfoSight and containerized AI frameworks. The server processes large datasets and delivers real-time insights. Key benefits: • 3× faster AI model inference times • Predictive maintenance reducing downtime by 30% • Native integration with cloud AI services Outcome: Accelerated data-driven decision-making and increased revenue through personalized customer experiences.
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| P06421-B21 |  P05524-B21 |  752687-B21 |  868705-B21 |  Q9A06A | |
|---|---|---|---|---|---|
| CPU Socket | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 |
| Cooling | Active | Active | Active | Active | Active |
| Depth | 28 inches | 28.7 inches | 27 inches | 28.0 inches | 28.0 inches |
| Drive Bay Size | 3.5-inch | 2.5-inch | 3.5-inch | 3.5-inch | 3.5-inch |
| Form Factor | Rackmount | Rackmount / Tower | Rackmount | Rackmount | Rackmount |
| GPU Support | Yes | Yes | Yes | Yes | Yes |
| Height | 3.5 inches | 6.88 inches | 3.5 inches | 3.5 inches | 3.5 inches |
| Hot-Swap Support | Yes | Yes | Yes | Yes | Yes |
| LAN Ports | 2 | 4 | 4 | 2 | 2 |
| Max Cores per CPU | 32 | 32 | 32 | 32 | 32 |
| Max RAM Capacity | 2 TB | 2 TB | 1 TB | 2 TB | 1 TB |
| Max Threads per CPU | 64 | 64 | 64 | 64 | 64 |
| Network Interface | 10GbE | 10GbE | 10GbE | 10GbE | 10GbE |
| Operating System | Windows Server / VMware ESXi / Ubuntu | Windows Server / VMware ESXi / Ubuntu | Windows Server | Windows Server / VMware ESXi / Ubuntu | Windows Server / VMware ESXi / Ubuntu / RHEL |
| PCIe Slots | 6 | 6 | 4 | 4 | 4 |
| PCIe Version | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 |
| Power Supply | Redundant | Redundant | Redundant | Redundant | Redundant |
| Power Supply Wattage | 1000W | 800W | 1200W | 800W | 750W |
| Processor Brand | Intel | Intel | Intel | Intel | Intel |
| Processor Generation | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 4th Gen |
| Processor Series | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable |
| Product Name | P06421-B21 | P05524-B21 | 752687-B21 Enterprise Rack Server | 868705-B21 Server System | Q9A06A Enterprise Server |
| Product Type | Server | Server | Server | Server | Server |
| RAID Support | RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 10 | RAID 10 | RAID 0 / RAID 1 / RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10 |
| RAM Slots | 16 | 16 | 8 | 16 | 16 |
| RAM Type | ECC DDR5 | ECC DDR4 | ECC DDR4 | ECC DDR5 | ECC DDR4 |
| Rack Units | 2U | 2U | 2U | 2U | 2U |
| Remote Management | iDRAC | iDRAC | iDRAC | iDRAC | iDRAC |
| Scalability | 2P | 2P | 2P | 2P | 2P |
| Storage Bays | 8 | 8 | 8 | 8 | 4 |
| Storage Type | SATA SSD | SAS HDD | SATA SSD | SATA SSD | Hybrid |
| Use Case | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server | Virtualization | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server |
| Virtualization Ready | Yes | Yes | Yes | Yes | Yes |
| Weight | 45 lbs | 55 lbs | 60 lbs | 50 lbs | 45 lbs |
| Width | 17.5 inches | 17.3 inches | 19 inches | 17.5 inches | 17.3 inches |
Every unit is authentic, sourced through trusted and authorised channels, and serial-verified on request. Genuine networking and IT hardware, guaranteed, or your money back.
New products are backed by up to 3 years of extended warranty, and certified refurbished units by up to 3 months, for dependable protection on every order. Coverage is clear, honoured in full, and confirmed on each product page.
If a unit ever falls short, our streamlined RMA process gets a replacement to you fast, with advance replacement available to keep your network running. No jargon, no runaround.
Every device is inspected, bench-tested, and firmware-verified, with configurations wiped before dispatch. Additional testing can be arranged to confirm full working condition on request.
Our specialists assist with compatibility, configuration, licensing, and installation, before and after you buy. Real hardware expertise, whenever you need it.
dispatched quickly and shipped worldwide from regional hubs, fully tracked and insured.
Strong single processor performance suitable for virtualization and databases.
Stable server with excellent RAID responsiveness.
Predictable throughput under continuous workloads.
Well balanced configuration for enterprise environments.
Meets expectations for performance focused deployments.
The HPE ProLiant DL380 Gen10 4114 is a 2U rack server featuring an Intel Xeon Silver 4114 2.2 GHz 10-core CPU, 32 GB DDR4 RAM, an HPE Smart Array P408i-a RAID controller, eight SFF drive bays and an 800 W Platinum hot-plug power supply.
This server ships with 32 GB DDR4 RDIMM memory across four DIMMs and supports up to 3 TB of DDR4 RDIMM or LRDIMM RAM in 24 slots for high-performance workloads.
It includes eight front-accessible SFF (2.5-inch) drive bays compatible with SAS, SATA or NVMe SSDs/HDDs and the P408i-a controller provides up to 12 Gb/s SAS connectivity.
It is powered by a single Intel Xeon Silver 4114 processor operating at 2.2 GHz with 10 cores (20 threads) and 13.75 MB L3 cache, delivering enterprise-grade performance.
The server is equipped with an 800 W HPE Flex Slot Platinum hot-plug power supply supporting N+1 redundancy for maximum uptime and energy efficiency.
Ideal for virtualization, database management, web serving, and cloud environments, this server balances compute, memory, storage and security for diverse workloads.
It supports VMware ESXi, Microsoft Hyper-V, Red Hat Virtualization, KVM and Citrix XenServer, ensuring broad compatibility for virtualized environments.
Install additional DDR4 RDIMMs or LRDIMMs in the 24 available DIMM slots, enabling memory scaling from the included 32 GB up to 3 TB for memory-intensive applications.
The P408i-a supports RAID 0, 1, 5, 6, 10, 50 and 60 for flexible data protection and performance optimization across all eight SFF drive bays.
Certified for Windows Server, Red Hat Enterprise Linux, SUSE Linux Enterprise Server, VMware ESXi, CentOS and Ubuntu, providing broad OS support.
Integrated HPE iLO 5 delivers remote administration, automated firmware updates, health monitoring, and scripting support for flat-score IT management.
Built-in HPE Silicon Root of Trust, Secure Boot, TPM 2.0, chassis intrusion detection and Secure Erase ensure server firmware and data integrity.
Includes a standard 3-year limited warranty with parts, labor and on-site support; options available to extend coverage and accelerate response times.
Equipped with an 800 W Platinum power supply and HPE Power Discovery Services, it achieves up to 94% efficiency and offers power capping for optimized energy use.
Ships with two integrated 1 GbE ports; supports optional FlexibleLOM and PCIe network cards for 10/25/40/100 GbE to meet varied bandwidth requirements.
Yes, it accommodates up to three single-wide or two double-wide GPUs in PCIe slots, enabling AI, machine learning and graphics-intensive workloads.
A 2U rack-mount server designed for data center and enterprise environments, compatible with standard 19-inch rack rails and tool-less installation kits.
United States
