United States
Name:
P06421-B21
- Description:
- HPE ProLiant DL380 Gen10 4114 2.2GHz 10-core 1P 32GB-R P408i-a 8SFF 800W PS Performance Server
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3 Year Extended Warranty
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Express Delivery Across the USA
Need it fast? Choose Express Shipping and receive your order within 1–3 business days.
Free Ground Shipping Available
Standard ground delivery across the U.S. takes 2–6 days, depending on your location — no extra charge.
International Shipments Made Simple
For all international orders, we ship via your UPS, FedEx, or DHL account — or to your U.S.-based freight forwarder.
Delivery Timelines
Under 100 KG? Ships Express.
Smaller shipments go via DHL or FedEx Express — delivered worldwide in approximately 3 business days.
Over 100 KG? Ships via Freight.
Larger orders are dispatched through freight forwarding partners. Delivery takes 7–10 business days, globally.
Always Delivered to Your Door
Every shipment is delivered directly to your address — regardless of country or carrier.
Our best-in-class warranties
3-Year Extended Warranty
Extended protection, enterprise-grade.
All enterprise hardware is backed by a 3-year warranty — triple the industry standard — covering defects under normal use.
Professional repairs & replacements.
If a hardware issue is confirmed, we’ll repair or replace the unit. Replacement parts carry either original or 3-month coverage.
RMA process, simplified.
Once an RMA is approved, return the defective unit within 10 days. We handle the rest — no service gaps.
Service Boundaries & Exclusions
What’s covered — and what’s best avoided.
Your warranty covers defects under normal use. For continued protection, avoid accidental damage, unauthorized repairs, third-party parts, or extreme environments.
Know your location’s service type.
In some regions, return-to-factory or remote service may apply. On-site service depends on infrastructure availability.
Minimal documentation required.
To initiate service, just submit the invoice and warranty card — no red tape, no waiting.
14-Day Money Back Guarantee
Free 14-Day Returns
Tested it, but it’s not a fit?
Return any product within 14 days of delivery if it doesn’t meet your technical or operational needs.
Initiate returns with ease.
Our RMA process is streamlined — just raise a request, follow the packaging guidelines, and we’ll handle the rest.
Refund or restock, your call.
Changed your mind? Get a refund (restocking fees may apply) or swap with another product.
30-Day Hardware Replacement
Covered for any early faults.
All equipment includes a 30-day replacement warranty. If something goes wrong, we’ll repair or swap it — fast.
Replacements shipped in 10 days or less.
Once your return is inspected and approved, we dispatch the replacement promptly to keep your operations moving.
RMA protocol keeps it smooth.
Just ensure all accessories and original packaging are intact — we’ll take care of the technical validation.
TRUSTED, TRIED, PROVEN
P06421-B21 Overview
P06421-B21 is a rackmount server that supports Intel Xeon Scalable 3rd Gen processors with an LGA 4189 socket, offering 2P CPU scalability. It features ECC DDR5 memory across 16 DIMM slots with a maximum capacity of 2 TB, 6 PCIe 4.0 expansion slots, and 8 available 3.5-inch storage bays supporting RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10 configurations.
P06421-B21 includes dual 10GbE network interfaces, redundant 1000W power supplies, active cooling, and iDRAC remote management. It officially supports operating systems such as Windows Server, VMware ESXi, and Ubuntu, making it ideal for data center, virtualization, file server, and application server use cases.
What is the price of P06421-B21?
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P06421-B21 Specifications
| Product Type | Server |
| Form Factor | Rackmount |
| Rack Units | 2U |
| Processor Brand | Intel |
| Processor Series | Intel Xeon Scalable |
| Processor Generation | Xeon 3rd Gen |
| Use Case | Virtualization / File Server / Application Server |
| CPU Socket | LGA 4189 |
| Scalability | 2P |
| Max Cores Per CPU | 32 |
| Max Threads Per CPU | 64 |
| RAM Type | ECC DDR5 |
| RAM Slots | 16 |
| Max RAM Capacity | 2 TB |
| Storage Type | SATA SSD |
| Storage Bays | 8 |
| Drive Bay Size | 3.5-inch |
| Hot-Swap Support | Yes |
| RAID Support | RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10 |
| PCIe Slots | 6 |
| PCIe Version | PCIe 4.0 |
| Network Interface | 10GbE |
| LAN Ports | 2 |
| Remote Management | iDRAC |
| Power Supply | Redundant |
| Power Supply Wattage | 1000W |
| Cooling | Active |
| Operating System | Windows Server / VMware ESXi / Ubuntu |
| Virtualization Ready | Yes |
| GPU Support | Yes |
| Rail Kit Included | No |
| Product Name | P06421-B21 |
| Height | 3.5 inches |
| Width | 17.5 inches |
| Depth | 28 inches |
| Weight | 45 lbs |
P06421-B21 Use Case
Enterprise VM Consolidation with HPE ProLiant DL380 Gen10
A mid-size data center migrates from multiple legacy servers to a single P06421-B21 HPE ProLiant DL380 Gen10 (Intel® Xeon® Silver 4114 2.2 GHz 10-core, 32 GB RDIMM, P408i-a RAID, 8 SFF bays, 800 W PSU) running VMware vSphere. Key benefits: • 40% reduction in rack space and power consumption • 35% faster VM provisioning and patching • Centralized management via HPE OneView Outcome: Lower total cost of ownership (TCO) and enhanced operational agility for business-critical workloads.
Accelerating Mission-Critical Database Workloads
A financial services firm deploys the P06421-B21 HPE ProLiant DL380 Gen10 for its SQL Server OLTP environment. With Intel® Xeon® Silver 4114, 32 GB memory, P408i-a RAID controller and 8 SFF SSDs, the server delivers high IOPS and sub-millisecond latency under peak load. Key benefits: • 50% faster query response times • 99.99% uptime with redundant power and HPE iLO monitoring • Seamless scalability with additional DIMMs and drives Outcome: Improved customer satisfaction and compliance through reliable, low-latency transaction processing.
High-Performance Data Analytics & AI Inference
A retail analytics team leverages the P06421-B21 HPE ProLiant DL380 Gen10 (Intel® Xeon® Silver 4114, 32 GB RDIMM, P408i-a, 8 SFF, 800 W) integrated with HPE InfoSight and containerized AI frameworks. The server processes large datasets and delivers real-time insights. Key benefits: • 3× faster AI model inference times • Predictive maintenance reducing downtime by 30% • Native integration with cloud AI services Outcome: Accelerated data-driven decision-making and increased revenue through personalized customer experiences.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table
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| Cooling | Active | Active | Active | Active | Active |
| CPU Socket | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 |
| Depth | 28.0 inches | 27 inches | 28.7 inches | 28 inches | 28.0 inches |
| Drive Bay Size | 3.5-inch | 3.5-inch | 2.5-inch | 3.5-inch | 3.5-inch |
| Form Factor | Rackmount | Rackmount | Rackmount / Tower | Rackmount | Rackmount |
| GPU Support | Yes | Yes | Yes | Yes | Yes |
| Height | 3.5 inches | 3.5 inches | 6.88 inches | 3.5 inches | 3.5 inches |
| Hot-Swap Support | Yes | Yes | Yes | Yes | Yes |
| LAN Ports | 2 | 4 | 4 | 2 | 2 |
| Max Cores per CPU | 32 | 32 | 32 | 32 | 32 |
| Max RAM Capacity | 2 TB | 1 TB | 2 TB | 2 TB | 1 TB |
| Max Threads per CPU | 64 | 64 | 64 | 64 | 64 |
| Network Interface | 10GbE | 10GbE | 10GbE | 10GbE | 10GbE |
| Operating System | Windows Server / VMware ESXi / Ubuntu | Windows Server | Windows Server / VMware ESXi / Ubuntu | Windows Server / VMware ESXi / Ubuntu | Windows Server / VMware ESXi / Ubuntu / RHEL |
| PCIe Slots | 4 | 4 | 6 | 6 | 4 |
| PCIe Version | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 |
| Power Supply | Redundant | Redundant | Redundant | Redundant | Redundant |
| Power Supply Wattage | 800W | 1200W | 800W | 1000W | 750W |
| Processor Brand | Intel | Intel | Intel | Intel | Intel |
| Processor Generation | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 4th Gen |
| Processor Series | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable |
| Product Name | 868705-B21 Server System | 752687-B21 Enterprise Rack Server | P05524-B21 | P06421-B21 | Q9A06A Enterprise Server |
| Product Type | Server | Server | Server | Server | Server |
| Rack Units | 2U | 2U | 2U | 2U | 2U |
| RAID Support | RAID 0 / RAID 1 / RAID 10 | RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10 |
| Rail Kit Included | No | Yes | Yes | No | N/A |
| RAM Slots | 16 | 8 | 16 | 16 | 16 |
| RAM Type | ECC DDR5 | ECC DDR4 | ECC DDR4 | ECC DDR5 | ECC DDR4 |
| Remote Management | iDRAC | iDRAC | iDRAC | iDRAC | iDRAC |
| Scalability | 2P | 2P | 2P | 2P | 2P |
| Storage Bays | 8 | 8 | 8 | 8 | 4 |
| Storage Type | SATA SSD | SATA SSD | SAS HDD | SATA SSD | Hybrid |
| Use Case | Virtualization / File Server / Application Server | Virtualization | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server |
| Virtualization Ready | Yes | Yes | Yes | Yes | Yes |
| Weight | 50 lbs | 60 lbs | 55 lbs | 45 lbs | 45 lbs |
| Width | 17.5 inches | 19 inches | 17.3 inches | 17.5 inches | 17.3 inches |
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Questions & Answers
Q
What are the key specifications of the HPE ProLiant DL380 Gen10 4114 Performance Server?
A
The HPE ProLiant DL380 Gen10 4114 is a 2U rack server featuring an Intel Xeon Silver 4114 2.2 GHz 10-core CPU, 32 GB DDR4 RAM, an HPE Smart Array P408i-a RAID controller, eight SFF drive bays and an 800 W Platinum hot-plug power supply.
Q
How much memory does the DL380 Gen10 4114 server include and support?
A
This server ships with 32 GB DDR4 RDIMM memory across four DIMMs and supports up to 3 TB of DDR4 RDIMM or LRDIMM RAM in 24 slots for high-performance workloads.
Q
What storage options are available in the HPE ProLiant DL380 Gen10 4114?
A
It includes eight front-accessible SFF (2.5-inch) drive bays compatible with SAS, SATA or NVMe SSDs/HDDs and the P408i-a controller provides up to 12 Gb/s SAS connectivity.
Q
Which processor powers the HPE DL380 Gen10 4114?
A
It is powered by a single Intel Xeon Silver 4114 processor operating at 2.2 GHz with 10 cores (20 threads) and 13.75 MB L3 cache, delivering enterprise-grade performance.
Q
What power supply does the DL380 Gen10 4114 use?
A
The server is equipped with an 800 W HPE Flex Slot Platinum hot-plug power supply supporting N+1 redundancy for maximum uptime and energy efficiency.
Q
What are the primary use cases for the HPE ProLiant DL380 Gen10 4114?
A
Ideal for virtualization, database management, web serving, and cloud environments, this server balances compute, memory, storage and security for diverse workloads.
Q
Which virtualization platforms are supported on the DL380 Gen10 4114?
A
It supports VMware ESXi, Microsoft Hyper-V, Red Hat Virtualization, KVM and Citrix XenServer, ensuring broad compatibility for virtualized environments.
Q
How can I expand memory capacity in the DL380 Gen10?
A
Install additional DDR4 RDIMMs or LRDIMMs in the 24 available DIMM slots, enabling memory scaling from the included 32 GB up to 3 TB for memory-intensive applications.
Q
What RAID levels does the HPE Smart Array P408i-a controller support?
A
The P408i-a supports RAID 0, 1, 5, 6, 10, 50 and 60 for flexible data protection and performance optimization across all eight SFF drive bays.
Q
Which operating systems are compatible with the DL380 Gen10 4114?
A
Certified for Windows Server, Red Hat Enterprise Linux, SUSE Linux Enterprise Server, VMware ESXi, CentOS and Ubuntu, providing broad OS support.
Q
What management features are included with the DL380 Gen10?
A
Integrated HPE iLO 5 delivers remote administration, automated firmware updates, health monitoring, and scripting support for flat-score IT management.
Q
What security features protect the HPE ProLiant DL380 Gen10?
A
Built-in HPE Silicon Root of Trust, Secure Boot, TPM 2.0, chassis intrusion detection and Secure Erase ensure server firmware and data integrity.
Q
What warranty and support come with the DL380 Gen10 4114?
A
Includes a standard 3-year limited warranty with parts, labor and on-site support; options available to extend coverage and accelerate response times.
Q
How energy efficient is the HPE ProLiant DL380 Gen10?
A
Equipped with an 800 W Platinum power supply and HPE Power Discovery Services, it achieves up to 94% efficiency and offers power capping for optimized energy use.
Q
What networking options are available for this server?
A
Ships with two integrated 1 GbE ports; supports optional FlexibleLOM and PCIe network cards for 10/25/40/100 GbE to meet varied bandwidth requirements.
Q
Does the DL380 Gen10 support GPU accelerators?
A
Yes, it accommodates up to three single-wide or two double-wide GPUs in PCIe slots, enabling AI, machine learning and graphics-intensive workloads.
Q
What is the form factor and deployment environment for the DL380 Gen10?
A
A 2U rack-mount server designed for data center and enterprise environments, compatible with standard 19-inch rack rails and tool-less installation kits.
