United States$5,000,000+
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E
Elliot Hardwick
5
Strong single processor performance suitable for virtualization and databases.
P06421-B21
HPE ProLiant DL380 Gen10 4114 2.2GHz 10-core 1P 32GB-R P408i...
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P06421-B21
- Description:
- HPE ProLiant DL380 Gen10 4114 2.2GHz 10-core 1P 32GB-R P408i-a 8SFF 800W PS Performance Server
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P06421-B21 Overview
P06421-B21 is a rackmount server that supports Intel Xeon Scalable 3rd Gen processors with an LGA 4189 socket, offering 2P CPU scalability. It features ECC DDR5 memory across 16 DIMM slots with a maximum capacity of 2 TB, 6 PCIe 4.0 expansion slots, and 8 available 3.5-inch storage bays supporting RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10 configurations.
P06421-B21 includes dual 10GbE network interfaces, redundant 1000W power supplies, active cooling, and iDRAC remote management. It officially supports operating systems such as Windows Server, VMware ESXi, and Ubuntu, making it ideal for data center, virtualization, file server, and application server use cases.
P06421-B21 price is is available on request. Get immediate quote.
Request bulk order quote for P06421-B21 for additional pricing. Browse the full Hpe Proliant Dl380 Gen10 Servers series or explore all Hpe products.
P06421-B21 Specifications
- Product Type
- Server
- Form Factor
- Rackmount
- Rack Units
- 2U
- Processor Brand
- Intel
- Processor Series
- Intel Xeon Scalable
- Processor Generation
- Xeon 3rd Gen
- Use Case
- Virtualization / File Server / Application Server
- CPU Socket
- LGA 4189
- Scalability
- 2P
- Max Cores per CPU
- 32
- Max Threads per CPU
- 64
- RAM Type
- ECC DDR5
- RAM Slots
- 16
- Max RAM Capacity
- 2 TB
- Storage Type
- SATA SSD
- Storage Bays
- 8
- Drive Bay Size
- 3.5-inch
- Hot-Swap Support
- Yes
- RAID Support
- RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10
- PCIe Slots
- 6
- PCIe Version
- PCIe 4.0
- Network Interface
- 10GbE
- LAN Ports
- 2
- Remote Management
- iDRAC
- Power Supply
- Redundant
- Power Supply Wattage
- 1000W
- Cooling
- Active
- Operating System
- Windows Server / VMware ESXi / Ubuntu
- Virtualization Ready
- Yes
- GPU Support
- Yes
- Rail Kit Included
- No
- Product Name
- P06421-B21
- Height
- 3.5 inches
- Width
- 17.5 inches
- Depth
- 28 inches
- Weight
- 45 lbs
P06421-B21 Use Case
Enterprise VM Consolidation with HPE ProLiant DL380 Gen10
A mid-size data center migrates from multiple legacy servers to a single P06421-B21 HPE ProLiant DL380 Gen10 (Intel® Xeon® Silver 4114 2.2 GHz 10-core, 32 GB RDIMM, P408i-a RAID, 8 SFF bays, 800 W PSU) running VMware vSphere. Key benefits: • 40% reduction in rack space and power consumption • 35% faster VM provisioning and patching • Centralized management via HPE OneView Outcome: Lower total cost of ownership (TCO) and enhanced operational agility for business-critical workloads.
Accelerating Mission-Critical Database Workloads
A financial services firm deploys the P06421-B21 HPE ProLiant DL380 Gen10 for its SQL Server OLTP environment. With Intel® Xeon® Silver 4114, 32 GB memory, P408i-a RAID controller and 8 SFF SSDs, the server delivers high IOPS and sub-millisecond latency under peak load. Key benefits: • 50% faster query response times • 99.99% uptime with redundant power and HPE iLO monitoring • Seamless scalability with additional DIMMs and drives Outcome: Improved customer satisfaction and compliance through reliable, low-latency transaction processing.
High-Performance Data Analytics & AI Inference
A retail analytics team leverages the P06421-B21 HPE ProLiant DL380 Gen10 (Intel® Xeon® Silver 4114, 32 GB RDIMM, P408i-a, 8 SFF, 800 W) integrated with HPE InfoSight and containerized AI frameworks. The server processes large datasets and delivers real-time insights. Key benefits: • 3× faster AI model inference times • Predictive maintenance reducing downtime by 30% • Native integration with cloud AI services Outcome: Accelerated data-driven decision-making and increased revenue through personalized customer experiences.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table
 P06421-B21 |  P05524-B21 |  752687-B21 |  868705-B21 |  Q9A06A | |
|---|---|---|---|---|---|
| CPU Socket | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 |
| Cooling | Active | Active | Active | Active | Active |
| Depth | 28 inches | 28.7 inches | 27 inches | 28.0 inches | 28.0 inches |
| Drive Bay Size | 3.5-inch | 2.5-inch | 3.5-inch | 3.5-inch | 3.5-inch |
| Form Factor | Rackmount | Rackmount / Tower | Rackmount | Rackmount | Rackmount |
| GPU Support | Yes | Yes | Yes | Yes | Yes |
| Height | 3.5 inches | 6.88 inches | 3.5 inches | 3.5 inches | 3.5 inches |
| Hot-Swap Support | Yes | Yes | Yes | Yes | Yes |
| LAN Ports | 2 | 4 | 4 | 2 | 2 |
| Max Cores per CPU | 32 | 32 | 32 | 32 | 32 |
| Max RAM Capacity | 2 TB | 2 TB | 1 TB | 2 TB | 1 TB |
| Max Threads per CPU | 64 | 64 | 64 | 64 | 64 |
| Network Interface | 10GbE | 10GbE | 10GbE | 10GbE | 10GbE |
| Operating System | Windows Server / VMware ESXi / Ubuntu | Windows Server / VMware ESXi / Ubuntu | Windows Server | Windows Server / VMware ESXi / Ubuntu | Windows Server / VMware ESXi / Ubuntu / RHEL |
| PCIe Slots | 6 | 6 | 4 | 4 | 4 |
| PCIe Version | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 |
| Power Supply | Redundant | Redundant | Redundant | Redundant | Redundant |
| Power Supply Wattage | 1000W | 800W | 1200W | 800W | 750W |
| Processor Brand | Intel | Intel | Intel | Intel | Intel |
| Processor Generation | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 4th Gen |
| Processor Series | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable |
| Product Name | P06421-B21 | P05524-B21 | 752687-B21 Enterprise Rack Server | 868705-B21 Server System | Q9A06A Enterprise Server |
| Product Type | Server | Server | Server | Server | Server |
| RAID Support | RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 10 | RAID 10 | RAID 0 / RAID 1 / RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10 |
| RAM Slots | 16 | 16 | 8 | 16 | 16 |
| RAM Type | ECC DDR5 | ECC DDR4 | ECC DDR4 | ECC DDR5 | ECC DDR4 |
| Rack Units | 2U | 2U | 2U | 2U | 2U |
| Rail Kit Included | No | Yes | Yes | No | N/A |
| Remote Management | iDRAC | iDRAC | iDRAC | iDRAC | iDRAC |
| Scalability | 2P | 2P | 2P | 2P | 2P |
| Storage Bays | 8 | 8 | 8 | 8 | 4 |
| Storage Type | SATA SSD | SAS HDD | SATA SSD | SATA SSD | Hybrid |
| Use Case | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server | Virtualization | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server |
| Virtualization Ready | Yes | Yes | Yes | Yes | Yes |
| Weight | 45 lbs | 55 lbs | 60 lbs | 50 lbs | 45 lbs |
| Width | 17.5 inches | 17.3 inches | 19 inches | 17.5 inches | 17.3 inches |
Reviews & Ratings
F
Faisal Nadeem
4
Stable server with excellent RAID responsiveness.
B
Baptiste Renard
5
Predictable throughput under continuous workloads.
H
Henry Callow
3
Well balanced configuration for enterprise environments.
Z
Zubair Yasin
4
Meets expectations for performance focused deployments.
Questions & Answers
What are the key specifications of the HPE ProLiant DL380 Gen10 4114 Performance Server?
The HPE ProLiant DL380 Gen10 4114 is a 2U rack server featuring an Intel Xeon Silver 4114 2.2 GHz 10-core CPU, 32 GB DDR4 RAM, an HPE Smart Array P408i-a RAID controller, eight SFF drive bays and an 800 W Platinum hot-plug power supply.
How much memory does the DL380 Gen10 4114 server include and support?
This server ships with 32 GB DDR4 RDIMM memory across four DIMMs and supports up to 3 TB of DDR4 RDIMM or LRDIMM RAM in 24 slots for high-performance workloads.
What storage options are available in the HPE ProLiant DL380 Gen10 4114?
It includes eight front-accessible SFF (2.5-inch) drive bays compatible with SAS, SATA or NVMe SSDs/HDDs and the P408i-a controller provides up to 12 Gb/s SAS connectivity.
Which processor powers the HPE DL380 Gen10 4114?
It is powered by a single Intel Xeon Silver 4114 processor operating at 2.2 GHz with 10 cores (20 threads) and 13.75 MB L3 cache, delivering enterprise-grade performance.