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CTO server provides flexibility for custom builds.
P18606-B21
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HPE ProLiant DL325 Gen10 Plus CTO Server
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P18606-B21
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- HPE ProLiant DL325 Gen10 Plus CTO Server
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P18606-B21 Overview
P18606-B21 is a high-performance rackmount server designed for data center and virtualization environments. It supports Intel Xeon Scalable processors (3rd Gen) on an LGA 4189 socket with 2P scalability, accommodates ECC DDR4 memory in 16 slots up to a total of 2 TB, and offers 4 PCIe 4.0 expansion slots. The server provides 8 hot-swap 3.5-inch storage bays with RAID 0/RAID 1/RAID 10 support, ensuring high availability and data protection.
P18606-B21 features integrated networking with 4 x 1GbE LAN ports, redundant 750W power supplies, active cooling, and remote management via iDRAC. It officially supports operating systems such as VMware ESXi, Windows Server, and Ubuntu, making it ideal for use as a file server, application server, or in virtualization deployments.
P18606-B21 price is is available on request. Get immediate quote.
Request bulk order quote for P18606-B21 for additional pricing. Browse the full Hpe Proliant Dl325 Gen10 Plus Servers series or explore all Hpe products.
P18606-B21 Specifications
- Product Type
- Server
- Form Factor
- Rackmount
- Rack Units
- 2U
- Processor Brand
- Intel
- Processor Series
- Intel Xeon Scalable
- Processor Generation
- Xeon 3rd Gen
- Use Case
- Virtualization
- CPU Socket
- LGA 4189
- Scalability
- 2P
- Max Cores per CPU
- 32
- Max Threads per CPU
- 64
- RAM Type
- ECC DDR4
- RAM Slots
- 16
- Max RAM Capacity
- 2 TB
- Storage Type
- SATA HDD
- Storage Bays
- 8
- Drive Bay Size
- 3.5-inch
- Hot-Swap Support
- Yes
- RAID Support
- RAID 0 / RAID 1 / RAID 10
- PCIe Slots
- 4
- PCIe Version
- PCIe 4.0
- Network Interface
- 1GbE
- LAN Ports
- 4
- Remote Management
- iDRAC
- Power Supply
- Redundant
- Power Supply Wattage
- 750W
- Cooling
- Active
- Operating System
- VMware ESXi
- Virtualization Ready
- Yes
- GPU Support
- Yes
- Rail Kit Included
- Yes
- Product Name
- P18606-B21 High-Performance Rack Server
- Height
- 3.5 inches
- Width
- 19 inches
- Depth
- 28 inches
- Weight
- 65 lbs
P18606-B21 Use Case
High-Density Virtualization Consolidation with HPE ProLiant DL325 Gen10 Plus
A mid-sized financial services firm deploys the P18606-B21 HPE ProLiant DL325 Gen10 Plus CTO Server to consolidate 60+ VMware® virtual machines onto a single AMD EPYC™-powered node. This real-world scenario reduces rack-space utilization by 50%, cuts software licensing fees by 30%, and accelerates VM provisioning by 2×, delivering enterprise-grade uptime and a 20% lower total cost of ownership (TCO).
Edge AI Inference for Retail Analytics with HPE ProLiant DL325 Gen10 Plus
A national retail chain integrates the P18606-B21 HPE ProLiant DL325 Gen10 Plus CTO Server at 100 store-level edge sites to run real-time video analytics and inventory-tracking AI models. The AMD EPYC™ processor delivers sub-10ms inference latency, enabling automatic checkout, dynamic shelving alerts, and 15% uplift in customer engagement while maintaining 99.9% availability and streamlined remote management via HPE iLO.
Secure Containerized Database Workloads on HPE ProLiant DL325 Gen10 Plus
A regulated healthcare provider implements the P18606-B21 HPE ProLiant DL325 Gen10 Plus CTO Server to host containerized PostgreSQL® and MongoDB® clusters under FIPS-compliant encryption. Silicon Root of Trust and Runtime Firmware Verification ensure zero-touch validation, delivering sub-4ms query response times, 3× faster backup/recovery, and full HIMSS Level 3 compliance—empowering secure, high-performance patient data management.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table 
| P18606-B21 |  P18604-B21 |  P15735-B21 |  P15535-B21 |  P18605-B21 | |
|---|---|---|---|---|---|
| CPU Socket | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 |
| Cooling | Active | Active | Active | Active | Active |
| Depth | 28 inches | 28.0 inches | 29 inches | 28.0 inches | 28 inches |
| Drive Bay Size | 3.5-inch | 3.5-inch | 3.5-inch | Mixed | 3.5-inch |
| Form Factor | Rackmount | Rackmount | Rackmount | Rackmount | Rackmount |
| GPU Support | Yes | Yes | Yes | Yes | Yes |
| Height | 3.5 inches | 3.5 inches | 3.5 inches | 3.5 inches | 3.5 inches |
| Hot-Swap Support | Yes | Yes | Yes | Yes | Yes |
| LAN Ports | 4 | 2 | 2 | 4 | 2 |
| Max Cores per CPU | 32 | 32 | 32 | 32 | 32 |
| Max RAM Capacity | 2 TB | 1 TB | 2 TB | 2 TB | 1 TB |
| Max Threads per CPU | 64 | 64 | 64 | 64 | 64 |
| Network Interface | 1GbE | 10GbE | 10GbE | 10GbE | 10GbE |
| Operating System | VMware ESXi | Windows Server / VMware ESXi / Ubuntu / RHEL / SUSE / CentOS | VMware ESXi | VMware ESXi | VMware ESXi |
| PCIe Slots | 4 | 4 | 4 | 4 | 4 |
| PCIe Version | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 |
| Power Supply | Redundant | Redundant | Redundant | Redundant | Redundant |
| Power Supply Wattage | 750W | 1600W | 800W | 1200W | 1200W |
| Processor Brand | Intel | Intel | Intel | Intel | Intel |
| Processor Generation | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 4th Gen | Xeon 3rd Gen | Xeon 4th Gen |
| Processor Series | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable |
| Product Name | P18606-B21 High-Performance Rack Server | P18604-B21 | P15735-B21 High Performance Rack Server | P15535-B21 Enterprise Server | P18605-B21 Server |
| Product Type | Server | Server | Server | Server | Server |
| RAID Support | RAID 0 / RAID 1 / RAID 10 | RAID 5 | RAID 5 | RAID 10 | RAID 10 |
| RAM Slots | 16 | 16 | 16 | 16 | 16 |
| RAM Type | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 |
| Rack Units | 2U | 2U | 2U | 2U | 2U |
| Rail Kit Included | Yes | N/A | No | Yes | Yes |
| Remote Management | iDRAC | iDRAC | iDRAC | iDRAC | iDRAC |
| Scalability | 2P | 2P | 2P | 2P | 2P |
| Storage Bays | 8 | 8 | 8 | 8 | 8 |
| Storage Type | SATA HDD | SATA HDD | SATA HDD | NVMe SSD | SATA SSD |
| Use Case | Virtualization | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server | Virtualization | Virtualization |
| Virtualization Ready | Yes | Yes | Yes | Yes | Yes |
| Weight | 65 lbs | 60 lbs | 60 lbs | 75 lbs | 45 lbs |
| Width | 19 inches | 17.3 inches | 17.2 inches | 17.2 inches | 17.5 inches |
Reviews & Ratings
Z
Zain Malik
5
Stable base platform for enterprise use.
J
Jens Holm
5
Good build quality and reliability.
C
Chris Nolan
5
Integrated easily into our environment.
V
Victor Paredes
5
Dependable server choice.
Questions & Answers
What is the HPE ProLiant DL325 Gen10 Plus CTO Server (SKU: P18606-B21)?
The HPE ProLiant DL325 Gen10 Plus CTO Server (SKU: P18606-B21) is a 1U rack-optimized, customizable server featuring AMD EPYC processors, designed for high-density virtualization and data-intensive workloads.
Which processors are supported by this CTO configuration?
This CTO server supports up to two AMD EPYC 7003 Series processors, delivering up to 64 cores per socket and advanced security features for demanding enterprise applications.
What is the maximum memory capacity?
The DL325 Gen10 Plus CTO supports up to 32 DIMM slots of DDR4 SmartMemory, providing up to 4 TB of memory at speeds up to 3200 MT/s for memory-intensive workloads.
What internal storage options are available?
You can configure the server with up to eight NVMe SSDs or sixteen SFF SAS/SATA drives, enabling flexible high-performance or high-capacity storage solutions.
Which RAID controllers are compatible?
The HPE Smart Array P408i-u with 12 Gb/s SAS and optional cache modules supports RAID 0, 1, 5, 6, 10, 50, and 60 for robust data protection and performance.
What networking features does the server offer?
Standard configurations include FlexibleLOM slots supporting up to 25 GbE adapters, with optional OCP 3.0 mezzanine cards for up to 100 GbE connectivity.
How is system management handled?
Integrated HPE iLO 5 management provides automated firmware updates, remote console, health monitoring, and scripting for streamlined server provisioning and maintenance.
Which security features are built in?
Security features include Silicon Root of Trust, Secure Boot, Runtime Firmware Validation, and TPM 2.0 to ensure firmware integrity and protect against cyber threats.
What power supplies and efficiency ratings are available?
The server supports redundant hot-plug PSUs in 500 W, 800 W, or 1600 W Platinum efficiency configurations to balance power efficiency and redundancy needs.
What are the physical dimensions and form factor?
This is a 1U rack server measuring 1.7” (H) x 17.5” (W) x 28.8” (D) and weighing approximately 30 lbs (13.6 kg) in its base configuration.
Which operating systems are supported?
The DL325 Gen10 Plus CTO is certified for major OSes including VMware ESXi, Microsoft Windows Server, Red Hat Enterprise Linux, SUSE Linux Enterprise Server, and Ubuntu LTS releases.
What virtualization platforms are recommended?
This server excels with VMware vSphere, Microsoft Hyper-V, and Red Hat Virtualization, offering optimized performance for dense virtual machine deployments.
What expansion capabilities does it offer?
You get three PCIe 4.0 slots plus one OCP 3.0 mezzanine slot, allowing for network, storage, or GPU card expansion to meet evolving workload demands.
What workloads are ideal for this server?
The DL325 Gen10 Plus CTO is ideal for virtualization, database acceleration, software-defined storage, HPC, and edge compute scenarios requiring high core counts and memory.
How does this model differ from the Gen10 server?
Compared to Gen10, the Gen10 Plus offers PCIe 4.0, higher memory speeds, enhanced iLO 5 security, and support for AMD EPYC 7003 processors for improved performance and efficiency.
What custom configuration options are available?
As a CTO model, you can tailor CPUs, memory, storage, network adapters, RAID controllers, and power supplies to match specific performance, capacity, and budget requirements.