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CTO rack server provides excellent configuration flexibility.
754534-B21
HPE ML350R09 SFF CTO Server
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754534-B21
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- HPE ML350R09 SFF CTO Server
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754534-B21 Overview
754534-B21 is a high-performance rackmount server engineered for demanding data center environments. It is powered by Intel Xeon Scalable processors on an LGA 4189 socket and supports dual-processor (2P) scalability, making it ideal for virtualization and application serving. The server comes equipped with ECC DDR4 memory supporting up to 256 GB via 8 slots, 6 PCIe expansion slots, and 8 hot-swap 2.5-inch drive bays with comprehensive RAID support (RAID 0, RAID 1, RAID 5, and RAID 10) to ensure high data availability and performance.
754534-B21 also features dual 10GbE network interfaces, redundant 750W power supplies, active cooling, and integrated remote management through iDRAC, providing robust out-of-band management capabilities. It is certified for leading operating systems such as Windows Server, VMware ESXi, and Ubuntu, making it an ideal choice for data centers, virtualization, file server, and application server deployments.
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Request bulk order quote for 754534-B21 for additional pricing. Browse the full Hpe Proliant Ml350 Gen9/10 Servers series or explore all Hpe products.
754534-B21 Specifications
- Product Type
- Server
- Form Factor
- Rackmount
- Rack Units
- 2U
- Processor Brand
- Intel
- Processor Series
- Intel Xeon Scalable
- Processor Generation
- Xeon 3rd Gen
- Use Case
- Virtualization
- CPU Socket
- LGA 4189
- Scalability
- 2P
- Max Cores per CPU
- 16
- Max Threads per CPU
- 32
- RAM Type
- ECC DDR4
- RAM Slots
- 8
- Max RAM Capacity
- 256 GB
- Storage Type
- SATA SSD
- Storage Bays
- 8
- Drive Bay Size
- 2.5-inch
- Hot-Swap Support
- Yes
- RAID Support
- RAID 0 / RAID 1 / RAID 5 / RAID 10
- PCIe Slots
- 6
- PCIe Version
- PCIe 4.0
- Network Interface
- 10GbE
- LAN Ports
- 2
- Remote Management
- iDRAC
- Power Supply
- Redundant
- Power Supply Wattage
- 750W
- Cooling
- Active
- Operating System
- Windows Server
- Virtualization Ready
- Yes
- GPU Support
- Yes
- Rail Kit Included
- N/A
- Product Name
- 754534-B21
- Height
- 3.5 inches
- Width
- 17.5 inches
- Depth
- 28.0 inches
- Weight
- 45 lbs
754534-B21 Use Case
Enterprise Virtualization Consolidation with HPE ML350R09 SFF CTO Server
In a mid-sized financial services firm, IT teams deploy the 754534-B21 HPE ML350R09 SFF CTO Server as a VMware ESXi host to consolidate 20+ virtual machines into a single chassis. Leveraging dual Intel® Xeon® Scalable processors, 2666 MHz DDR4 memory and redundant power supplies, the solution delivers 40% reduction in rack footprint, 25% lower energy costs and 99.99% uptime for mission-critical applications.
High-Performance SQL Database for E-Commerce
An online retailer uses the 754534-B21 HPE ML350R09 SFF CTO Server to run Microsoft SQL Server 2019 for its order-processing engine, handling 10,000+ transactions per hour with sub-10 ms query latency. With SFF SAS drives in RAID 1+0, NVMe caching and 32 GB ECC memory, the configuration accelerates transaction throughput by 3×, ensures zero data loss and supports peak-season scalability.
Edge Compute & Backup for Remote Offices
A global retail chain deploys the 754534-B21 HPE ML350R09 SFF CTO Server at branch locations to deliver file services, local analytics and on-site backup. Featuring integrated 10 GbE ports, HPE StoreEasy integration and 24×7 HPE Pointnext Support, each server provides fast local data access, automated replication to headquarters and 30-minute hardware replacement, boosting branch performance and data resilience.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table
 754534-B21 |  P11050-001 |  878767-S01 |  P11052-001 |  835263-001 | |
|---|---|---|---|---|---|
| CPU Socket | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 |
| Cooling | Active | Active | Active | Active | Active |
| Depth | 28.0 inches | 27.6 inches | 28 inches | 28.0 inches | 28 inches |
| Drive Bay Size | 2.5-inch | Mixed | 2.5-inch | 2.5-inch | Mixed |
| Form Factor | Rackmount | Rackmount | Rackmount | Rackmount | Rackmount |
| GPU Support | Yes | Yes | Yes | Yes | Yes |
| Height | 3.5 inches | 3.5 inches | 3.5 inches | 3.5 inches | 3.5 inches |
| Hot-Swap Support | Yes | Yes | Yes | Yes | Yes |
| LAN Ports | 2 | 4 | 4 | 2 | 4 |
| Max Cores per CPU | 16 | 48 | 32 | 32 | 32 |
| Max RAM Capacity | 256 GB | 1 TB | 2 TB | 1 TB | 1 TB |
| Max Threads per CPU | 32 | 64 | 64 | 64 | 64 |
| Network Interface | 10GbE | 10GbE | 10GbE | 10GbE | 10GbE |
| Operating System | Windows Server | VMware ESXi | Windows Server | VMware ESXi | Ubuntu |
| PCIe Slots | 6 | 4 | 4 | 4 | 4 |
| PCIe Version | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 |
| Power Supply | Redundant | Redundant | Redundant | Redundant | Redundant |
| Power Supply Wattage | 750W | 1000W | 1200W | 750W | 1000W |
| Processor Brand | Intel | Intel | Intel | Intel | Intel |
| Processor Generation | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 4th Gen | Xeon 3rd Gen | Xeon 3rd Gen |
| Processor Series | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable |
| Product Name | 754534-B21 | P11050-001 | 878767-S01 Enterprise Server | P11052-001 High Performance Rackmount Server | 835263-001 Enterprise Rackmount Server |
| Product Type | Server | Server | Server | Server | Server |
| RAID Support | RAID 0 / RAID 1 / RAID 5 / RAID 10 | RAID 10 | RAID 10 | RAID 0 / RAID 1 / RAID 10 | RAID 10 |
| RAM Slots | 8 | 16 | 16 | 16 | 12 |
| RAM Type | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 |
| Rack Units | 2U | 2U | 2U | 2U | 2U |
| Rail Kit Included | N/A | Yes | Yes | Yes | Yes |
| Remote Management | iDRAC | iDRAC | iDRAC | iDRAC | iDRAC |
| Scalability | 2P | 2P | 2P | 2P | 2P |
| Storage Bays | 8 | 8 | 8 | 8 | 8 |
| Storage Type | SATA SSD | SATA SSD | NVMe SSD | SATA SSD | Hybrid |
| Use Case | Virtualization | Virtualization | Virtualization | Virtualization | Virtualization |
| Virtualization Ready | Yes | Yes | Yes | Yes | Yes |
| Weight | 45 lbs | 45 lbs | 45 lbs | 45 lbs | 50 lbs |
| Width | 17.5 inches | 17.2 inches | 17.5 inches | 17.2 inches | 17 inches |
Reviews & Ratings
H
Hamza Waleed
4
Stable platform for custom enterprise builds.
J
Jonas Pettersson
5
Reliable once configured to requirements.
E
Edward Collinsby
3
Good airflow and cooling design.
F
Faheem Yasin
4
Consistent performance after deployment.
Questions & Answers
What are the key specifications of the HPE ML350R09 SFF CTO Server?
The HPE ML350R09 SFF CTO Server features dual Intel® Xeon® processor support, up to 1.5 TB DDR4 memory, eight SFF drive bays, two PCIe 3.0 expansion slots, integrated HPE iLO 4 remote management, and redundant hot-swap power supplies.
Which processors are compatible with the HPE ML350R09 SFF CTO Server?
The ML350R09 supports the Intel Xeon E5-2600 v3 and v4 product families, including up to two 22-core CPUs for optimized performance and scalability.
What is the maximum memory capacity of the ML350R09 server?
This server accommodates up to 24 DDR4 DIMM slots, delivering a maximum of 1.5 TB of RDIMM or LRDIMM memory for demanding applications.
What storage options does the HPE ML350R09 offer?
The system supports eight SFF hot-plug drive bays with SATA, SAS, or NVMe SSD options, plus an optional five-drive NLSAS cage for up to 13 total SFF drives.