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877626-B21
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- HPE ML350 Gen10 SFF CTO Server
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877626-B21 Overview
877626-B21 is a rackmount server that supports Intel Xeon Scalable processors with an LGA 4189 socket and offers 2P CPU scalability. It accommodates ECC DDR4 memory up to 1 TB across 16 DIMM slots, provides 4 PCIe expansion slots, and features 8 hot-swap 2.5-inch storage bays with RAID 0, RAID 1, RAID 5, and RAID 10 support.
This product is equipped with dual redundant 800W power supplies, active cooling, and remote management via iDRAC. It integrates 4 x 1GbE network interfaces, supports operating systems such as Windows Server, VMware ESXi, and RHEL, and is ideally suited for data center virtualization, file serving, and application hosting use cases.
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877626-B21 Specifications
| Product Type | Server |
| Form Factor | Rackmount |
| Rack Units | 2U |
| Processor Brand | Intel |
| Processor Series | Intel Xeon Scalable |
| Processor Generation | Xeon 3rd Gen |
| Use Case | Virtualization |
| CPU Socket | LGA 4189 |
| Scalability | 2P |
| Max Cores Per CPU | 32 |
| Max Threads Per CPU | 64 |
| RAM Type | ECC DDR4 |
| RAM Slots | 16 |
| Max RAM Capacity | 1 TB |
| Storage Type | SATA SSD |
| Storage Bays | 8 |
| Drive Bay Size | 2.5-inch |
| Hot-Swap Support | Yes |
| RAID Support | RAID 0 / RAID 1 / RAID 5 / RAID 10 |
| PCIe Slots | 4 |
| PCIe Version | PCIe 4.0 |
| Network Interface | 1GbE |
| LAN Ports | 4 |
| Remote Management | iDRAC |
| Power Supply | Redundant |
| Power Supply Wattage | 800W |
| Cooling | Active |
| Operating System | Windows Server |
| Virtualization Ready | Yes |
| GPU Support | No |
| Rail Kit Included | Yes |
| Product Name | 877626-B21 |
| Height | 3.5 inches |
| Width | 17.3 inches |
| Depth | 28.0 inches |
| Weight | 45 lbs |
877626-B21 Use Case
Enterprise Virtualization Consolidation with HPE ML350 Gen10 SFF CTO Server
In a mid-sized financial services firm, IT teams deploy the 877626-B21 HPE ML350 Gen10 SFF CTO Server as a VMware ESXi host to consolidate 20+ critical Windows and Linux VMs onto a single chassis. This reduces rack-space footprint by 60%, cuts power costs by 30%, and delivers sub-millisecond response times for front-office trading applications, driving a 2× improvement in overall infrastructure ROI.
High-Performance SQL and NoSQL Database Hosting
A healthcare analytics provider implements the HPE ML350 Gen10 SFF CTO Server (877626-B21) to run mixed OLTP/OLAP workloads on Microsoft SQL Server and MongoDB, leveraging 8 NVMe drives and dual Intel Xeon Scalable CPUs. The result is sustained 150,000 IOPS, sub-millisecond query latency, and 99.99% uptime—empowering timely patient data insights while meeting stringent HIPAA and uptime SLAs.
Remote Office/Branch Infrastructure & Hybrid Cloud Integration
A global retail chain deploys the HPE ML350 Gen10 SFF CTO Server (877626-B21) at 50+ branch locations to host local POS, backup, and edge analytics workloads, integrated with HPE GreenLake hybrid cloud. This edge-to-cloud design slashes WAN traffic by 40%, accelerates inventory restocking insights, and centralizes IT management—achieving a 25% reduction in total cost of ownership and faster branch-level decision making.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table
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| Cooling | Active | Active | Active | Active | Active |
| CPU Socket | LGA 4189 | LGA 4677 | LGA 4189 | LGA 4189 | LGA 4189 |
| Depth | 28 inches | 28 inches | 28 inches | 28 inches | 28.0 inches |
| Drive Bay Size | 3.5-inch | Mixed | 3.5-inch | 3.5-inch | 2.5-inch |
| Form Factor | Rackmount | Rackmount | Rackmount | Rackmount | Rackmount |
| GPU Support | Yes | No | Yes | No | No |
| Height | 3.5 inches | 3.5 inches | 3.44 inches | 3.5 inches | 3.5 inches |
| Hot-Swap Support | Yes | Yes | Yes | Yes | Yes |
| LAN Ports | 4 | 4 | 4 | 2 | 4 |
| Max Cores per CPU | 16 | 16 | 32 | 32 | 32 |
| Max RAM Capacity | 1 TB | 512 GB | 512 GB | 512 GB | 1 TB |
| Max Threads per CPU | 32 | 32 | 64 | 64 | 64 |
| Network Interface | 10GbE | 10GbE | 10GbE | 10GbE | 1GbE |
| Operating System | VMware ESXi | VMware ESXi | Windows Server / VMware ESXi | VMware ESXi | Windows Server |
| PCIe Slots | 4 | 4 | 4 | 4 | 4 |
| PCIe Version | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 |
| Power Supply | Redundant | Redundant | Redundant | Redundant | Redundant |
| Power Supply Wattage | 750W | 800W | 800W | 750W | 800W |
| Processor Brand | Intel | Intel | Intel | Intel | Intel |
| Processor Generation | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen |
| Processor Series | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable |
| Product Name | 877619-001 | 835851-S01 Enterprise Rack Server | P11053-001 Enterprise Server | 765822-001 High Performance Rack Server | 877626-B21 |
| Product Type | Server | Server | Server | Server | Server |
| Rack Units | 2U | 2U | 2U | 2U | 2U |
| RAID Support | RAID 5 | RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 10 | RAID 5 | RAID 0 / RAID 1 / RAID 5 / RAID 10 |
| Rail Kit Included | Yes | Yes | Yes | N/A | Yes |
| RAM Slots | 16 | 8 | 16 | 16 | 16 |
| RAM Type | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 |
| Remote Management | iDRAC | iDRAC | iDRAC | iDRAC | iDRAC |
| Scalability | 2P | 2P | 2P | 2P | 2P |
| Storage Bays | 8 | 8 | 12 | 8 | 8 |
| Storage Type | SATA HDD | Hybrid | Hybrid | SATA SSD | SATA SSD |
| Use Case | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server | Virtualization |
| Virtualization Ready | Yes | Yes | Yes | Yes | Yes |
| Weight | 50 lbs | 45 lbs | 55 lbs | 75 lbs | 45 lbs |
| Width | 17 inches | 19 inches | 19 inches | 19 inches | 17.3 inches |
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Questions & Answers
Q
What are the key features of the HPE ML350 Gen10 SFF CTO Server (SKU: 877626-B21)?
A
The HPE ML350 Gen10 SFF CTO Server features dual Intel Xeon Scalable processors, up to 3 TB DDR4 memory, eight SFF drive bays, HPE iLO 5 management, and modular expandability.
Q
How much memory does the HPE ML350 Gen10 SFF CTO Server support?
A
The HPE ML350 Gen10 SFF CTO supports up to 3 TB of DDR4 ECC memory across 24 DIMM slots for high-performance workloads.
Q
Which processors are compatible with this HPE ML350 Gen10 model?
A
This server is compatible with Intel Xeon Scalable Gold and Platinum processors, up to 28 cores per CPU for intensive compute tasks.
Q
What storage configurations are available in the ML350 Gen10 SFF CTO?
A
The ML350 Gen10 SFF CTO offers eight 2.5″ hot-plug drive bays supporting SAS, SATA, or NVMe SSDs for flexible high-performance storage.
Q
Does the ML350 Gen10 support GPU accelerators?
A
Yes, the server supports up to three single-width or two double-width GPU accelerators via dedicated PCIe slots for AI and parallel compute.
Q
What remote management capabilities does the HPE ML350 Gen10 provide?
A
It includes HPE iLO 5 with Active Health System, OneConfig, RESTful API and Lights-Out remote management for secure, automated administration.
Q
What networking options are available for this server?
A
The ML350 Gen10 SFF CTO comes with four embedded 1 GbE ports and offers optional FlexibleLOM or PCIe network adapters up to 25 GbE.
Q
How energy efficient is the HPE ML350 Gen10 SFF CTO?
A
With HPE Flexible Slot platinum power supplies and advanced thermal design, the ML350 Gen10 reduces energy use and improves performance per watt.
Q
Can I virtualize workloads on the ML350 Gen10?
A
Absolutely. With Intel Virtualization Technology and up to 3 TB memory, the ML350 Gen10 delivers reliable performance for VMware, Hyper-V, and other hypervisors.
Q
What security features are built into the HPE ML350 Gen10?
A
Security features include HPE Silicon Root of Trust, Secure Boot, TPM 2.0, and optional self-encrypting drives for comprehensive server protection.
Q
How scalable is the HPE ML350 Gen10 SFF CTO Server?
A
The ML350 Gen10 offers flexible storage, memory, and PCIe expansion, enabling growth from small businesses to enterprise environments without downtime.
Q
What operating systems are supported on this server?
A
Supported OS options include Microsoft Windows Server, various Linux distributions (RHEL, CentOS, Ubuntu) and VMware ESXi for virtualization.
Q
What warranty and support options are available?
A
HPE offers a standard three-year parts, labor and on-site warranty, with optional HPE Foundation Care and Proactive Care for extended coverage.
Q
How do I configure the ML350 Gen10 SFF CTO Server for high availability?
A
Implement redundant power supplies, mirrored OS drives, RAID storage controllers, and HPE iLO 5 for proactive monitoring to maximize uptime.
Q
What deployment scenarios suit the HPE ML350 Gen10 SFF CTO best?
A
Ideal for SMB file/print, virtualization, database, and edge applications requiring balanced performance, modular expansion, and robust management.