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Solid Xeon Silver processor for everyday Gen10 workloads with stable performance and low power consumption.
866526-L21
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HPE ML350 Gen10 4110 Xeon-S FIO
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866526-L21
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- HPE ML350 Gen10 4110 Xeon-S FIO
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866526-L21 Overview
866526-L21 is a high-performance processor designed for rigorous computing demands. It is an Intel processor from the Intel 13th Gen family featuring the advanced Raptor Lake architecture and a modern LGA 1700 socket. With 16 cores and 24 threads, this CPU achieves a base clock speed of 3.6 GHz and boosts up to 5.0 GHz, while utilizing 16 MB of L2 cache and 30 MB of L3 cache. Its 125W TDP ensures a balanced blend of power and efficiency.
This processor also integrates Intel UHD Graphics 770, operating at a graphics base frequency of 350 MHz and reaching up to 1100 MHz dynamically, making it suitable for both immersive gaming and creative workstation tasks. It supports high-speed memory through DDR4 & DDR5 across dual channels and features PCIe 5.0 connectivity alongside unlocked overclocking options. Overall, the 866526-L21 is built for desktops demanding top-tier performance in gaming, workstation, and general use environments.
866526-L21 price is is available on request. Get immediate quote.
Request bulk order quote for 866526-L21 for additional pricing. Browse the full Hpe Ml350 Server Processors series or explore all Hpe products.
866526-L21 Specifications
- Height
- 0.25
- Width
- 1.5
- ECC Support
- No
- Use Case
- Gaming
- CPU Socket
- LGA 1700
- Memory Channels
- Dual
- PCIe Version
- PCIe 5.0
- Depth
- 1.5
- Product Type
- Processors
- Brand
- Intel
- Virtualization Support
- Intel VT-x
- Cores
- 16
- TDP
- 125W
- Cooler Included
- No
- Series
- Intel Core
- Category
- Desktop
- Max Memory Support
- 128 GB
- Generation
- Intel 13th Gen
- Architecture
- Raptor Lake
- Instruction Set Extensions
- AVX2
- Overclocking Support
- Yes
- Integrated Graphics
- Intel UHD Graphics 770
- Unlocked
- Yes
- Memory Type Support
- DDR4 & DDR5
- Base Clock
- 3.6
- Max Boost Clock
- 5.0
- Graphics Max Dynamic Frequency
- 1100
- Weight
- 0.2
- Graphics Base Frequency
- 350
- Security Features
- SGX
- Threads
- 24
- L2 Cache
- 16
- L3 Cache
- 30
- Product Name
- Intel Core i7-13700K
866526-L21 Use Case
High-Density Virtualization for SMB Infrastructure
In a mid-sized financial services firm running 50+ Windows and Linux virtual machines, the 866526-L21 HPE ML350 Gen10 with Intel Xeon-S 4110 drives consolidation and agility. Its eight-core processor, 192 GB DDR4 memory capacity and scalable NVMe storage enable 3:1 virtualization density. Benefit: 40 % reduction in rack footprint and 30 % lower power costs while maintaining enterprise-grade uptime for critical applications.
Real-Time Edge Analytics in Industrial IoT
A manufacturing plant leverages the 866526-L21 HPE ML350 Gen10 Xeon-S 4110 FIO at the production line edge to ingest and analyze sensor data from 500+ machines. With sub-millisecond I/O latency and hardware-accelerated security (TPM 2.0), it processes predictive maintenance algorithms locally. Benefit: 25 % fewer unplanned outages, 20 % increase in equipment utilization and compliance with industry 4.0 data integrity standards.
Secure On-Premises Backup and Disaster Recovery
A healthcare provider uses the 866526-L21 HPE ML350 Gen10 Xeon-S 4110 FIO as a local backup and DR node for electronic health record (EHR) systems. Configured with HPE StoreEasy storage and HPE iLO 5 remote management, it delivers automated daily snapshots and encrypted replication to an offsite vault. Benefit: 15-minute recovery point objective (RPO), sub-one-hour recovery time objective (RTO), and full HIPAA compliance.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table 
| 866526-L21 |  878660-L21 |  878659-L21 |  878657-L21 |  866538-L21 | |
|---|---|---|---|---|---|
| Product Type | Processors | Processors | Processors | Processors | Processors |
| Brand | Intel | Intel | Intel | Intel | Intel |
| Series | Intel Core | Intel Core | Intel Core | Intel Core | Intel Core |
| Category | Desktop | Desktop | Desktop | Desktop | Desktop |
| Max Memory Support | 128 GB | 128 GB | 128 GB | 128 GB | 128 GB |
| Memory Type Support | DDR4 & DDR5 | DDR4 & DDR5 | DDR5 | DDR5 | DDR4 & DDR5 |
| Generation | Intel 13th Gen | Intel 12th Gen | Intel 13th Gen | Intel 13th Gen | Intel 13th Gen |
| Architecture | Raptor Lake | Alder Lake | Raptor Lake | Raptor Lake | Raptor Lake |
| ECC Support | No | No | No | No | No |
| Security Features | SGX | SGX | None | None | None |
| CPU Socket | LGA 1700 | LGA 1700 | LGA 1700 | LGA 1700 | LGA 1700 |
| Instruction Set Extensions | AVX2 | AVX2 | AVX2 | AVX2 | AVX2 |
| Virtualization Support | Intel VT-x | Intel VT-x | Intel VT-x | Intel VT-x | Intel VT-x |
| Cores | 16 | 8 | 8 | 8 | 8 |
| Threads | 24 | 16 | 16 | 16 | 16 |
| Base Clock | 3.6 | 3.6 GHz | 3.6 | 3.6 | 3.2 GHz |
| Max Boost Clock | 5.0 | 4.9 GHz | 5.0 | 5.0 | 4.8 GHz |
| Overclocking Support | Yes | Yes | Yes | Yes | Yes |
| L2 Cache | 16 | 8 | 4 | 4 | 4 MB |
| L3 Cache | 30 | 16 | 16 | 24 | 16 MB |
| TDP | 125W | 125W | 125W | 125W | 125W |
| Integrated Graphics | Intel UHD Graphics 770 | Intel UHD Graphics 770 | Intel UHD Graphics 770 | Intel UHD Graphics 770 | Intel UHD Graphics 770 |
| Graphics Base Frequency | 350 | 300 MHz | 300 | 350 | 350 MHz |
| Graphics Max Dynamic Frequency | 1100 | 1100 MHz | 1150 | 1100 | 1200 MHz |
| Memory Channels | Dual | Dual | Dual | Dual | Dual |
| PCIe Version | PCIe 5.0 | PCIe 5.0 | PCIe 5.0 | PCIe 5.0 | PCIe 5.0 |
| Unlocked | Yes | Yes | Yes | Yes | Yes |
| Cooler Included | No | No | No | No | No |
| Use Case | Gaming | Gaming | Gaming | Gaming | Gaming |
| Product Name | Intel Core i7-13700K | Intel Core i7-12700K Processor | Intel Core i7-13700K | 878657-L21 | Intel Core i7-13700K |
| Height | 0.25 | N/A | 0.2 inches | 0.5 | N/A |
| Width | 1.5 | N/A | 1.48 inches | 0.5 | N/A |
| Depth | 1.5 | N/A | 1.48 inches | 0.5 | N/A |
| Weight | 0.2 | N/A | 0.3 lbs | 0.3 | N/A |
Reviews & Ratings
A
Arbaz Hussain
4
Runs reliably in production with no performance fluctuations.
S
Stefan Lindholm
4
Installed cleanly and recognized immediately by the system.
P
Paul Redding
5
Good fit for general purpose enterprise servers.
N
Naeem Siddiqui
5
Predictable and dependable CPU choice.
Questions & Answers
What are the key specifications of the HPE ML350 Gen10 4110 Xeon-S FIO (SKU: 866526-L21)?
The HPE ML350 Gen10 4110 Xeon-S FIO (866526-L21) features an Intel Xeon Silver 4110 CPU, up to 1.5 TB DDR4 memory, support for up to 24 SFF or 8 LFF drives, dual 10 GbE ports, HPE iLO 5 management, and redundant hot-plug PSUs.
Which Intel Xeon processor does the HPE ML350 Gen10 866526-L21 use?
The server is equipped with an Intel Xeon Silver 4110 processor, delivering 8 cores, 16 threads, a 2.1 GHz base frequency (up to 3.0 GHz Turbo), and 11 MB of L3 cache for balanced performance.
How much memory can the HPE ML350 Gen10 4110 Xeon-S FIO support?
This system supports up to 1.5 TB of DDR4 SmartMemory across 24 DIMM slots, enabling high-performance workloads and virtualization at enterprise scale.
What storage configurations are available on SKU 866526-L21?
You can configure the ML350 Gen10 with up to eight LFF or 24 SFF hot-plug SAS/SATA drives, plus optional NVMe drive support for high-throughput applications.
Which RAID controller options are compatible with the HPE ML350 Gen10 4110 Xeon-S FIO?
Supported RAID controllers include the HPE Smart Array P408i-m, P408i-p, and HPE Smart SAS H240, delivering hardware RAID levels 0/1/5/6/10/50/60 for data protection.
What network connectivity features does the HPE ML350 Gen10 offer?
Standard networking includes dual 10 GbE 331i adapters, with additional PCIe slots for flexible NIC, Fibre Channel, or 25/40 GbE expansion modules.
What power supply options are available for the HPE ML350 Gen10 866526-L21?
This model supports redundant, hot-plug 500 W, 800 W, or 1600 W Flex Slot power supplies with Platinum efficiency to optimize energy usage and uptime.
How does HPE iLO 5 enhance management on the ML350 Gen10?
HPE iLO 5 provides advanced remote management, automated firmware updates, health monitoring, RESTful API support, and secure remote console access for simplified administration.
Is the HPE ML350 Gen10 4110 Xeon-S FIO suitable for virtualization?
Yes, with support for up to 1.5 TB of memory, multiple CPU cores, and HPE Virtual Connect, it delivers robust performance and scalability for VMware, Hyper-V, and containerized workloads.
What expansion capabilities are available in this server?
The ML350 Gen10 offers seven PCIe Gen3 slots (including three x16 slots), enabling flexible deployment of GPUs, storage controllers, network adapters, and accelerators.
Does the HPE ML350 Gen10 866526-L21 support GPU acceleration?
Yes, it supports up to three half-height, full-length GPUs or accelerators via dedicated PCIe slots for AI, machine learning, and graphics-intensive applications.
Which operating systems are compatible with SKU 866526-L21?
Supported OS options include HPE-tested versions of Microsoft Windows Server, Red Hat Enterprise Linux, SUSE Linux Enterprise Server, Ubuntu Server, and VMware ESXi.
What warranty and support services are available for the HPE ML350 Gen10?
The system includes a 3-year limited warranty with next-business-day replacement, plus optional HPE Foundation Care for enhanced response times and proactive maintenance.
What security features are built into the HPE ML350 Gen10 4110 Xeon-S FIO?
Security features include Silicon Root of Trust, Secure Boot, Secure Recovery, TPM 2.0, and HPE iLO Advanced security controls to protect firmware and data.
What form factor options does the HPE ML350 Gen10 offer?
The ML350 Gen10 is available in a scalable tower form factor with optional rail kit for rack mounting in 4U server cabinets.