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P04653-B21
HPE ProLiant DL325 Gen10 4LFF Configure-to-order Server
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P04653-B21 is a rackmount server built to support Intel Xeon Scalable processors in an LGA 4189 socket, configured for 2P CPU scalability. It is engineered with ECC DDR4 memory supporting up to 1 TB across 16 slots, and features four PCIe expansion slots. The server incorporates eight hot-swappable 3.5-inch storage bays that are compatible with both SATA HDDs and NVMe SSDs, offering RAID 0, RAID 1, RAID 5, and RAID 10 configurations for data protection.
P04653-B21 is equipped with dual 10GbE network interfaces, redundant 800W power supplies, and active cooling for enhanced reliability. Remote management is provided via iDRAC, and the system officially supports operating systems such as VMware ESXi, Windows Server, Ubuntu, and RHEL. This product is purpose-built for data center environments, virtualization platforms, file serving, and application hosting deployments.
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| CPU Socket | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 |
| Cooling | Active | Active | Active | Active | Active |
| Depth | 28 | 28 inches | 28 inches | 28 | 28 inches |
| Drive Bay Size | 3.5-inch | 3.5-inch | 2.5-inch | Mixed | Mixed |
| Form Factor | Rackmount | Rackmount | Rackmount | Rackmount | Rackmount / Tower / Blade / Microserver |
| GPU Support | No | Yes | No | Yes | Yes |
| Height | 3.5 | 3.44 inches | 3.5 inches | 3.5 | 3.5 inches |
| Hot-Swap Support | Yes | Yes | Yes | Yes | Yes |
| LAN Ports | 2 | 4 | 4 | 4 | 4 |
| Max Cores per CPU | 64 | 32 | 32 | 32 | 32 |
| Max RAM Capacity | 1 TB | 1 TB | 1 TB | 1 TB | 512 GB |
| Max Threads per CPU | 128 | 64 | 64 | 64 | 64 |
| Network Interface | 10GbE | 10GbE | 1GbE | 10GbE | 10GbE |
| Operating System | VMware ESXi | Windows Server / VMware ESXi / Ubuntu / RHEL | Windows Server / VMware ESXi / Ubuntu | Windows Server | VMware ESXi |
| PCIe Slots | 4 | 4 | 4 | 4 | 4 |
| PCIe Version | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 |
| Power Supply | Redundant | Redundant | Redundant | Redundant | Redundant |
| Power Supply Wattage | 800W | 750W | 800W | 1000W | 800W |
| Processor Brand | Intel | Intel | Intel | Intel | Intel |
| Processor Generation | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen |
| Processor Series | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable |
| Product Name | P04653-B21 | P04646-B21 High Performance Rack Server | P04654-B21 High Performance Rackmount Server | P04651-AA1 High Performance Rackmount Server | P04662-B21 Enterprise Rack Server |
| Product Type | Server | Server | Server | Server | Server |
| RAID Support | RAID 0, RAID 1, RAID 5, RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 10 | RAID 10 | RAID 10 |
| RAM Slots | 16 | 16 | 16 | 16 | 16 |
| RAM Type | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 |
| Rack Units | 2U | 2U | 2U | 2U | 2U |
| Rail Kit Included | N/A | Yes | Yes | No | Yes |
| Remote Management | iDRAC | iDRAC | iDRAC | iDRAC | iDRAC |
| Scalability | 2P | 2P | 2P | 2P | 2P |
| Storage Bays | 8 | 8 | 8 | 8 | 8 |
| Storage Type | Hybrid | SAS HDD | SATA SSD | SATA SSD | Hybrid |
| Use Case | Virtualization | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server | Virtualization |
| Virtualization Ready | Yes | Yes | Yes | Yes | Yes |
| Weight | 52 | 60 lbs | 45 lbs | 45 | 45 lbs |
| Width | 17 | 19 inches | 17 inches | 17 | 17.5 inches |
CTO configuration gives excellent flexibility.
Stable platform for custom AMD builds.
Good cooling and consistent performance.
Predictable results after deployment.
Solid foundation for scalable setups.
The HPE ProLiant DL325 Gen10 4LFF CTO Server is a 1U rack, single-socket platform powered by AMD EPYC processors, offering four large-form-factor drive bays, HPE iLO 5 management, and flexible I/O to support virtualization, database, and general-purpose workloads.
This server supports AMD EPYC 7002 and 7003 series multi-core processors in a single-socket configuration, delivering up to 64 cores and leading memory bandwidth for compute-intensive applications.
It supports up to 2 TB of DDR4 Smart Memory across eight DIMM slots, operating at speeds up to 3200 MT/s and offering Advanced ECC, Mirroring, and Online Spare for high availability.
The server offers four front-accessible LFF hot-plug bays configurable for SATA, SAS, or optional NVMe SSDs, plus internal M.2 and optional HPE Smart Array controllers for RAID-level data protection.
Yes, the system can be configured with NVMe SSDs in all four LFF bays or via dedicated NVMe backplanes for ultra-low latency storage performance.
It includes flexible LOM options with up to four 1/10/25 GbE ports, plus additional PCIe slots for 25/100 GbE adapters to meet demanding network throughput requirements.
Yes, the server provides a PCIe Gen3 x16 slot that supports select low-profile GPUs for AI inference and compute acceleration in a compact 1U form factor.
Management is handled via HPE iLO 5 with OneView integration, offering secure remote console, firmware updates, scripting, and automated monitoring for maximum uptime.
The server is certified for major enterprise OS platforms including VMware ESXi, Microsoft Windows Server, Red Hat Enterprise Linux, SUSE Linux Enterprise Server, and Ubuntu LTS.
It is validated for VMware vSphere, Microsoft Hyper-V, and Red Hat Virtualization, delivering optimized CPU and memory performance for high VM density.
You can choose redundant 500 W or 800 W Flex Slot power supplies with Platinum efficiency to optimize power draw and maintain high availability.
The 1U chassis measures 43.4 cm in depth, 48.3 cm in width, and 4.3 cm in height, making it suitable for standard rack deployments with 4-inch bezel clearance.
It includes HPE Silicon Root of Trust, TPM 2.0, UEFI Secure Boot, Secure Erase, and optional chassis intrusion detection to protect firmware and data integrity.
This server excels in virtualization, database management, software-defined storage, and high-performance computing workloads where single-socket efficiency and high memory bandwidth are critical.
It comes with a standard 3-year, next-business-day hardware support, with optional HPE Foundation Care, Proactive Care, and mission-critical support service packages.
Use the HPE Configure-to-Order online tool or partner portal to select CPUs, memory, storage, networking, management, and support options tailored to your workload requirements.