United States$5,000,000+
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Omar Kensington
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Performance oriented Gen10 server handles demanding tasks well.
P06420-B21
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HPE ProLiant DL380 Gen10 4110 2.1GHz 8-core 1P 16GB-R P408i-...
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P06420-B21
- Description:
- HPE ProLiant DL380 Gen10 4110 2.1GHz 8-core 1P 16GB-R P408i-a 8SFF 500W PS Performance Server
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P06420-B21 Overview
P06420-B21 is a high-performance rackmount server engineered to support Intel Xeon Scalable processors of the 3rd Gen series with an LGA 4189 socket, enabling a dual-processor (2P) configuration that delivers robust computing power. It comes equipped with ECC DDR4 memory supporting up to 1 TB across 16 slots, along with 4 PCIe expansion slots and 8 hot-swap 2.5-inch storage bays featuring RAID 10 support and a 10GbE network interface with 2 LAN ports.
Optimized for demanding environments, this server includes redundant 1000W power supplies and active cooling to ensure reliable operation, complemented by integrated iDRAC remote management for streamlined maintenance. Its compatibility with operating systems such as Windows Server makes it an ideal solution for data center deployments, virtualization, file serving, and application server use cases.
P06420-B21 price is is available on request. Get immediate quote.
Request bulk order quote for P06420-B21 for additional pricing. Browse the full Hpe Proliant Dl380 Gen10 Servers series or explore all Hpe products.
P06420-B21 Specifications
- Product Type
- Server
- Form Factor
- Rackmount
- Rack Units
- 2U
- Processor Brand
- Intel
- Processor Series
- Intel Xeon Scalable
- Processor Generation
- Xeon 3rd Gen
- Use Case
- Application Server
- CPU Socket
- LGA 4189
- Scalability
- 2P
- Max Cores per CPU
- 16
- Max Threads per CPU
- 32
- RAM Type
- ECC DDR4
- RAM Slots
- 16
- Max RAM Capacity
- 1 TB
- Storage Type
- NVMe SSD
- Storage Bays
- 8
- Drive Bay Size
- 2.5-inch
- Hot-Swap Support
- Yes
- RAID Support
- RAID 10
- PCIe Slots
- 4
- PCIe Version
- PCIe 4.0
- Network Interface
- 10GbE
- LAN Ports
- 2
- Remote Management
- iDRAC
- Power Supply
- Redundant
- Power Supply Wattage
- 1000W
- Cooling
- Active
- Operating System
- Windows Server
- Virtualization Ready
- Yes
- GPU Support
- No
- Rail Kit Included
- Yes
- Product Name
- P06420-B21
- Height
- 3.5 inches
- Width
- 17.3 inches
- Depth
- 28.7 inches
- Weight
- 60 lbs
P06420-B21 Use Case
Virtualization Infrastructure Optimization with P06420-B21 HPE ProLiant DL380 Gen10
A mid-sized enterprise implements the P06420-B21 HPE ProLiant DL380 Gen10 4110 2.1GHz 8-core Performance Server to consolidate 20+ VMware vSphere virtual machines for ERP, CRM and file services. Leveraging 16 GB RAM and the HPE P408i-a RAID controller with eight SFF bays, the deployment achieves 40% faster VM provisioning, 30% higher I/O throughput and 99.99% service availability—streamlining management, reducing rack footprint and cutting TCO.
Accelerated SQL Server Transaction Processing on P06420-B21 HPE ProLiant DL380 Gen10
A financial services firm uses the P06420-B21 HPE ProLiant DL380 Gen10 4110 8-core server to host mission-critical Microsoft SQL Server databases handling 10,000+ daily transactions. With optimized RAID-5 on the P408i-a controller and tiered flash storage, query latency drops by 25% while throughput scales 2× under peak load. The result is sub-second response times, improved customer experience and predictable transaction performance.
Edge Analytics for Manufacturing IoT with P06420-B21 HPE ProLiant DL380 Gen10
A global manufacturer deploys the P06420-B21 HPE ProLiant DL380 Gen10 4110 Performance Server at a smart-factory edge node to process real-time sensor data from 500+ machines. Equipped with 16 GB RAM and high-performance RAID, the server delivers sub-10 ms analytics, reduces WAN backhaul by 60% and supports predictive maintenance algorithms. The outcome is minimized downtime, lower bandwidth costs and rapid on-site decision-making.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table 
| P06420-B21 |  P02462-B21 |  P19719-B21 |  P06421-B21 |  826567-B21 | |
|---|---|---|---|---|---|
| CPU Socket | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 |
| Cooling | Active | Active | Active | Active | Active |
| Depth | 28.7 inches | 28.0 inches | 28.0 inches | 28 inches | 28.5 inches |
| Drive Bay Size | 2.5-inch | 2.5-inch | 3.5-inch | 3.5-inch | 3.5-inch |
| Form Factor | Rackmount | Rackmount | Rackmount | Rackmount | Rackmount |
| GPU Support | No | No | No | Yes | Yes |
| Height | 3.5 inches | 3.5 inches | 3.5 inches | 3.5 inches | 3.5 inches |
| Hot-Swap Support | Yes | Yes | Yes | Yes | Yes |
| LAN Ports | 2 | 4 | 4 | 2 | 4 |
| Max Cores per CPU | 16 | 32 | 32 | 32 | 32 |
| Max RAM Capacity | 1 TB | 1 TB | 512 GB | 2 TB | 512 GB |
| Max Threads per CPU | 32 | 64 | 64 | 64 | 64 |
| Network Interface | 10GbE | 10GbE | 10GbE | 10GbE | 10GbE |
| Operating System | Windows Server | Windows Server | Windows Server | Windows Server / VMware ESXi / Ubuntu | VMware ESXi |
| PCIe Slots | 4 | 4 | 4 | 6 | 4 |
| PCIe Version | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 |
| Power Supply | Redundant | Redundant | Redundant | Redundant | Redundant |
| Power Supply Wattage | 1000W | 750W | 1200W | 1000W | 1000W |
| Processor Brand | Intel | Intel | Intel | Intel | Intel |
| Processor Generation | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 4th Gen |
| Processor Series | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable |
| Product Name | P06420-B21 | P02462-B21 Enterprise Rack Server | P19719-B21 Enterprise Rackmount Server | P06421-B21 | 826567-B21 Server |
| Product Type | Server | Server | Server | Server | Server |
| RAID Support | RAID 10 | RAID 5 | RAID 0 / RAID 1 / RAID 5 / RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10 | RAID 10 |
| RAM Slots | 16 | 16 | 16 | 16 | 16 |
| RAM Type | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR5 | ECC DDR4 |
| Rack Units | 2U | 2U | 2U | 2U | 2U |
| Rail Kit Included | Yes | No | N/A | No | Yes |
| Remote Management | iDRAC | iDRAC | iDRAC | iDRAC | iDRAC |
| Scalability | 2P | 2P | 2P | 2P | 2P |
| Storage Bays | 8 | 12 | 8 | 8 | 8 |
| Storage Type | NVMe SSD | SATA SSD | SAS HDD | SATA SSD | SATA SSD |
| Use Case | Application Server | Virtualization / File Server / Application Server | Virtualization | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server |
| Virtualization Ready | Yes | Yes | Yes | Yes | Yes |
| Weight | 60 lbs | 45 lbs | 40 lbs | 45 lbs | 45 lbs |
| Width | 17.3 inches | 17.5 inches | 17.5 inches | 17.5 inches | 17.5 inches |
Reviews & Ratings
S
Sajjad Khan
4
Stable under continuous compute load.
J
Jonas Richter
5
Good balance of power and efficiency.
H
Henry Walsham
5
Reliable rack server for enterprise use.
R
Rehan Akbar
4
Consistent production performance.
Questions & Answers
What are the key specifications of the HPE ProLiant DL380 Gen10 4110 2.1GHz 8-core 1P 16GB-R P408i-a 8SFF 500W PS Performance Server?
The server features an Intel Xeon Silver 4110 2.1GHz 8-core CPU, 16GB DDR4 RAM, HPE Smart Array P408i-a RAID controller, eight SFF drive bays and a 500W redundant power supply.
How many processor cores does the HPE DL380 Gen10 4110 server support?
It supports a single Intel Xeon Silver 4110 processor with 8 physical cores, enabling multi-threaded workloads and virtualization.
What memory configuration comes standard with this HPE ProLiant DL380 Gen10 server?
It ships with 16GB of DDR4 Registered Memory, expandable up to 3TB across 24 DIMM slots for high-density applications.
What storage options are available with the HPE Smart Array P408i-a and eight SFF bays?
You can install up to eight small form factor SAS or SATA drives, supporting NVMe via optional risers for up to 24 drives.
Is the 500W power supply on this server redundant?
Yes. It includes a 500W hot-plug, high-efficiency power supply with N+1 redundancy options for continuous uptime.
What performance benefits does the Intel Xeon Silver 4110 2.1GHz CPU deliver?
The Xeon Silver 4110 offers 8 cores, 16 threads, Turbo Boost to 3.0GHz and 11MB cache, delivering balanced compute for virtualization and database tasks.
How can I expand storage capacity on the DL380 Gen10 Performance Server?
Add HPE Flexible Smart Array controllers, NVMe drive risers or upgrade to larger SFF/SAS drives. Up to 24 small form factor drives are supported.
What integrated management tools are included with this server?
It includes HPE iLO 5 for remote management, HPE OneView integration, Active Health System and Intelligent Provisioning for simplified deployment.
Is the DL380 Gen10 compatible with HPE OneView for infrastructure automation?
Yes. The server fully supports HPE OneView, enabling API-driven automation, firmware management and firmware compliance.
What security features does the HPE ProLiant DL380 Gen10 offer?
It offers Silicon Root of Trust, secure boot, runtime firmware validation and TPM 2.0 to protect firmware and data integrity.
Which operating systems are supported on the DL380 Gen10 4110 8-core server?
Supported OSes include Windows Server, Red Hat Enterprise Linux, SUSE Linux Enterprise Server and VMware ESXi.
What are the ideal use cases for the HPE DL380 Gen10 Performance Server?
Use cases include virtualization, database workloads, high-performance computing, cloud infrastructure and enterprise applications.
How energy-efficient is the HPE DL380 Gen10 with a 500W power supply?
It meets 80 PLUS Platinum efficiency, reducing power consumption by up to 94% under typical loads.
Can I upgrade memory and processors in the future?
Yes. It supports future CPU upgrades up to 28 cores per socket and memory upgrades up to 3TB using HPE DDR4 SmartMemory.
What warranty and support options are available for this server?
Standard HPE 3-year Parts, Labor and Onsite support is included, with options to extend to 5 years or add 24x7 coverage.
How does the DL380 Gen10 ensure high availability in a data center environment?
It offers redundant power supplies, hot-plug drives, Smart Array RAID, iLO remote management and HPE InfoSight predictive analytics.