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Performance focused Gen10 server handles demanding tasks efficiently.
P06422-B21
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HPE ProLiant DL380 Gen10 5118 2.3GHz 12-core 1P 64GB-R P408i...
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P06422-B21
- Description:
- HPE ProLiant DL380 Gen10 5118 2.3GHz 12-core 1P 64GB-R P408i-a 8SFF 800W RPS Performance Server
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P06422-B21 Overview
P06422-B21 is a rackmount server featuring Intel Xeon Scalable 3rd Gen processors with LGA 4189 socket support and 2P CPU scalability, delivering up to 32 cores and 64 threads per processor. It supports ECC DDR4 memory with a capacity up to 2 TB installed in 16 slots, offers 4 PCIe 4.0 expansion slots, and provides 8 storage bays designed for 2.5-inch drives with RAID 1 support alongside 4 x 10GbE network interfaces, redundant 1200W power supplies, active cooling, and iDRAC remote management compatible with VMware ESXi.
P06422-B21 is optimized for data center environments, virtualization tasks, file serving, and application server workloads, ensuring robust performance and efficient remote management for enterprise-level operations.
P06422-B21 price is is available on request. Get immediate quote.
Request bulk order quote for P06422-B21 for additional pricing. Browse the full Hpe Proliant Dl380 Gen10 Servers series or explore all Hpe products.
P06422-B21 Specifications
- Product Type
- Server
- Form Factor
- Rackmount
- Rack Units
- 2U
- Processor Brand
- Intel
- Processor Series
- Intel Xeon Scalable
- Processor Generation
- Xeon 3rd Gen
- Use Case
- Virtualization
- CPU Socket
- LGA 4189
- Scalability
- 2P
- Max Cores per CPU
- 32
- Max Threads per CPU
- 64
- RAM Type
- ECC DDR4
- RAM Slots
- 16
- Max RAM Capacity
- 2 TB
- Storage Type
- SATA SSD
- Storage Bays
- 8
- Drive Bay Size
- 2.5-inch
- Hot-Swap Support
- Yes
- RAID Support
- RAID 1
- PCIe Slots
- 4
- PCIe Version
- PCIe 4.0
- Network Interface
- 10GbE
- LAN Ports
- 4
- Remote Management
- iDRAC
- Power Supply
- Redundant
- Power Supply Wattage
- 1200W
- Cooling
- Active
- Operating System
- VMware ESXi
- Virtualization Ready
- Yes
- GPU Support
- Yes
- Rail Kit Included
- Yes
- Product Name
- P06422-B21
- Height
- 3.5 inches
- Width
- 17.0 inches
- Depth
- 28.0 inches
- Weight
- 35 lbs
P06422-B21 Use Case
Virtualized Multi-Tier Application Consolidation
A mid-market IT department deploys the P06422-B21 HPE ProLiant DL380 Gen10 (5118 2.3 GHz, 12-core, 1P, 64 GB-R, P408i-a, 8SFF, 800 W RPS) as the core host for VMware ESXi, consolidating 50+ Windows and Linux VMs. The server’s 12-core processor, 64 GB memory footprint and eight SFF drive bays deliver high VM density, predictable I/O performance and sub-millisecond storage latency. Outcome: 60% reduction in hardware footprint, 40% lower power/cooling costs and 99.99% VM uptime.
Real-Time Big Data Analytics and Machine Learning
A financial services firm leverages the HPE ProLiant DL380 Gen10 5118 platform to run Apache Spark and Hadoop workloads for real-time fraud detection. The P06422-B21’s multi-threaded 12-core CPU, hardware RAID 1/10 via the P408i-a controller and redundant 800 W power supplies ensure sustained throughput and zero single-point failures. Outcome: 5× faster batch processing, sub-second query response times and improved risk-management insights.
Mission-Critical SQL Database Hosting
An e-commerce provider uses the DL380 Gen10 (P06422-B21) to host high-transaction Microsoft SQL Server and Oracle databases. Eight hot-swap SFF drives configured in RAID 10 and the enterprise-grade P408i-a cache accelerator deliver >100,000 IOPS under load. Outcome: 35% lower transaction latency, 99.995% database availability and streamlined maintenance with HPE iLO 5 remote management.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table 
| P06422-B21 |  848774-B21 |  767032-B21 |  P06421-B21 |  752686-B21 | |
|---|---|---|---|---|---|
| CPU Socket | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 |
| Cooling | Active | Active | Active | Active | Active |
| Depth | 28.0 inches | 30 inches | 28 inches | 28 inches | 28 inches |
| Drive Bay Size | 2.5-inch | 2.5-inch | 2.5-inch | 3.5-inch | 3.5-inch |
| Form Factor | Rackmount | Rackmount | Rackmount | Rackmount | Rackmount |
| GPU Support | Yes | Yes | Yes | Yes | No |
| Height | 3.5 inches | 1.75 inches | 3.5 inches | 3.5 inches | 7 inches |
| Hot-Swap Support | Yes | Yes | Yes | Yes | Yes |
| LAN Ports | 4 | 4 | 4 | 2 | 4 |
| Max Cores per CPU | 32 | 32 | 32 | 32 | 32 |
| Max RAM Capacity | 2 TB | 1 TB | 2 TB | 2 TB | 1 TB |
| Max Threads per CPU | 64 | 64 | 64 | 64 | 64 |
| Network Interface | 10GbE | 10GbE | 1GbE | 10GbE | 1GbE |
| Operating System | VMware ESXi | Windows Server / VMware ESXi / Ubuntu | Windows Server | Windows Server / VMware ESXi / Ubuntu | VMware ESXi |
| PCIe Slots | 4 | 4 | 4 | 6 | 6 |
| PCIe Version | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 |
| Power Supply | Redundant | Redundant | Redundant | Redundant | Redundant |
| Power Supply Wattage | 1200W | 750W | 750W | 1000W | 750W |
| Processor Brand | Intel | Intel | Intel | Intel | Intel |
| Processor Generation | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen |
| Processor Series | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable |
| Product Name | P06422-B21 | 848774-B21 | 767032-B21 Server | P06421-B21 | 752686-B21 |
| Product Type | Server | Server | Server | Server | Server |
| RAID Support | RAID 1 | RAID 1 / RAID 5 / RAID 10 | RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10 | RAID 0 / RAID 1 / RAID 10 |
| RAM Slots | 16 | 16 | 16 | 16 | 16 |
| RAM Type | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR5 | ECC DDR4 |
| Rack Units | 2U | 1U | 2U | 2U | 2U |
| Rail Kit Included | Yes | Yes | N/A | No | No |
| Remote Management | iDRAC | iDRAC | iDRAC | iDRAC | iDRAC |
| Scalability | 2P | 2P | 2P | 2P | 2P |
| Storage Bays | 8 | 8 | 8 | 8 | 8 |
| Storage Type | SATA SSD | SATA SSD | NVMe SSD | SATA SSD | SATA HDD |
| Use Case | Virtualization | Virtualization / File Server / Application Server | Virtualization | Virtualization / File Server / Application Server | Virtualization |
| Virtualization Ready | Yes | Yes | Yes | Yes | Yes |
| Weight | 35 lbs | 50 lbs | 50 lbs | 45 lbs | 45 lbs |
| Width | 17.0 inches | 19 inches | 17 inches | 17.5 inches | 19 inches |
Reviews & Ratings
R
Rameez Ahmed
5
Stable under continuous compute load.
J
Jonas Lindholm
5
Good balance of power and efficiency.
M
Matthew Rourke
4
Reliable rack server for enterprise use.
B
Bilal Farooq
4
Consistent production performance.
Questions & Answers
What processor powers the HPE ProLiant DL380 Gen10 P06422-B21 server?
The server is equipped with a single Intel Xeon Silver 5118 processor running at 2.3 GHz and providing 12 cores for balanced compute performance.
How much memory does the HPE ProLiant DL380 Gen10 P06422-B21 include?
It ships with 64 GB of DDR4 Registered (RDIMM) memory, supporting speeds up to 2666 MT/s and expandable up to 3 TB.
What storage configuration is supported by this server?
The system supports eight Small Form Factor (SFF) drive bays and includes the HPE Smart Array P408i-a RAID controller for RAID 0/1/5/6/10/50/60 configurations.
Which RAID levels are available on the Smart Array P408i-a controller?
The P408i-a supports RAID 0, 1, 5, 6, 10, 50, and 60, delivering versatile data protection and performance tuning options.
What power supply does the HPE ProLiant DL380 Gen10 P06422-B21 use?
It includes an 800 W hot-plug, redundant power supply (RPS) with up to 94% efficiency, ensuring continuous uptime and reduced energy costs.
What remote management features are available?
HPE Integrated Lights-Out (iLO 5) offers remote console, power management, firmware updates, and health monitoring via a secure web interface or API.
What are the form factor and rack requirements for this server?
The ProLiant DL380 Gen10 is a 2U rack-mount server compatible with standard 19-inch racks and sliding rail kits for easy installation.
Can I expand memory and storage in the future?
Yes, the system supports up to 24 DDR4 DIMM slots and additional storage via optional M.2 or PCIe NVMe drives and Smart Array controllers.
Which network interfaces are included by default?
This model features four integrated 1 GbE Ethernet ports, with optional FlexibleLOM or PCIe network adapters for higher throughput up to 10/25/100 GbE.
Is the HPE ProLiant DL380 Gen10 suitable for virtualization?
Absolutely. With its 12-core CPU, large memory capacity, and VMware, Hyper-V, and KVM compatibility, it delivers robust virtualization performance.
Which operating systems are supported on this server?
It supports a broad range of OS including Microsoft Windows Server, Red Hat Enterprise Linux, SUSE Linux Enterprise Server, and VMware ESXi.
What workloads is the DL380 Gen10 optimized for?
It excels in database management, virtualization, high-performance computing, and cloud-native applications requiring balanced CPU, memory, and storage.
Does this server offer security features to protect data?
Yes, it includes HPE Secure Boot, Runtime Firmware Validation, Silicon Root of Trust, and TPM 2.0 to safeguard firmware and data integrity.
How energy efficient is the HPE ProLiant DL380 Gen10?
With 94% efficient power supplies, advanced cooling, and Intelligent System Tuning, it minimizes energy consumption while maximizing performance.
What warranty and support options are available?
The system comes with a standard 3-year HPE ProLiant warranty, with optional Care Pack services for 24x7 support, parts replacement, and proactive updates.
How does HPE OneView integration benefit server management?
HPE OneView provides unified infrastructure management—including provisioning, monitoring, and firmware updates—via a single pane of glass.