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P00375-B21
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HPE 2048GB NVME X4 RI M.2 2280
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Hand-picked by our procurement team for standout value. This unit is offered at our sharpest price on current stock, verified against live market rates.
Name:
P00375-B21
- Description:
- HPE 2048GB NVME X4 RI M.2 2280
- Rating:
Added to cart 28 times recently
- Availability:
2 In stock - Ready to Ship
- Brand:
- Hpe
- Condition:
Certified Refurbished
Professionally inspected, bench-tested, and firmware-verified, with configurations wiped. Restored to full working order and backed by our warranty.
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P00375-B21 Overview
P00375-B21 is a high-performance HDD engineered in a 3.5-inch form factor and built for demanding enterprise environments. It features a SAS 12Gb/s interface, a 7200 RPM spindle speed, a robust 10 TB storage capacity, and a substantial 256 MB cache while relying on a proven design to handle mission‐critical applications.
Optimized for server, desktop, NAS, surveillance, and enterprise storage use cases, this drive is rated for an annual workload of 550 TB/yr and is designed for exceptional reliability. With low power consumption (8 Watts under read/write and 5 Watts idle), advanced helium-sealed construction, integrated vibration protection, and a dual actuator feature, P00375-B21 is suited for multi‐bay deployments in data centers and other high‐demand environments.
P00375-B21 price is is available on request. Get immediate quote.
Request bulk order quote for P00375-B21 for additional pricing. Browse the full Hpe Server M.2&Pcie Hard Drives series or explore all Hpe products.
P00375-B21 Specifications
- Product Type
- Hard Drive
- Brand
- Hpe
- Drive Type
- HDD
- Use Case
- Desktop / Server / NAS / Surveillance / Enterprise Storage
- Interface
- SAS 12Gb/s
- Form Factor
- 3.5-inch
- Storage Capacity
- 10 TB
- Spindle Speed (RPM)
- 7200 RPM
- Cache (Buffer Size)
- 256 MB
- Data Transfer Rate
- Up to 250 MB/s
- Annual Workload Rating
- 550 TB/yr
- Power Consumption (Read/Write)
- 8 Watts
- Power Consumption (Idle)
- 5 Watts
- Encryption Support
- AES 256-bit
- Helium Sealed
- Helium-Sealed
- Drive Bays Supported
- Multi-bay
- Vibration Protection
- Yes
- Advanced Features
- Dual Actuator
- Operating Temperature
- 5–60°C
- Product Name
- P00375-B21
- Height
- 1.03 inches
- Width
- 5.79 inches
- Depth
- 4.00 inches
- Weight
- 1.55 lbs
P00375-B21 Use Case
Real-Time Financial Trading Acceleration with P00375-B21-HPE 2048GB NVMe X4 RI M.2 2280
In a global investment bank’s low-latency order matching cluster, deploying the P00375-B21-HPE 2048GB NVMe X4 RI M.2 2280 module on HPE ProLiant servers delivers sub-microsecond I/O response. This use case drives a 40% uplift in transaction throughput, ensures consistent order book updates, and safeguards competitive advantage in high-frequency trading environments.
Enterprise VDI Boot Storm Mitigation with P00375-B21-HPE 2048GB NVMe X4 RI M.2 2280
A Fortune 500 corporation integrates P00375-B21-HPE 2048GB NVMe X4 RI M.2 2280 SSDs as boot volumes for 2,500 concurrent Virtual Desktop Infrastructure (VDI) instances. Resulting in 60% faster login times, near-instant desktop provisioning, and a 35% reduction in help-desk tickets, this solution optimizes end-user experience and maximizes IT resource utilization.
Edge AI Inference Acceleration with P00375-B21-HPE 2048GB NVMe X4 RI M.2 2280
A telecommunications provider deploys P00375-B21-HPE 2048GB NVMe X4 RI M.2 2280 drives in edge compute nodes to cache preprocessed sensor data for real-time AI inference. By halving data-load latency and boosting model throughput by 30%, this implementation reduces WAN backhaul, accelerates decision-making at the network edge, and supports scalable IoT analytics.
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Product Comparison Table 
| P00375-B21 |  875581-B21 |  880264-B21 |  880266-B21 |  877829-B21 | |
|---|---|---|---|---|---|
| Product Type | Hard Drive | Hard Drive | Hard Drive | Hard Drive | Hard Drive |
| Drive Type | HDD | HDD | HDD | HDD | HDD |
| Use Case | Desktop / Server / NAS / Surveillance / Enterprise Storage | Desktop / Server / NAS / Surveillance / Enterprise Storage | Desktop / Server / NAS / Surveillance / Enterprise Storage | Server / Enterprise Storage | Desktop / Server / NAS / Surveillance / Enterprise Storage |
| Interface | SAS 12Gb/s | SATA III | SATA III | SATA III | SATA III |
| Form Factor | 3.5-inch | 3.5-inch | 3.5-inch | 3.5-inch | 3.5-inch |
| Storage Capacity | 10 TB | 8 TB | 4 TB | 8 TB | 4 TB |
| Spindle Speed (RPM) | 7200 RPM | 7200 RPM | 7200 RPM | 7200 RPM | 7200 RPM |
| Cache (Buffer Size) | 256 MB | 256 MB | 128 MB | 256 MB | 128 MB |
| Data Transfer Rate | Up to 250 MB/s | Up to 250 MB/s | Up to 250 MB/s | Up to 250 MB/s | Up to 250 MB/s |
| Annual Workload Rating | 550 TB/yr | 180 TB/yr | 180 TB/yr | 550 TB/yr | 300 TB/yr |
| Power Consumption (Read/Write) | 8 Watts | 7 Watts | 8.0 Watts | 8 Watts | 8.5 Watts |
| Power Consumption (Idle) | 5 Watts | 4 Watts | 6.0 Watts | 5 Watts | 4.5 Watts |
| Encryption Support | AES 256-bit | AES 256-bit | AES 256-bit | AES 256-bit | AES 256-bit |
| Helium Sealed | Helium-Sealed | Helium-Sealed | Helium-Sealed | Helium-Sealed | Helium-Sealed |
| Drive Bays Supported | Multi-bay | Multi-bay | Multi-bay | Multi-bay | Multi-bay |
| Vibration Protection | Yes | Yes | Yes | Yes | Yes |
| Advanced Features | Dual Actuator | Dual Actuator | Rotational Vibration Sensors | Dual Actuator | Dual Actuator |
| Operating Temperature | 5–60°C | 5–60°C | 5–60°C | 5–60°C | 5–60°C |
| Product Name | P00375-B21 | 875581-B21 | 880264-B21 Enterprise 4TB SATA HDD | Seagate Exos X18 8TB 7200 RPM SATA III Enterprise HDD | 877829-B21 Enterprise Helium-Sealed HDD |
| Height | 1.03 inches | 1.03 inches | 1.03 inches | 1.0 inches | 1 inches |
| Width | 5.79 inches | 5.79 inches | 5.75 inches | 5.8 inches | 5.8 inches |
| Depth | 4.00 inches | 4 inches | 4.02 inches | 4.0 inches | 4 inches |
| Weight | 1.55 lbs | 2.2 lbs | 1.55 lbs | 1.8 lbs | 1.5 lbs |
Compliance & Warranty
100% Genuine Product Guarantee
Every unit is authentic, sourced through trusted and authorised channels, and serial-verified on request. Genuine networking and IT hardware, guaranteed, or your money back.
Up to 3-Year Warranty Coverage
New products are backed by up to 3 years of extended warranty, and certified refurbished units by up to 3 months, for dependable protection on every order. Coverage is clear, honoured in full, and confirmed on each product page.
Hassle-Free RMA & Returns
If a unit ever falls short, our streamlined RMA process gets a replacement to you fast, with advance replacement available to keep your network running. No jargon, no runaround.
Rigorously Tested & Quality Assured
Every device is inspected, bench-tested, and firmware-verified, with configurations wiped before dispatch. Additional testing can be arranged to confirm full working condition on request.
Expert Technical Support
Our specialists assist with compatibility, configuration, licensing, and installation, before and after you buy. Real hardware expertise, whenever you need it.
Fast Global Delivery
dispatched quickly and shipped worldwide from regional hubs, fully tracked and insured.
Reviews & Ratings
C
Colin Matthews
4
2TB NVMe M.2 handled read-intensive workloads reliably.
A
Arif Hussain
5
Consistent throughput and low latency.
D
Daniel Kim
4
OEM quality storage.
W
Waleed Khan
4
Good for enterprise caching.
R
Rasmus Lind
5
Strong performance.
Questions & Answers
What is the storage capacity of the HPE P00375-B21 NVMe SSD?
The HPE P00375-B21 NVMe SSD delivers 2048 GB of usable storage capacity in an M.2 2280 form factor.
Which interface and PCIe lanes does the HPE 2048GB NVMe X4 RI M.2 2280 use?
It uses the NVMe 1.4 protocol over a PCIe Gen4 x4 interface to maximize throughput and minimize latency.
What are the sequential read and write performance specifications?
The drive achieves up to 7,000 MB/s sequential reads and up to 5,100 MB/s sequential writes under optimal conditions.
What random IOPS can I expect from this HPE NVMe SSD?
It delivers up to 1.2 million random read IOPS and up to 300,000 random write IOPS at QD32.
What workload profile is the HPE P00375-B21 optimized for?
This SSD is engineered for read-intensive (RI) data-center workloads such as boot, caching, database reads, and analytics.
What endurance rating does the HPE 2048GB NVMe X4 RI drive have?
It is rated for 1 Drive Write per Day (DWPD) over a 5-year service life and supports up to 3,650 TB written.
Is the HPE P00375-B21 hot-swappable in HPE servers?
Yes, it supports hot-swap operation in all HPE Gen10 and Gen11 servers with an M.2 rear-I/O slot and NVMe backplane.
Which HPE server platforms are compatible with this M.2 SSD?
It is compatible with HPE ProLiant Gen10+ and Gen11 series servers featuring an M.2 2280 NVMe connector and appropriate BIOS support.
Does the HPE 2048GB NVMe X4 RI offer built-in data encryption?
Yes, it supports AES-256 hardware encryption and TCG Pyrite compliance for secure data-at-rest protection.
What management tools are available for monitoring this NVMe SSD?
You can monitor health, performance, and firmware updates using HPE Smart Storage Administrator and standard NVMe-CLI utilities.
What are the operating temperature and shock tolerances?
The SSD operates from 0 °C to 70 °C, survives 1,500 G shock, and endures 20 G rms vibration between 10–2,000 Hz.
What is the mean time between failures (MTBF) for this drive?
The HPE P00375-B21 NVMe SSD has an MTBF rating of 2 million hours.
How do I install the HPE M.2 2280 NVMe SSD in my server?
Simply insert the drive into the M.2 2280 slot at a 30° angle, press down, secure it with the mounting screw, and enable NVMe support in BIOS.
What power consumption should I plan for?
Typical active power is 6.5 W, with a maximum of 8 W during peak writes and under 50 mW in idle mode.
What warranty coverage does the HPE 2048GB NVMe X4 RI include?
HPE provides a standard 5-year limited warranty with proactive notification of drive failures via HPE InfoSight.