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Colin Matthews
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2TB NVMe M.2 handled read-intensive workloads reliably.
P00375-B21
HPE 2048GB NVME X4 RI M.2 2280
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P00375-B21
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- HPE 2048GB NVME X4 RI M.2 2280
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P00375-B21 Overview
P00375-B21 is a high-performance HDD engineered in a 3.5-inch form factor and built for demanding enterprise environments. It features a SAS 12Gb/s interface, a 7200 RPM spindle speed, a robust 10 TB storage capacity, and a substantial 256 MB cache while relying on a proven design to handle mission‐critical applications.
Optimized for server, desktop, NAS, surveillance, and enterprise storage use cases, this drive is rated for an annual workload of 550 TB/yr and is designed for exceptional reliability. With low power consumption (8 Watts under read/write and 5 Watts idle), advanced helium-sealed construction, integrated vibration protection, and a dual actuator feature, P00375-B21 is suited for multi‐bay deployments in data centers and other high‐demand environments.
P00375-B21 price is is available on request. Get immediate quote.
Request bulk order quote for P00375-B21 for additional pricing. Browse the full Hpe Server M.2&Pcie Hard Drives series or explore all Hpe products.
P00375-B21 Specifications
- Product Type
- Hard Drive
- Drive Type
- HDD
- Use Case
- Desktop / Server / NAS / Surveillance / Enterprise Storage
- Interface
- SAS 12Gb/s
- Form Factor
- 3.5-inch
- Storage Capacity
- 10 TB
- Spindle Speed (RPM)
- 7200 RPM
- Cache (Buffer Size)
- 256 MB
- Average Latency
- N/A
- Data Transfer Rate
- Up to 250 MB/s
- Annual Workload Rating
- 550 TB/yr
- Power Consumption (Read/Write)
- 8 Watts
- Power Consumption (Idle)
- 5 Watts
- Encryption Support
- AES 256-bit
- Helium Sealed
- Helium-Sealed
- Drive Bays Supported
- Multi-bay
- Vibration Protection
- Yes
- Advanced Features
- Dual Actuator
- Operating Temperature
- 5–60°C
- Product Name
- P00375-B21
- Height
- 1.03 inches
- Width
- 5.79 inches
- Depth
- 4.00 inches
- Weight
- 1.55 lbs
P00375-B21 Use Case
Real-Time Financial Trading Acceleration with P00375-B21-HPE 2048GB NVMe X4 RI M.2 2280
In a global investment bank’s low-latency order matching cluster, deploying the P00375-B21-HPE 2048GB NVMe X4 RI M.2 2280 module on HPE ProLiant servers delivers sub-microsecond I/O response. This use case drives a 40% uplift in transaction throughput, ensures consistent order book updates, and safeguards competitive advantage in high-frequency trading environments.
Enterprise VDI Boot Storm Mitigation with P00375-B21-HPE 2048GB NVMe X4 RI M.2 2280
A Fortune 500 corporation integrates P00375-B21-HPE 2048GB NVMe X4 RI M.2 2280 SSDs as boot volumes for 2,500 concurrent Virtual Desktop Infrastructure (VDI) instances. Resulting in 60% faster login times, near-instant desktop provisioning, and a 35% reduction in help-desk tickets, this solution optimizes end-user experience and maximizes IT resource utilization.
Edge AI Inference Acceleration with P00375-B21-HPE 2048GB NVMe X4 RI M.2 2280
A telecommunications provider deploys P00375-B21-HPE 2048GB NVMe X4 RI M.2 2280 drives in edge compute nodes to cache preprocessed sensor data for real-time AI inference. By halving data-load latency and boosting model throughput by 30%, this implementation reduces WAN backhaul, accelerates decision-making at the network edge, and supports scalable IoT analytics.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table
 P00375-B21 |  875581-B21 |  880264-B21 |  880266-B21 |  877829-B21 | |
|---|---|---|---|---|---|
| Product Type | Hard Drive | Hard Drive | Hard Drive | Hard Drive | Hard Drive |
| Drive Type | HDD | HDD | HDD | HDD | HDD |
| Use Case | Desktop / Server / NAS / Surveillance / Enterprise Storage | Desktop / Server / NAS / Surveillance / Enterprise Storage | Desktop / Server / NAS / Surveillance / Enterprise Storage | Server / Enterprise Storage | Desktop / Server / NAS / Surveillance / Enterprise Storage |
| Interface | SAS 12Gb/s | SATA III | SATA III | SATA III | SATA III |
| Form Factor | 3.5-inch | 3.5-inch | 3.5-inch | 3.5-inch | 3.5-inch |
| Storage Capacity | 10 TB | 8 TB | 4 TB | 8 TB | 4 TB |
| Spindle Speed (RPM) | 7200 RPM | 7200 RPM | 7200 RPM | 7200 RPM | 7200 RPM |
| Cache (Buffer Size) | 256 MB | 256 MB | 128 MB | 256 MB | 128 MB |
| Average Latency | N/A | N/A | N/A | N/A | N/A |
| Data Transfer Rate | Up to 250 MB/s | Up to 250 MB/s | Up to 250 MB/s | Up to 250 MB/s | Up to 250 MB/s |
| Annual Workload Rating | 550 TB/yr | 180 TB/yr | 180 TB/yr | 550 TB/yr | 300 TB/yr |
| Power Consumption (Read/Write) | 8 Watts | 7 Watts | 8.0 Watts | 8 Watts | 8.5 Watts |
| Power Consumption (Idle) | 5 Watts | 4 Watts | 6.0 Watts | 5 Watts | 4.5 Watts |
| Encryption Support | AES 256-bit | AES 256-bit | AES 256-bit | AES 256-bit | AES 256-bit |
| Helium Sealed | Helium-Sealed | Helium-Sealed | Helium-Sealed | Helium-Sealed | Helium-Sealed |
| Drive Bays Supported | Multi-bay | Multi-bay | Multi-bay | Multi-bay | Multi-bay |
| Vibration Protection | Yes | Yes | Yes | Yes | Yes |
| Advanced Features | Dual Actuator | Dual Actuator | Rotational Vibration Sensors | Dual Actuator | Dual Actuator |
| Operating Temperature | 5–60°C | 5–60°C | 5–60°C | 5–60°C | 5–60°C |
| Product Name | P00375-B21 | 875581-B21 | 880264-B21 Enterprise 4TB SATA HDD | Seagate Exos X18 8TB 7200 RPM SATA III Enterprise HDD | 877829-B21 Enterprise Helium-Sealed HDD |
| Height | 1.03 inches | 1.03 inches | 1.03 inches | 1.0 inches | 1 inches |
| Width | 5.79 inches | 5.79 inches | 5.75 inches | 5.8 inches | 5.8 inches |
| Depth | 4.00 inches | 4 inches | 4.02 inches | 4.0 inches | 4 inches |
| Weight | 1.55 lbs | 2.2 lbs | 1.55 lbs | 1.8 lbs | 1.5 lbs |
Reviews & Ratings
A
Arif Hussain
4
Consistent throughput and low latency.
D
Daniel Kim
5
OEM quality storage.
W
Waleed Khan
3
Good for enterprise caching.
R
Rasmus Lind
4
Strong performance.
Questions & Answers
What is the storage capacity of the HPE P00375-B21 NVMe SSD?
The HPE P00375-B21 NVMe SSD delivers 2048 GB of usable storage capacity in an M.2 2280 form factor.
Which interface and PCIe lanes does the HPE 2048GB NVMe X4 RI M.2 2280 use?
It uses the NVMe 1.4 protocol over a PCIe Gen4 x4 interface to maximize throughput and minimize latency.
What are the sequential read and write performance specifications?
The drive achieves up to 7,000 MB/s sequential reads and up to 5,100 MB/s sequential writes under optimal conditions.
What random IOPS can I expect from this HPE NVMe SSD?
It delivers up to 1.2 million random read IOPS and up to 300,000 random write IOPS at QD32.