United States$5,000,000+
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E
Edward Hughes
5
Strong throughput with DNA features enabled. Very reliable.
ISR4351-DNA
Cisco ISR 4351 (3GE,3NIM,2SM,4G FLASH,4G DRAM,IPB) with DNA
FEATURED DEAL
Name:
ISR4351-DNA
- Description:
- Cisco ISR 4351 (3GE,3NIM,2SM,4G FLASH,4G DRAM,IPB) with DNA
- Rating:
Added to cart 28 times recently
- Availability:
In stock - Ready to Ship
- Brand:
- Cisco
- GTIN:
- 430816355740
- Condition:
- Warranty:
- 3
- List Price:
$11,368.32
- Price:
$7,048.3638% off
Quantity:
1
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ISR4351-DNA Overview
ISR4351-DNA is a high-performance enterprise router engineered with a modular architecture that integrates advanced security, VPN capabilities, and seamless network management. Designed for dynamic branch environments, it offers flexible power options including redundant AC power supplies, robust WAN/LAN interfaces with modular expansion support, and integrated services that cater to voice, video, and WAN optimization requirements.
ISR4351-DNA delivers industry-leading throughput capacity and redundancy for mission-critical applications while maintaining a compact, rack-mount form factor. Its VPN features ensure secure remote connectivity and its integrated performance and reliability make it an ideal solution for enterprise branch offices looking to consolidate network services while leveraging Cisco Digital Network Architecture (DNA) for enhanced network intelligence.
ISR4351-DNA price is $7,048.36, a 38% saving from the Cisco list price of $11,368.32. ISR4351-DNA is in stock and available for next-day dispatch. (terms applied)
Request bulk order quote for ISR4351-DNA for additional pricing. Browse the full Router Isr 4000 series or explore all Cisco products.
ISR4351-DNA Specifications
- Product Type
- Enterprise Router
- VPN Support
- IPSec / SSL VPN / DMVPN / FlexVPN / N/A
- Power Source
- AC Power Supply / Redundant
- Routing Protocols
- OSPF / BGP / EIGRP / RIP / Static Routing
- Broadband
- N/A
- Architecture
- Modular
- WAN Configuration
- Dual WAN
- WAN Ports
- Modular WAN
- LAN Ports
- Modular LAN
- Ethernet Technology
- 10/100/1000
- Wi-Fi Standard
- N/A
- Connectivity Type
- Wired
- Network Protocols
- IPv4 / IPv6
- Remote Management
- CLI / SNMP / Cisco DNA Center
- Compliance Standards
- FCC / CE
- Wireless Support
- No
- Speed/Capacity
- Gigabit
- Firewall Features
- Yes
- Features
- VPN / Firewall / Voice / Video / WAN Optimization
- Use Case
- Enterprise
- Management
- Managed
- Form Factor
- Rack-mount
- Integrated Services
- Voice / Video / WAN Optimization
- High Availability Support
- Supported
- Safety
- N/A
- EMC
- N/A
- Telecom
- N/A
- Throughput Capacity
- 1 Gbps
- QoS Features
- Supported
- Built-in Security Features
- Firewall / Intrusion Prevention / Malware Protection
- Expansion Slots
- EHWIC
- Modular Slots Available
- 2 Slots
- Stacking Capability
- No
- 5G Support
- No
- Memory
- 4 GB
- Flash Memory
- 256 MB
- Interface Ports
- RJ-45 / SFP
- Power
- 115W
- Device Type
- Router
- Product Name
- Cisco ISR4351-DNA
- Height
- N/A
- Width
- N/A
- Depth
- N/A
- Weight
- N/A
ISR4351-DNA Use Case
Secure SD-WAN for Multi-Branch Retail with ISR4351-DNA-Cisco ISR 4351
A national retail chain deploys the ISR4351-DNA-Cisco ISR 4351 (3GE, 3NIM, 2SM, 4G FLASH, 4G DRAM, IPB) with Cisco DNA to unify and secure WAN connectivity across 200 stores. Integrated Cisco DNA Center automation delivers zero-touch provisioning, continuous policy enforcement, and real-time path optimization over Internet and MPLS, ensuring consistent application performance and PCI-compliant data protection. The result is a 35% reduction in operational costs, 50% faster branch roll-outs, and improved customer experience through reliable, secure transactions.
Scalable Cloud On-Ramp for Hybrid Enterprise with ISR4351-DNA
A multinational enterprise uses the ISR4351-DNA-Cisco ISR 4351 (3GE, 3NIM, 2SM, 4G FLASH, 4G DRAM, IPB) with Cisco DNA to create a resilient, high-throughput cloud on-ramp for AWS and Azure workloads. Leveraging Cisco DNA Center orchestration and embedded security, IT teams establish encrypted IPSec tunnels, dynamic routing, and automated compliance checks in under one hour. This approach delivers a 60% improvement in application responsiveness, seamless hybrid-cloud failover, and 40% lower TCO compared to standalone VPN appliances.
Edge Compute and Real-Time IoT Analytics in Manufacturing
A smart-factory pilot integrates the ISR4351-DNA-Cisco ISR 4351 (3GE, 3NIM, 2SM, 4G FLASH, 4G DRAM, IPB) with Cisco DNA to process high-velocity sensor data at the edge. With built-in multicore CPU and programmable NIM modules, the solution runs local analytics and machine-learning inference for predictive maintenance, while Cisco DNA Center enforces segment-to-segment zero-trust security. The outcome is 80% faster anomaly detection, 30% increased equipment uptime, and elimination of bandwidth bottlenecks by analyzing critical data on-premises.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table
 ISR4351-DNA |  ISR4461-VSEC/K9 |  ISR4461-V/K9 |  C1-CISCO4331/K9 |  ISR4331/K9 | |
|---|---|---|---|---|---|
| 5G Support | No | No | No | No | No |
| Architecture | Modular | Modular | Modular | Modular | Modular |
| Broadband | N/A | N/A | N/A | N/A | N/A |
| Built-in Security Features | Firewall / Intrusion Prevention / Malware Protection | Firewall / Intrusion Prevention / Malware Protection | Firewall / Intrusion Prevention / Malware Protection | Firewall, Intrusion Prevention, Malware Protection | Firewall, Intrusion Prevention, Malware Protection |
| Compliance Standards | FCC / CE | FCC, CE, RoHS | FCC / CE | FCC, CE | FCC, CE, RoHS |
| Connectivity Type | Wired | Wired | Wired | Wired | Wired |
| Depth | N/A | 18.3 inches | N/A | 16.5 inches | 16.34 inches |
| Device Type | Router | Router | Router | Router | Router |
| EMC | N/A | N/A | N/A | FCC Compliant | N/A |
| Ethernet Technology | 10/100/1000 | 10/100/1000 | 10/100/1000 | 10/100/1000 | 10/100/1000 |
| Expansion Slots | EHWIC | EHWIC | EHWIC / NIM | NIM / EHWIC | EHWIC / NIM |
| Features | VPN / Firewall / Voice / Video / WAN Optimization | VPN / VoIP / IPv6 Compatible / Firewall / MPLS | VPN / Voice / Video / WAN Optimization / Firewall | VPN, Voice, Video, Integrated Services, Firewall | VPN, IPv6 Compatible, Firewall, Integrated Services |
| Firewall Features | Yes | Yes | Yes | Yes | Yes |
| Flash Memory | 256 MB | 2 GB | 256 MB | 2 GB | 4 GB |
| Form Factor | Rack-mount | Rack-mount | Rack-mount | Rack-mount | Rack-mount |
| Height | N/A | 1.75 inches | N/A | 1.75 inches | 1.75 inches |
| High Availability Support | Supported | Supported | Supported | Supported | Supported |
| Integrated Services | Voice / Video / WAN Optimization | Voice / Video / WAN Optimization | Voice / Video / WAN Optimization | Voice, Video, WAN Optimization | Voice, Video, WAN Optimization |
| Interface Ports | RJ-45 / SFP | RJ-45 / SFP | RJ-45 / SFP | RJ-45, SFP | RJ-45, SFP |
| LAN Ports | Modular LAN | 4 LAN Ports | 4 LAN Ports | 4 LAN Ports | Modular LAN |
| Management | Managed | Managed | Managed | Managed | Managed |
| Memory | 4 GB | 4 GB | 2 GB | 4 GB | 4 GB |
| Modular Slots Available | 2 Slots | 2 Slots | 2 Slots | 2 Slots | 2 Slots |
| Network Protocols | IPv4 / IPv6 | IPv4, IPv6, MPLS | IPv4 / IPv6 | OSPF, BGP, EIGRP, RIP, MPLS | IPv4, IPv6, MPLS |
| Power | 115W | 305 W | 375 W | 115W | 150W |
| Power Source | AC Power Supply / Redundant | AC Power Supply / Redundant | AC Power Supply / Redundant Optional | AC Power Supply / Redundant | AC Power Supply / Redundant |
| Product Name | Cisco ISR4351-DNA | Cisco ISR 4461 Integrated Services Router - Security Enhanced | Cisco ISR4461-V/K9 Integrated Services Router | Cisco 4331 Integrated Services Router | Cisco ISR4331/K9 |
| Product Type | Enterprise Router | Enterprise Router | Enterprise Router | Enterprise Router | Enterprise Router |
| QoS Features | Supported | Supported | Supported | Supported | Supported |
| Remote Management | CLI / SNMP / Cisco DNA Center | SSH, Telnet, SNMP, NetConf | CLI / Telnet / SSH / SNMP | Cisco SDM, SSH, Telnet | Telnet, SSH, SNMP, NETCONF |
| Routing Protocols | OSPF / BGP / EIGRP / RIP / Static Routing | OSPF / BGP / EIGRP / MPLS / IS-IS / RIP / Static Routing | OSPF / BGP / EIGRP / RIP / Static Routing | OSPF / BGP / EIGRP / MPLS / IS-IS / RIP / Static Routing | OSPF / BGP / EIGRP / RIP / Static Routing |
| Safety | N/A | N/A | N/A | UL Listed | N/A |
| Speed/Capacity | Gigabit | Gigabit | Gigabit | Gigabit | Gigabit |
| Stacking Capability | No | No | Yes | Yes | No |
| Telecom | N/A | N/A | N/A | TIA/EIA | N/A |
| Throughput Capacity | 1 Gbps | 1 Gbps | 0.4 Gbps | 100 Mbps | 100 Mbps |
| Use Case | Enterprise | Enterprise | Enterprise / Business | Enterprise / Branch | Enterprise |
| VPN Support | IPSec / SSL VPN / DMVPN / FlexVPN / N/A | IPSec / SSL VPN / GRE / DMVPN / FlexVPN | IPSec / SSL VPN / DMVPN / FlexVPN | IPSec / SSL VPN / DMVPN / FlexVPN | IPSec / SSL VPN / DMVPN / FlexVPN |
| WAN Configuration | Dual WAN | Dual WAN | Dual WAN | Dual WAN | Dual WAN |
| WAN Ports | Modular WAN | 2 WAN | 2 WAN | 2 WAN | 2 WAN |
| Weight | N/A | 27 lbs | N/A | 17.6 lbs | 14.3 lbs |
| Wi-Fi Standard | N/A | N/A | N/A | N/A | N/A |
| Width | N/A | 17.5 inches | N/A | 17.3 inches | 17.41 inches |
| Wireless Support | No | No | No | No | No |
Reviews & Ratings
P
Patrick Sullivan
4
Modern management combined with solid routing performance.
C
Charles Newman
5
Cisco ISR stability with enhanced network visibility.
H
Henry Collins
3
Handles branch workloads efficiently. Easy to manage.
W
William Dawson
4
Good fit for enterprises moving toward automation.
Questions & Answers
What is the Cisco ISR 4351 with DNA (SKU: ISR4351-DNA)?
The Cisco ISR 4351 with DNA is a high-performance branch router featuring three onboard Gigabit Ethernet ports, three Network Interface Module slots, two Service Module slots, 4 GB Flash, 4 GB DRAM, and integrated Cisco Digital Network Architecture (DNA) software for simplified policy-based automation and analytics.
What are the key hardware specifications of the Cisco ISR 4351-DNA?
The ISR 4351-DNA delivers up to 100 Mbps of throughput (upgradable to 300 Mbps with Performance on Demand), offers three GE ports, three NIM slots, two SM slots, 4 GB Flash, 4 GB DRAM, and dual power-supply support for enhanced reliability.
Which Cisco DNA features are included in the ISR 4351-DNA package?
The ISR 4351-DNA includes Cisco DNA Essentials or Advantage, providing automated provisioning, policy-based segmentation, WAN optimization with SD-WAN, network assurance, and real-time analytics via Cisco DNA Center.
How does the Cisco ISR 4351-DNA improve network security?
It integrates Cisco Trust Anchor Technologies, next-generation firewall, intrusion prevention (NGIPS), URL filtering, and secure VPN to deliver end-to-end threat defense and policy enforcement at the branch.