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ISR4351-DNA

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Cisco ISR 4351 (3GE,3NIM,2SM,4G FLASH,4G DRAM,IPB) with DNA
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Extended protection, enterprise-grade.

All enterprise hardware is backed by a 3-year warranty — triple the industry standard — covering defects under normal use.

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Professional repairs & replacements.

If a hardware issue is confirmed, we’ll repair or replace the unit. Replacement parts carry either original or 3-month coverage.

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Once an RMA is approved, return the defective unit within 10 days. We handle the rest — no service gaps.

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Your warranty covers defects under normal use. For continued protection, avoid accidental damage, unauthorized repairs, third-party parts, or extreme environments.

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In some regions, return-to-factory or remote service may apply. On-site service depends on infrastructure availability.

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Return any product within 14 days of delivery if it doesn’t meet your technical or operational needs.

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Initiate returns with ease.

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Changed your mind? Get a refund (restocking fees may apply) or swap with another product.

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Covered for any early faults.

All equipment includes a 30-day replacement warranty. If something goes wrong, we’ll repair or swap it — fast.

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Replacements shipped in 10 days or less.

Once your return is inspected and approved, we dispatch the replacement promptly to keep your operations moving.

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RMA protocol keeps it smooth.

Just ensure all accessories and original packaging are intact — we’ll take care of the technical validation.

ISR4351-DNA

Cisco ISR 4351 (3GE,3NIM,2SM,4G FLASH,4G DRAM,IPB)...

$11,368.32

$7,048.36

45 in Global Warehouse Global Warehouse Img

$7,048.36

38% off

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ISR4351-DNA Use Case

Secure SD-WAN for Multi-Branch Retail with ISR4351-DNA-Cisco ISR 4351

A national retail chain deploys the ISR4351-DNA-Cisco ISR 4351 (3GE, 3NIM, 2SM, 4G FLASH, 4G DRAM, IPB) with Cisco DNA to unify and secure WAN connectivity across 200 stores. Integrated Cisco DNA Center automation delivers zero-touch provisioning, continuous policy enforcement, and real-time path optimization over Internet and MPLS, ensuring consistent application performance and PCI-compliant data protection. The result is a 35% reduction in operational costs, 50% faster branch roll-outs, and improved customer experience through reliable, secure transactions.

Scalable Cloud On-Ramp for Hybrid Enterprise with ISR4351-DNA

A multinational enterprise uses the ISR4351-DNA-Cisco ISR 4351 (3GE, 3NIM, 2SM, 4G FLASH, 4G DRAM, IPB) with Cisco DNA to create a resilient, high-throughput cloud on-ramp for AWS and Azure workloads. Leveraging Cisco DNA Center orchestration and embedded security, IT teams establish encrypted IPSec tunnels, dynamic routing, and automated compliance checks in under one hour. This approach delivers a 60% improvement in application responsiveness, seamless hybrid-cloud failover, and 40% lower TCO compared to standalone VPN appliances.

Edge Compute and Real-Time IoT Analytics in Manufacturing

A smart-factory pilot integrates the ISR4351-DNA-Cisco ISR 4351 (3GE, 3NIM, 2SM, 4G FLASH, 4G DRAM, IPB) with Cisco DNA to process high-velocity sensor data at the edge. With built-in multicore CPU and programmable NIM modules, the solution runs local analytics and machine-learning inference for predictive maintenance, while Cisco DNA Center enforces segment-to-segment zero-trust security. The outcome is 80% faster anomaly detection, 30% increased equipment uptime, and elimination of bandwidth bottlenecks by analyzing critical data on-premises.

Product Comparison Table

Cisco ISR 4331 (3GE,2NIM,1SM,4G FLASH,4G DRAM,IPB)
ISR4331/K9

Cisco ONE ISR 4331 (3GE.2NIM.1SM.4G FLASH.4G DRAM.IPB)
C1-CISCO4331/K9

Cisco ISR 4461 Voice Bundle
ISR4461-V/K9

Cisco ISR 4461 Bundle with UC & Sec Lic.
ISR4461-VSEC/K9

Cisco ISR 4351 (3GE,3NIM,2SM,4G FLASH,4G DRAM,IPB) with DNA
ISR4351-DNA

5G Support No No No No No
Architecture Modular Modular Modular Modular Modular
Broadband N/A N/A N/A N/A N/A
Built-in Security Features Firewall, Intrusion Prevention, Malware Protection Firewall, Intrusion Prevention, Malware Protection Firewall / Intrusion Prevention / Malware Protection Firewall / Intrusion Prevention / Malware Protection Firewall / Intrusion Prevention / Malware Protection
Compliance Standards FCC, CE, RoHS FCC, CE FCC / CE FCC, CE, RoHS FCC / CE
Connectivity Type Wired Wired Wired Wired Wired
Depth 16.34 inches 16.5 inches N/A 18.3 inches N/A
Device Type Router Router Router Router Router
EMC N/A FCC Compliant N/A N/A N/A
Ethernet Technology 10/100/1000 10/100/1000 10/100/1000 10/100/1000 10/100/1000
Expansion Slots EHWIC / NIM NIM / EHWIC EHWIC / NIM EHWIC EHWIC
Features VPN, IPv6 Compatible, Firewall, Integrated Services VPN, Voice, Video, Integrated Services, Firewall VPN / Voice / Video / WAN Optimization / Firewall VPN / VoIP / IPv6 Compatible / Firewall / MPLS VPN / Firewall / Voice / Video / WAN Optimization
Firewall Features Yes Yes Yes Yes Yes
Flash Memory 4 GB 2 GB 256 MB 2 GB 256 MB
Form Factor Rack-mount Rack-mount Rack-mount Rack-mount Rack-mount
Height 1.75 inches 1.75 inches N/A 1.75 inches N/A
High Availability Support Supported Supported Supported Supported Supported
Integrated Services Voice, Video, WAN Optimization Voice, Video, WAN Optimization Voice / Video / WAN Optimization Voice / Video / WAN Optimization Voice / Video / WAN Optimization
Interface Ports RJ-45, SFP RJ-45, SFP RJ-45 / SFP RJ-45 / SFP RJ-45 / SFP
LAN Ports Modular LAN 4 LAN Ports 4 LAN Ports 4 LAN Ports Modular LAN
Management Managed Managed Managed Managed Managed
Memory 4 GB 4 GB 2 GB 4 GB 4 GB
Modular Slots Available 2 Slots 2 Slots 2 Slots 2 Slots 2 Slots
Network Protocols IPv4, IPv6, MPLS OSPF, BGP, EIGRP, RIP, MPLS IPv4 / IPv6 IPv4, IPv6, MPLS IPv4 / IPv6
Power 150W 115W 375 W 305 W 115W
Power Source AC Power Supply / Redundant AC Power Supply / Redundant AC Power Supply / Redundant Optional AC Power Supply / Redundant AC Power Supply / Redundant
Product Name Cisco ISR4331/K9 Cisco 4331 Integrated Services Router Cisco ISR4461-V/K9 Integrated Services Router Cisco ISR 4461 Integrated Services Router - Security Enhanced Cisco ISR4351-DNA
Product Type Enterprise Router Enterprise Router Enterprise Router Enterprise Router Enterprise Router
QoS Features Supported Supported Supported Supported Supported
Remote Management Telnet, SSH, SNMP, NETCONF Cisco SDM, SSH, Telnet CLI / Telnet / SSH / SNMP SSH, Telnet, SNMP, NetConf CLI / SNMP / Cisco DNA Center
Routing Protocols OSPF / BGP / EIGRP / RIP / Static Routing OSPF / BGP / EIGRP / MPLS / IS-IS / RIP / Static Routing OSPF / BGP / EIGRP / RIP / Static Routing OSPF / BGP / EIGRP / MPLS / IS-IS / RIP / Static Routing OSPF / BGP / EIGRP / RIP / Static Routing
Safety N/A UL Listed N/A N/A N/A
Speed/Capacity Gigabit Gigabit Gigabit Gigabit Gigabit
Stacking Capability No Yes Yes No No
Telecom N/A TIA/EIA N/A N/A N/A
Throughput Capacity 100 Mbps 100 Mbps 0.4 Gbps 1 Gbps 1 Gbps
Use Case Enterprise Enterprise / Branch Enterprise / Business Enterprise Enterprise
VPN Support IPSec / SSL VPN / DMVPN / FlexVPN IPSec / SSL VPN / DMVPN / FlexVPN IPSec / SSL VPN / DMVPN / FlexVPN IPSec / SSL VPN / GRE / DMVPN / FlexVPN IPSec / SSL VPN / DMVPN / FlexVPN / N/A
WAN Configuration Dual WAN Dual WAN Dual WAN Dual WAN Dual WAN
WAN Ports 2 WAN 2 WAN 2 WAN 2 WAN Modular WAN
Weight 14.3 lbs 17.6 lbs N/A 27 lbs N/A
Wi-Fi Standard N/A N/A N/A N/A N/A
Width 17.41 inches 17.3 inches N/A 17.5 inches N/A
Wireless Support No No No No No

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