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ISR4221/K9
Cisco ISR 4221 (2GE,2NIM,8G FLASH,4G DRAM,IPB)
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ISR4221/K9 is a fixed, enterprise-class router engineered for branch deployments with integrated services that ensure robust VPN features, comprehensive security, and high-performance routing. It delivers flexible power options through an AC Power Supply, supports dual WAN configurations with dedicated 10/100/1000 Ethernet ports for both WAN and LAN connectivity, and offers modular capabilities via EHWIC slots for enhanced network expansion.
ISR4221/K9 integrates advanced routing protocols including OSPF, EIGRP, BGP, and RIP, while its built-in firewall and VPN support (IPSec, SSL VPN, DMVPN) guarantee secure data transmission. Designed to handle up to 0.3 Gbps throughput with high availability and redundancy, it is ideally suited for enterprise environments requiring unified communications, voice and video services, and robust WAN optimization without compromise.
ISR4221/K9 price is $625.00, a 70.7% saving from the Cisco list price of $2,131.00. ISR4221/K9 is in stock and available for next-day dispatch. (terms applied)
Request bulk order quote for ISR4221/K9 for additional pricing. Browse the full Router Isr 4000 series or explore all Cisco products.
In a multinational enterprise deploying Cisco SD-WAN at remote sites, the Cisco ISR4221/K9 serves as a compact yet powerful SD-WAN edge router. Leveraging its dual GE WAN interfaces, two NIM slots for 4G-LTE backup, 8 GB Flash and 4 GB DRAM, it delivers encrypted tunnels, application-aware routing, and zero-touch provisioning across 50+ branch locations. Outcome: 99.9% uptime, 40% reduction in operational expenses, and consistent user experience.
An SMB retail chain uses the Cisco ISR4221/K9 as a unified threat management appliance. Built-in Cisco zone-based firewall, IPS, and NAT combine with 8 GB Flash and the IP Base license to secure POS transactions and guest Wi-Fi. Dual 1 GE interfaces support WAN diversification while rapid firmware upgrades are stored on flash. Outcome: PCI-DSS compliance, 30% faster threat response, and 25% lower total cost of ownership.
A manufacturing plant aggregates IoT sensors, surveillance cameras, and VoIP phones through the Cisco ISR4221/K9. Two NIM slots enable WAN redundancy and LTE failover; advanced QoS prioritizes voice and machine-critical data; and the IP Base license enforces secure segmentation. Outcome: 50% improvement in real-time monitoring accuracy, 20% boost in production efficiency, and simplified centralized network management.
To get the detailed certification, please go to the Compliance Center.
| ISR4221/K9 |  ISR4321-SEC/K9 |  C1-CISCO4331/K9 |  C1-CISCO4321/K9 |  ISR4221-SEC/K9 | |
|---|---|---|---|---|---|
| 5G Support | No | No | No | No | No |
| Architecture | Fixed | Fixed | Modular | Modular | Fixed |
| Broadband | N/A | N/A | N/A | N/A | N/A |
| Built-in Security Features | Firewall / Intrusion Prevention / Malware Protection | Firewall, Intrusion Prevention, Malware Protection | Firewall, Intrusion Prevention, Malware Protection | Firewall / Intrusion Prevention | Firewall / Intrusion Prevention |
| Compliance Standards | FCC / CE | FCC, CE | FCC, CE | FCC / CE | IEEE 802.3, FCC, CE |
| Connectivity Type | Wired | Wired | Wired | Wired | Wired |
| Depth | 15.7 inches | N/A | 16.5 inches | 20 inches | 11.3 inches |
| Device Type | Router | Router | Router | Router | Router |
| EMC | N/A | N/A | FCC Compliant | N/A | CISPR 22 |
| Ethernet Technology | 10/100/1000 | 10/100/1000 | 10/100/1000 | 10/100/1000 | 10/100/1000 |
| Expansion Slots | EHWIC | NIM, EHWIC | NIM / EHWIC | NIM / EHWIC | EHWIC |
| Features | VPN / VoIP / IPv6 Compatible / Firewall / MPLS / QoS | VPN, Firewall, IPv6 Compatible | VPN, Voice, Video, Integrated Services, Firewall | VPN / VoIP / IPv6 Compatible / Firewall / WAN Optimization | VPN / IPv6 Compatible / Firewall |
| Firewall Features | Yes | Yes | Yes | Yes | Yes |
| Flash Memory | 256 MB | 1 GB | 2 GB | 512 MB | 1 GB |
| Form Factor | Rack-mount | Rack-mount | Rack-mount | Rack-mount | Desktop |
| Height | 1.73 inches | N/A | 1.75 inches | 1.75 inches | 1.73 inches |
| High Availability Support | Supported | Supported | Supported | Supported | Supported |
| Integrated Services | Voice / Video | Voice, Video, WAN Optimization | Voice, Video, WAN Optimization | Voice / Video / WAN Optimization | Voice / Video |
| Interface Ports | RJ-45 / EHWIC | RJ-45, SFP | RJ-45, SFP | RJ-45 / SFP | RJ-45 |
| LAN Ports | 4 LAN Ports | 2 LAN Ports | 4 LAN Ports | Modular LAN | 4 LAN Ports |
| Management | Managed | Managed | Managed | Managed | Managed |
| Memory | 1 GB | 2 GB | 4 GB | 1 GB | 1 GB |
| Modular Slots Available | 2 Slots | 1 Slot | 2 Slots | 2 Slots | 1 Slot |
| Network Protocols | IPv4 / IPv6 / OSPF / EIGRP / BGP / RIP | IPv4, IPv6 | OSPF, BGP, EIGRP, RIP, MPLS | IPv4, IPv6 | IPv4, IPv6 |
| Power | 65 Watt | 75W | 115W | 110 W | 65W |
| Power Source | AC Power Supply | AC Power Supply / DC Power Supply (Redundant) | AC Power Supply / Redundant | AC Power Supply with Redundant Options | AC Power Supply / Redundant |
| Product Name | Cisco ISR 4221/K9 | Cisco ISR4321-SEC/K9 | Cisco 4331 Integrated Services Router | Cisco 4321 Integrated Services Router (C1-CISCO4321/K9) | Cisco ISR 4221-SEC/K9 |
| Product Type | Enterprise Router | Enterprise Router | Enterprise Router | Enterprise Router | Enterprise Router |
| QoS Features | Supported | Supported | Supported | Supported | Supported |
| Remote Management | CLI / SNMP / Cisco SDM | SSH, Telnet, SNMP | Cisco SDM, SSH, Telnet | SSH / Telnet / SNMP | SSH, Telnet, SNMP |
| Routing Protocols | OSPF / BGP / EIGRP / RIP / Static Routing | OSPF / BGP / EIGRP / RIP / Static Routing | OSPF / BGP / EIGRP / MPLS / IS-IS / RIP / Static Routing | OSPF / BGP / EIGRP / RIP / Static Routing | OSPF / BGP / EIGRP / RIP / Static Routing / MPLS |
| Safety | N/A | N/A | UL Listed | N/A | UL, cUL |
| Speed/Capacity | Gigabit | Gigabit | Gigabit | Gigabit | Gigabit |
| Stacking Capability | No | No | Yes | No | No |
| Telecom | N/A | N/A | TIA/EIA | N/A | FCC Part 15 |
| Throughput Capacity | 0.3 Gbps | 300 Mbps | 100 Mbps | 0.15 Gbps | 300 Mbps |
| Use Case | Enterprise | Enterprise, Small Business | Enterprise / Branch | Enterprise | Enterprise |
| VPN Support | IPSec / SSL VPN / DMVPN | IPSec / SSL VPN / DMVPN / FlexVPN | IPSec / SSL VPN / DMVPN / FlexVPN | IPSec / SSL VPN / DMVPN / FlexVPN | IPSec / SSL VPN / DMVPN / FlexVPN |
| WAN Configuration | Dual WAN | Dual WAN | Dual WAN | Dual WAN | Dual WAN |
| WAN Ports | 2 WAN | 2 WAN Ports | 2 WAN | 2 WAN | 2 WAN |
| Weight | 10.4 lbs | N/A | 17.6 lbs | 14 lbs | 8.6 lbs |
| Wi-Fi Standard | N/A | N/A | N/A | N/A | N/A |
| Width | 17.3 inches | N/A | 17.3 inches | 17.5 inches | 17.2 inches |
| Wireless Support | No | No | No | No | No |
Cisco ISR 4221 delivers stable routing and UC performance. Ideal for small offices with predictable workloads.
Durable and reliable. Supports 2GE, 2NIM, and multiple endpoints efficiently without downtime.
Easy to configure and maintain. Provides consistent UC, voice, and network operations across branch offices.
Reliable Cisco solution. Maintains seamless UC, voice, and data communications in small to medium branches.
High-performing and robust. Perfect for offices needing secure and reliable routing with UC support.
The Cisco ISR 4221 (SKU ISR4221/K9) is a compact branch router delivering integrated routing, security, and application services in a single platform.
Key features include two Gigabit Ethernet ports, two NIM expansion slots, 4 GB DRAM, 8 GB flash memory, hardware encryption, and an internal power supply.
The ISR 4221 delivers up to 50 Mbps aggregate throughput by default and can be boosted to 100 Mbps with an optional Performance on Demand license.
It features two 10/100/1000 Mbps RJ-45 ports and two Network Interface Module (NIM) slots supporting additional Ethernet, T1/E1, DSL, or cellular modules.
The router ships with 4 GB DDR4 DRAM for runtime operations and 8 GB of onboard flash storage for the operating system and configuration files.
Yes, the ISR 4221 supports Cisco IOS XE SD-WAN, enabling secure, centralized management and optimized WAN connectivity across branches.
It supports dynamic routing protocols (OSPF, EIGRP, BGP), MPLS, DMVPN, and policy-based routing for flexible branch deployments.
Built-in security includes AES-256 hardware encryption, firewall, intrusion prevention (IPS), secure boot, Trust Anchor module, and IPsec VPN termination.
The ISR 4221 includes an integrated universal AC power supply (100–240 VAC) and meets ENERGY STAR and EPEAT Gold standards for energy efficiency.
It ships in a compact desktop form factor and can be rack-mounted with an optional 1 RU kit for standard 19-inch racks.
The device runs Cisco IOS XE, a modular, programmable OS that supports service containers, model-driven telemetry, and on-box automation.
Use the built-in Cisco IOS CLI setup wizard via the console port to configure basic parameters (hostname, interfaces, routing) in minutes.
Licensing is modular: Right-to-Use (RtU) for Security, Unified Communications, IPv4/IPv6, and Performance on Demand to unlock higher throughput.
Manage via Cisco DNA Center, Cisco Prime Infrastructure, or on-box RESTCONF/NETCONF APIs for real-time monitoring, telemetry, and provisioning.
Cisco provides a 1-year limited hardware warranty with return-to-factory service and optional SMARTnet® for 24x7 support, advance replacement, and OS upgrades.