United StatesName:
Added to cart 28 times recently
In stock - Ready to Ship
3 Year Extended Warranty
Same-day Shipping
14-Day Money Back Guarantee
Shipping:
Payment:
3 Year Extended Warranty
Same-day Shipping
14-Day Money Back Guarantee
Need Additional Discount on Product?
Request a quote below - Get Exclusive Pricing and Support.
Shipping:
Payment:
ISR4221-AX/K9
Cisco ISR 4221 AX Bundle w/APP, SEC lic
TRUSTED, TRIED, PROVEN
Inventory Delivered By
& Verified By
Solutions Powered By
ISR4221-AX/K9 is a robust enterprise router featuring a fixed architecture optimized for secure branch connectivity with integrated VPN, firewall, and advanced security services. It supports flexible power options with an AC power supply while providing modular expansion capabilities to address evolving network demands.
ISR4221-AX/K9 delivers comprehensive WAN/LAN interfaces with dual WAN ports and four LAN ports operating at 10/100/1000 speeds, and integrates services including voice, video, and WAN optimization. Its high throughput, reliable VPN features, and performance-enhanced design make it an ideal choice for enterprise branch offices, small businesses, and remote sites needing secure and scalable connectivity.
ISR4221-AX/K9 price is is available on request. Get immediate quote.
Request bulk order quote for ISR4221-AX/K9 for additional pricing. Browse the full Router Isr 4000 series or explore all Cisco products.
A multinational retail chain deploys Cisco ISR 4221 AX Bundle w/APP, SEC lic at new branch locations to establish encrypted IPsec VPN tunnels, enable next-generation firewall and intrusion prevention. Outcome: Unified, zero-trust network segmentation across 50+ sites, 40% reduction in security incidents and full compliance with PCI DSS.
A global professional services firm leverages the ISR 4221 AX APP license to dynamically route critical SaaS and UC traffic over broadband or MPLS links based on real-time performance metrics. Outcome: Consistent sub-50 ms latency for cloud applications, 30% lower WAN costs and centralized policy enforcement via Cisco DNA Center.
A mid-market manufacturing company uses Cisco ISR 4221 AX Bundle w/APP, SEC lic as a dedicated on-ramp router to AWS and Azure, combining DMVPN, direct connect and integrated threat defense. Outcome: 50% faster cloud workload provisioning, end-to-end encryption, and unified security posture across on-premises and public cloud environments.
To get the detailed certification, please go to the Compliance Center.
| ISR4221-AX/K9 |  ISR4351-DNA |  ISR4321-SEC/K9 |  ISR4331-VSEC/K9 |  ISR4431-DNA | |
|---|---|---|---|---|---|
| 5G Support | No | No | No | No | No |
| Architecture | Fixed | Modular | Fixed | Modular | Modular |
| Broadband | N/A | N/A | N/A | N/A | N/A |
| Built-in Security Features | Firewall / Intrusion Prevention | Firewall / Intrusion Prevention / Malware Protection | Firewall, Intrusion Prevention, Malware Protection | Firewall / Intrusion Prevention / Malware Protection | Firewall / Intrusion Prevention / Malware Protection |
| Compliance Standards | FCC / CE / UL | FCC / CE | FCC, CE | FCC / CE / UL | IEEE / FCC / CE |
| Connectivity Type | Wired | Wired | Wired | Wired | Wired |
| Depth | 12 inches | N/A | N/A | 15.1 inches | N/A |
| Device Type | Router | Router | Router | Router | Router |
| EMC | N/A | N/A | N/A | N/A | N/A |
| Ethernet Technology | 10/100/1000 | 10/100/1000 | 10/100/1000 | 10/100/1000 | 10/100/1000 |
| Expansion Slots | EHWIC / NIM | EHWIC | NIM, EHWIC | NIM | EHWIC / NIM / SFP+ |
| Features | VPN / Firewall / IPv6 Compatible | VPN / Firewall / Voice / Video / WAN Optimization | VPN, Firewall, IPv6 Compatible | VPN / IPv6 Compatible / Firewall / MPLS | VPN / Firewall / VoIP / IPv6 Compatible / MPLS / Integrated Services |
| Firewall Features | Yes | Yes | Yes | Yes | Yes |
| Flash Memory | 256 MB | 256 MB | 1 GB | 512 MB | 512 MB |
| Form Factor | Rack-mount | Rack-mount | Rack-mount | Rack-mount | Rack-mount |
| Height | 1.75 inches | N/A | N/A | 1.75 inches | N/A |
| High Availability Support | Not Supported | Supported | Supported | Supported | Supported |
| Integrated Services | Voice / Video / WAN Optimization | Voice / Video / WAN Optimization | Voice, Video, WAN Optimization | Voice / Video / WAN Optimization | Voice / Video / WAN Optimization |
| Interface Ports | RJ-45, SFP | RJ-45 / SFP | RJ-45, SFP | RJ-45 | RJ-45 / SFP |
| LAN Ports | 4 LAN Ports | Modular LAN | 2 LAN Ports | Modular LAN | 4 LAN Ports |
| Management | Managed | Managed | Managed | Managed | Managed |
| Memory | 1 GB | 4 GB | 2 GB | 4 GB | 4 GB |
| Modular Slots Available | 1 Slot | 2 Slots | 1 Slot | 2 Slots | 3+ Slots |
| Network Protocols | IPv4, IPv6, MPLS | IPv4 / IPv6 | IPv4, IPv6 | IPv4, IPv6 | IPv4, IPv6, MPLS |
| Power | 70 Watt | 115W | 75W | 130 W | 150 W |
| Power Source | AC Power Supply | AC Power Supply / Redundant | AC Power Supply / DC Power Supply (Redundant) | AC Power Supply / Redundant | AC Power Supply / DC Power Supply / Redundant |
| Product Name | Cisco ISR 4221 Integrated Services Router | Cisco ISR4351-DNA | Cisco ISR4321-SEC/K9 | Cisco ISR 4331 Secure Integrated Services Router | ISR4431-DNA |
| Product Type | Enterprise Router | Enterprise Router | Enterprise Router | Enterprise Router | Enterprise Router |
| QoS Features | Supported | Supported | Supported | Supported | Supported |
| Remote Management | SSH, Telnet, SNMP | CLI / SNMP / Cisco DNA Center | SSH, Telnet, SNMP | SSH, Telnet, SNMP | SSH / Telnet / SNMP / NETCONF |
| Routing Protocols | OSPF / BGP / EIGRP / RIP / Static Routing | OSPF / BGP / EIGRP / RIP / Static Routing | OSPF / BGP / EIGRP / RIP / Static Routing | OSPF / BGP / EIGRP / RIP / Static Routing | OSPF / BGP / EIGRP / MPLS / IS-IS / RIP / Static Routing |
| Safety | N/A | N/A | N/A | N/A | N/A |
| Speed/Capacity | Gigabit | Gigabit | Gigabit | Gigabit | Gigabit |
| Stacking Capability | No | No | No | No | No |
| Telecom | N/A | N/A | N/A | N/A | N/A |
| Throughput Capacity | 0.25 Gbps | 1 Gbps | 300 Mbps | 0.1 Gbps | 1.2 Gbps |
| Use Case | Enterprise / Branch Office | Enterprise | Enterprise, Small Business | Enterprise | Enterprise |
| VPN Support | IPSec / SSL VPN | IPSec / SSL VPN / DMVPN / FlexVPN / N/A | IPSec / SSL VPN / DMVPN / FlexVPN | IPSec / SSL VPN / DMVPN / FlexVPN | IPSec / SSL VPN / GRE / DMVPN / FlexVPN |
| WAN Configuration | Dual WAN | Dual WAN | Dual WAN | Dual WAN | Dual WAN |
| WAN Ports | 2 WAN | Modular WAN | 2 WAN Ports | Modular WAN | Modular WAN |
| Weight | 10 lbs | N/A | N/A | 11 lbs | N/A |
| Wi-Fi Standard | N/A | N/A | N/A | N/A | N/A |
| Width | 17.6 inches | N/A | N/A | 17.5 inches | N/A |
| Wireless Support | No | No | No | No | No |
AX bundle delivered strong security and application performance. Ideal for small branches needing modern features without complexity.
Stable routing with security enabled. Setup was smooth and day to day management is straightforward.
Good balance of performance and cost. Works reliably for branch connectivity.
Cisco reliability with useful AX features. No issues in production.
Meets expectations for secure branch routing. Consistent uptime.
The Cisco ISR 4221 AX Bundle w/APP, SEC lic (SKU ISR4221-AX/K9) is a fixed-port integrated services router with Cisco IOS XE, application-hosting capabilities, and an advanced Security license for firewall, IPS, AMP, URL filtering, and VPN encryption.
The ISR 4221 AX features two Gigabit Ethernet ports, USB and console ports, 4 GB DRAM, 4 GB flash memory, an integrated Application Hosting module, and supports up to 50 Mbps aggregated WAN throughput in a compact desktop or rack-mountable design.
With the AX Bundle and SEC license enabled, the ISR 4221 delivers up to 50 Mbps of aggregate WAN throughput, hardware-accelerated AES-256 encryption, and consistent performance under full security-service load.
The Security (SEC) license includes Cisco IOS XE Firewall, Next-Generation Intrusion Prevention (NGIPS), Advanced Malware Protection (AMP), URL Filtering, and site-to-site IPsec VPN with AES-256 encryption.
Yes. The integrated Application Hosting (APP) module supports Docker containers and custom Linux-based applications, enabling local processing, analytics, and edge-services deployment.
Yes. The ISR 4221 AX running IOS XE is fully SD-WAN ready and can be managed via Cisco SD-WAN vManage for centralized policy enforcement, path control, and telemetry.
Cisco IOS XE powers the ISR 4221 AX, offering modular services, programmability via RESTCONF/NETCONF, and integration with Cisco DNA Center for automated provisioning and policy management.
You can configure site-to-site IPsec VPN and AnyConnect SSL VPN via CLI templates, Cisco Configuration Professional, or Cisco DNA Center, leveraging hardware crypto acceleration for high performance.
The ISR 4221 AX is supported by Cisco DNA Center, Cisco Prime Infrastructure, Cisco SD-WAN vManage, and open APIs (RESTCONF/NETCONF) for full life-cycle management and telemetry.
You can purchase the SEC license as a perpetual Cisco IOS XE license (K9) or as a subscription under Cisco Smart Licensing, providing flexible renewal and compliance tracking.
The ISR 4221 AX is ideal for small to medium branch offices, retail outlets, and remote or micro-branch sites that require secure WAN connectivity with local application hosting.
Yes. You can upgrade DRAM and flash, activate additional IOS XE feature licenses, or add security subscriptions to scale performance and service capabilities as your network grows.
The ISR 4221 AX supports 12–24 V DC or 100–240 V AC input, consumes up to 40 W, and operates between 0 °C and 40 °C in desktop or 1U rack-mount form factor.
Cisco provides a 90-day limited hardware warranty by default. For enhanced SLA, access to software updates, and 24/7 technical assistance, you can purchase Cisco SMARTnet service.
Order SKU ISR4221-AX/K9 through Cisco authorized resellers, distributors, or Cisco’s online portal. Contact your Cisco partner for pricing, lead times, and configuration guidance.
Yes. The ISR 4221 AX supports secure connectivity to AWS, Microsoft Azure, and Google Cloud via VPN or Cisco Cloud OnRamp for SaaS, enabling optimized cloud access.
Keep IOS XE up to date, enable hardware offload for encryption, right-size security profiles, and implement QoS policies to prioritize critical applications and maintain consistent throughput.