United States$5,000,000+
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M
Michael Harrington
5
AX bundle delivered strong security and application performance. Ideal for small branches needing modern features without complexity.
ISR4221-AX/K9
Cisco ISR 4221 AX Bundle w/APP, SEC lic
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Name:
ISR4221-AX/K9
- Description:
- Cisco ISR 4221 AX Bundle w/APP, SEC lic
- Rating:
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- Brand:
- Cisco
- GTIN:
- 659821191628
- Condition:
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ISR4221-AX/K9 Overview
ISR4221-AX/K9 is a robust enterprise router featuring a fixed architecture optimized for secure branch connectivity with integrated VPN, firewall, and advanced security services. It supports flexible power options with an AC power supply while providing modular expansion capabilities to address evolving network demands.
ISR4221-AX/K9 delivers comprehensive WAN/LAN interfaces with dual WAN ports and four LAN ports operating at 10/100/1000 speeds, and integrates services including voice, video, and WAN optimization. Its high throughput, reliable VPN features, and performance-enhanced design make it an ideal choice for enterprise branch offices, small businesses, and remote sites needing secure and scalable connectivity.
ISR4221-AX/K9 price is is available on request. Get immediate quote.
Request bulk order quote for ISR4221-AX/K9 for additional pricing. Browse the full Router Isr 4000 series or explore all Cisco products.
ISR4221-AX/K9 Specifications
- Product Type
- Enterprise Router
- VPN Support
- IPSec / SSL VPN
- Power Source
- AC Power Supply
- Routing Protocols
- OSPF / BGP / EIGRP / RIP / Static Routing
- Broadband
- N/A
- Architecture
- Fixed
- WAN Configuration
- Dual WAN
- WAN Ports
- 2 WAN
- LAN Ports
- 4 LAN Ports
- Ethernet Technology
- 10/100/1000
- Wi-Fi Standard
- N/A
- Connectivity Type
- Wired
- Network Protocols
- IPv4, IPv6, MPLS
- Remote Management
- SSH, Telnet, SNMP
- Compliance Standards
- FCC / CE / UL
- Wireless Support
- No
- Speed/Capacity
- Gigabit
- Firewall Features
- Yes
- Features
- VPN / Firewall / IPv6 Compatible
- Use Case
- Enterprise / Branch Office
- Management
- Managed
- Form Factor
- Rack-mount
- Integrated Services
- Voice / Video / WAN Optimization
- High Availability Support
- Not Supported
- Safety
- N/A
- EMC
- N/A
- Telecom
- N/A
- Throughput Capacity
- 0.25 Gbps
- QoS Features
- Supported
- Built-in Security Features
- Firewall / Intrusion Prevention
- Expansion Slots
- EHWIC / NIM
- Modular Slots Available
- 1 Slot
- Stacking Capability
- No
- 5G Support
- No
- Memory
- 1 GB
- Flash Memory
- 256 MB
- Interface Ports
- RJ-45, SFP
- Power
- 70 Watt
- Device Type
- Router
- Product Name
- Cisco ISR 4221 Integrated Services Router
- Height
- 1.75 inches
- Width
- 17.6 inches
- Depth
- 12 inches
- Weight
- 10 lbs
ISR4221-AX/K9 Use Case
ISR4221-AX/K9 for Secure Branch Office Connectivity
A multinational retail chain deploys Cisco ISR 4221 AX Bundle w/APP, SEC lic at new branch locations to establish encrypted IPsec VPN tunnels, enable next-generation firewall and intrusion prevention. Outcome: Unified, zero-trust network segmentation across 50+ sites, 40% reduction in security incidents and full compliance with PCI DSS.
Application-Aware SD-WAN Optimization with ISR4221-AX/K9
A global professional services firm leverages the ISR 4221 AX APP license to dynamically route critical SaaS and UC traffic over broadband or MPLS links based on real-time performance metrics. Outcome: Consistent sub-50 ms latency for cloud applications, 30% lower WAN costs and centralized policy enforcement via Cisco DNA Center.
Hybrid Cloud On-Ramp and Secure IaaS Connectivity
A mid-market manufacturing company uses Cisco ISR 4221 AX Bundle w/APP, SEC lic as a dedicated on-ramp router to AWS and Azure, combining DMVPN, direct connect and integrated threat defense. Outcome: 50% faster cloud workload provisioning, end-to-end encryption, and unified security posture across on-premises and public cloud environments.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table
 ISR4221-AX/K9 |  ISR4351-DNA |  ISR4321-SEC/K9 |  ISR4331-VSEC/K9 |  ISR4431-DNA | |
|---|---|---|---|---|---|
| 5G Support | No | No | No | No | No |
| Architecture | Fixed | Modular | Fixed | Modular | Modular |
| Broadband | N/A | N/A | N/A | N/A | N/A |
| Built-in Security Features | Firewall / Intrusion Prevention | Firewall / Intrusion Prevention / Malware Protection | Firewall, Intrusion Prevention, Malware Protection | Firewall / Intrusion Prevention / Malware Protection | Firewall / Intrusion Prevention / Malware Protection |
| Compliance Standards | FCC / CE / UL | FCC / CE | FCC, CE | FCC / CE / UL | IEEE / FCC / CE |
| Connectivity Type | Wired | Wired | Wired | Wired | Wired |
| Depth | 12 inches | N/A | N/A | 15.1 inches | N/A |
| Device Type | Router | Router | Router | Router | Router |
| EMC | N/A | N/A | N/A | N/A | N/A |
| Ethernet Technology | 10/100/1000 | 10/100/1000 | 10/100/1000 | 10/100/1000 | 10/100/1000 |
| Expansion Slots | EHWIC / NIM | EHWIC | NIM, EHWIC | NIM | EHWIC / NIM / SFP+ |
| Features | VPN / Firewall / IPv6 Compatible | VPN / Firewall / Voice / Video / WAN Optimization | VPN, Firewall, IPv6 Compatible | VPN / IPv6 Compatible / Firewall / MPLS | VPN / Firewall / VoIP / IPv6 Compatible / MPLS / Integrated Services |
| Firewall Features | Yes | Yes | Yes | Yes | Yes |
| Flash Memory | 256 MB | 256 MB | 1 GB | 512 MB | 512 MB |
| Form Factor | Rack-mount | Rack-mount | Rack-mount | Rack-mount | Rack-mount |
| Height | 1.75 inches | N/A | N/A | 1.75 inches | N/A |
| High Availability Support | Not Supported | Supported | Supported | Supported | Supported |
| Integrated Services | Voice / Video / WAN Optimization | Voice / Video / WAN Optimization | Voice, Video, WAN Optimization | Voice / Video / WAN Optimization | Voice / Video / WAN Optimization |
| Interface Ports | RJ-45, SFP | RJ-45 / SFP | RJ-45, SFP | RJ-45 | RJ-45 / SFP |
| LAN Ports | 4 LAN Ports | Modular LAN | 2 LAN Ports | Modular LAN | 4 LAN Ports |
| Management | Managed | Managed | Managed | Managed | Managed |
| Memory | 1 GB | 4 GB | 2 GB | 4 GB | 4 GB |
| Modular Slots Available | 1 Slot | 2 Slots | 1 Slot | 2 Slots | 3+ Slots |
| Network Protocols | IPv4, IPv6, MPLS | IPv4 / IPv6 | IPv4, IPv6 | IPv4, IPv6 | IPv4, IPv6, MPLS |
| Power | 70 Watt | 115W | 75W | 130 W | 150 W |
| Power Source | AC Power Supply | AC Power Supply / Redundant | AC Power Supply / DC Power Supply (Redundant) | AC Power Supply / Redundant | AC Power Supply / DC Power Supply / Redundant |
| Product Name | Cisco ISR 4221 Integrated Services Router | Cisco ISR4351-DNA | Cisco ISR4321-SEC/K9 | Cisco ISR 4331 Secure Integrated Services Router | ISR4431-DNA |
| Product Type | Enterprise Router | Enterprise Router | Enterprise Router | Enterprise Router | Enterprise Router |
| QoS Features | Supported | Supported | Supported | Supported | Supported |
| Remote Management | SSH, Telnet, SNMP | CLI / SNMP / Cisco DNA Center | SSH, Telnet, SNMP | SSH, Telnet, SNMP | SSH / Telnet / SNMP / NETCONF |
| Routing Protocols | OSPF / BGP / EIGRP / RIP / Static Routing | OSPF / BGP / EIGRP / RIP / Static Routing | OSPF / BGP / EIGRP / RIP / Static Routing | OSPF / BGP / EIGRP / RIP / Static Routing | OSPF / BGP / EIGRP / MPLS / IS-IS / RIP / Static Routing |
| Safety | N/A | N/A | N/A | N/A | N/A |
| Speed/Capacity | Gigabit | Gigabit | Gigabit | Gigabit | Gigabit |
| Stacking Capability | No | No | No | No | No |
| Telecom | N/A | N/A | N/A | N/A | N/A |
| Throughput Capacity | 0.25 Gbps | 1 Gbps | 300 Mbps | 0.1 Gbps | 1.2 Gbps |
| Use Case | Enterprise / Branch Office | Enterprise | Enterprise, Small Business | Enterprise | Enterprise |
| VPN Support | IPSec / SSL VPN | IPSec / SSL VPN / DMVPN / FlexVPN / N/A | IPSec / SSL VPN / DMVPN / FlexVPN | IPSec / SSL VPN / DMVPN / FlexVPN | IPSec / SSL VPN / GRE / DMVPN / FlexVPN |
| WAN Configuration | Dual WAN | Dual WAN | Dual WAN | Dual WAN | Dual WAN |
| WAN Ports | 2 WAN | Modular WAN | 2 WAN Ports | Modular WAN | Modular WAN |
| Weight | 10 lbs | N/A | N/A | 11 lbs | N/A |
| Wi-Fi Standard | N/A | N/A | N/A | N/A | N/A |
| Width | 17.6 inches | N/A | N/A | 17.5 inches | N/A |
| Wireless Support | No | No | No | No | No |
Reviews & Ratings
D
Daniel Whitmore
4
Stable routing with security enabled. Setup was smooth and day to day management is straightforward.
R
Robert Ellison
5
Good balance of performance and cost. Works reliably for branch connectivity.
J
James Thornton
3
Cisco reliability with useful AX features. No issues in production.
A
Andrew Collins
4
Meets expectations for secure branch routing. Consistent uptime.
Questions & Answers
What is the Cisco ISR 4221 AX Bundle w/APP, SEC lic?
The Cisco ISR 4221 AX Bundle w/APP, SEC lic (SKU ISR4221-AX/K9) is a fixed-port integrated services router with Cisco IOS XE, application-hosting capabilities, and an advanced Security license for firewall, IPS, AMP, URL filtering, and VPN encryption.
What hardware specifications does the ISR 4221 AX include?
The ISR 4221 AX features two Gigabit Ethernet ports, USB and console ports, 4 GB DRAM, 4 GB flash memory, an integrated Application Hosting module, and supports up to 50 Mbps aggregated WAN throughput in a compact desktop or rack-mountable design.
What throughput and performance can I expect?
With the AX Bundle and SEC license enabled, the ISR 4221 delivers up to 50 Mbps of aggregate WAN throughput, hardware-accelerated AES-256 encryption, and consistent performance under full security-service load.
Which security features are provided by the SEC license?
The Security (SEC) license includes Cisco IOS XE Firewall, Next-Generation Intrusion Prevention (NGIPS), Advanced Malware Protection (AMP), URL Filtering, and site-to-site IPsec VPN with AES-256 encryption.