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Cisco ISR 4221X delivers reliable routing performance with 2GE and 2NIM. Stable UC and network operations for small to medium offices.
ISR4221X/K9
Cisco ISR 4221 (2GE,2NIM,8G FLASH,8G DRAM,IPB)
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Name:
ISR4221X/K9
- Description:
- Cisco ISR 4221 (2GE,2NIM,8G FLASH,8G DRAM,IPB)
- Rating:
Added to cart 28 times recently
- Availability:
In stock - Ready to Ship
- Brand:
- Cisco
- GTIN:
- 818254519984
- Condition:
- Warranty:
- 3
- List Price:
$2,425.00
- Price:
$1,944.0019.8% off
Quantity:
1
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ISR4221X/K9 Overview
ISR4221X/K9 is a fixed-architecture enterprise router that offers robust performance with integrated services such as voice, video, and WAN optimization. It features versatile power options including AC, DC, and redundant power supplies, while providing dual WAN and four LAN interfaces with 10/100/1000 Ethernet technology for reliable connectivity and integrated VPN features like IPSec, SSL VPN, DMVPN, and FlexVPN.
ISR4221X/K9 delivers high availability with modular capabilities through two expansion slots for EHWIC/NIM modules and built-in firewall protection, ensuring secure routing and advanced QoS features. Designed for business branch offices and remote sites, it supports a range of routing protocols along with remote management via SSH, Telnet, and SNMP, making it ideal for modern, high-demand network environments.
ISR4221X/K9 price is $1,944.00, a 19.8% saving from the Cisco list price of $2,425.00. ISR4221X/K9 is in stock and available for next-day dispatch. (terms applied)
Request bulk order quote for ISR4221X/K9 for additional pricing. Browse the full Router Isr 4000 series or explore all Cisco products.
ISR4221X/K9 Specifications
- Product Type
- Enterprise Router
- VPN Support
- IPSec / SSL VPN / DMVPN / FlexVPN
- Power Source
- AC Power Supply / DC Power Supply / Redundant
- Routing Protocols
- OSPF / BGP / EIGRP / RIP / Static Routing
- Broadband
- N/A
- Architecture
- Fixed
- WAN Configuration
- Dual WAN
- WAN Ports
- 2 WAN
- LAN Ports
- 4 LAN Ports
- Ethernet Technology
- 10/100/1000
- Wi-Fi Standard
- N/A
- Connectivity Type
- Wired
- Network Protocols
- IPv4 / IPv6
- Remote Management
- SSH / Telnet / SNMP
- Compliance Standards
- FCC / CE / RoHS
- Wireless Support
- No
- Speed/Capacity
- Gigabit
- Firewall Features
- Yes
- Features
- VPN / Firewall / IPv6 Compatible
- Use Case
- Business
- Management
- Managed
- Form Factor
- Desktop
- Integrated Services
- Voice / Video / WAN Optimization
- High Availability Support
- Supported
- Safety
- UL / cUL
- EMC
- EN 55032 / EN 55024
- Telecom
- ITU-T
- Throughput Capacity
- 300 Mbps
- QoS Features
- Supported
- Built-in Security Features
- Firewall / Intrusion Prevention / Malware Protection
- Expansion Slots
- EHWIC / NIM
- Modular Slots Available
- 2 Slots
- Stacking Capability
- No
- 5G Support
- No
- Memory
- 4 GB
- Flash Memory
- 256 MB
- Interface Ports
- RJ-45
- Power
- 65W
- Device Type
- Router
- Product Name
- Cisco ISR 4221 Integrated Services Router
- Height
- N/A
- Width
- N/A
- Depth
- N/A
- Weight
- N/A
ISR4221X/K9 Use Case
Secure SD-WAN Deployment for Distributed Retail Branches
In a nationwide retail chain operating 200+ stores, the Cisco ISR 4221 (2GE,2NIM,8G FLASH,8G DRAM,IPB) delivers integrated SD-WAN, hardware-accelerated encryption, and dual-uplink failover to support POS transactions and high-definition video surveillance. Benefit: Achieve 25% lower WAN costs, 99.9% uptime SLA, and centralized policy enforcement for accelerated store rollout.
IoT Edge Aggregation and Zero-Trust Segmentation in Smart Manufacturing
At an automotive production facility deploying 1,000+ Modbus/TCP and OPC-UA sensors, the ISR 4221X/K9 functions as an industrial IoT gateway—aggregating edge data, enforcing ACL-based microsegmentation, and forwarding encrypted streams via IPsec VPN to cloud analytics. Benefit: Boost production visibility by 40%, enforce device isolation with zero-trust security, and streamline OT network administration.
Multi-Cloud Connectivity with Zero-Touch Provisioning for Financial Services
A global financial institution uses Cisco ISR 4221 (IP Base) with integrated NIM slots and Cisco DNA Center orchestration to establish automated, secure links between branch offices, AWS, Azure and private data centers. Benefit: Reduce branch deployment time by 60%, maintain a consistent security posture across clouds, and accelerate compliance audits with unified visibility.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table
 ISR4221X/K9 |  ISR4331-AX/K9 |  ISR4351-VSEC/K9 |  C1-CISCO4321/K9 |  ISR4451-X-AX/K9 | |
|---|---|---|---|---|---|
| 5G Support | No | No | No | No | No |
| Architecture | Fixed | Fixed / Modular | Modular | Modular | Modular |
| Broadband | N/A | N/A | N/A | N/A | N/A |
| Built-in Security Features | Firewall / Intrusion Prevention / Malware Protection | Firewall / Intrusion Prevention / Malware Protection | Firewall / Intrusion Prevention / Malware Protection | Firewall / Intrusion Prevention | Firewall / Intrusion Prevention |
| Compliance Standards | FCC / CE / RoHS | FCC / CE / UL | FCC / CE | FCC / CE | FCC / CE |
| Connectivity Type | Wired | Wired | Wired | Wired | Wired |
| Depth | N/A | N/A | 18.1 inches | 20 inches | 16.90 inches |
| Device Type | Router | Router | Router | Router | Router |
| EMC | EN 55032 / EN 55024 | FCC / CE | N/A | N/A | FCC / CE |
| Ethernet Technology | 10/100/1000 | 10/100/1000 | 10/100/1000 | 10/100/1000 | 10/100/1000 |
| Expansion Slots | EHWIC / NIM | EHWIC / NIM | EHWIC / NIM | NIM / EHWIC | EHWIC / NIM |
| Features | VPN / Firewall / IPv6 Compatible | VPN / IPv6 Compatible / Firewall / WAN Optimization / Voice / Video | VPN / IPv6 Compatible / Firewall / MPLS | VPN / VoIP / IPv6 Compatible / Firewall / WAN Optimization | VPN / VoIP / IPv6 Compatible / Firewall / MPLS / Syslog |
| Firewall Features | Yes | Yes | Yes | Yes | Yes |
| Flash Memory | 256 MB | 512 MB | 512 MB | 512 MB | 512 MB |
| Form Factor | Desktop | Rack-mount | Rack-mount | Rack-mount | Rack-mount |
| Height | N/A | N/A | 1.73 inches | 1.75 inches | 1.75 inches |
| High Availability Support | Supported | Supported | Supported | Supported | Supported |
| Integrated Services | Voice / Video / WAN Optimization | Voice / Video / WAN Optimization | Voice / Security | Voice / Video / WAN Optimization | Voice / Video |
| Interface Ports | RJ-45 | RJ-45 / SFP | RJ-45 / SFP | RJ-45 / SFP | RJ-45 / SFP |
| LAN Ports | 4 LAN Ports | 4 LAN Ports | 4 LAN Ports | Modular LAN | 4 LAN Ports |
| Management | Managed | Managed | Managed | Managed | Managed |
| Memory | 4 GB | 4 GB | 4 GB | 1 GB | 4 GB |
| Modular Slots Available | 2 Slots | 3+ Slots | 2 Slots | 2 Slots | 3 Slots |
| Network Protocols | IPv4 / IPv6 | IPv4 / IPv6 | IPv4 / IPv6 | IPv4, IPv6 | IPv4 / IPv6 / MPLS |
| Power | 65W | 65 Watts | 350 W | 110 W | 350W |
| Power Source | AC Power Supply / DC Power Supply / Redundant | AC Power Supply | AC Power Supply / Redundant | AC Power Supply with Redundant Options | AC Power Supply / Redundant |
| Product Name | Cisco ISR 4221 Integrated Services Router | Cisco ISR4331-AX/K9 | Cisco ISR4351-VSEC/K9 | Cisco 4321 Integrated Services Router (C1-CISCO4321/K9) | Cisco ISR4451-X-AX/K9 |
| Product Type | Enterprise Router | Enterprise Router | Enterprise Router | Enterprise Router | Enterprise Router |
| QoS Features | Supported | Supported | Supported | Supported | Supported |
| Remote Management | SSH / Telnet / SNMP | SSH / Telnet / SNMP | CLI / SNMP / NetConf | SSH / Telnet / SNMP | Cisco IOS XE CLI / SNMP / NetConf |
| Routing Protocols | OSPF / BGP / EIGRP / RIP / Static Routing | OSPF / BGP / EIGRP / MPLS / RIP / Static Routing | OSPF / BGP / EIGRP / RIP / Static Routing | OSPF / BGP / EIGRP / RIP / Static Routing | OSPF / BGP / EIGRP / RIP / Static Routing |
| Safety | UL / cUL | UL / IEC | N/A | N/A | UL / CSA |
| Speed/Capacity | Gigabit | Gigabit | Gigabit | Gigabit | Gigabit |
| Stacking Capability | No | No | No | No | No |
| Telecom | ITU-T | TIA/EIA | N/A | N/A | N/A |
| Throughput Capacity | 300 Mbps | 0.15 Gbps | 0.15 Gbps | 0.15 Gbps | 2 Gbps |
| Use Case | Business | Enterprise / Branch | Enterprise | Enterprise | Enterprise |
| VPN Support | IPSec / SSL VPN / DMVPN / FlexVPN | IPSec / SSL VPN / DMVPN / FlexVPN | IPSec / SSL VPN / DMVPN / FlexVPN | IPSec / SSL VPN / DMVPN / FlexVPN | IPSec / DMVPN / FlexVPN / N/A |
| WAN Configuration | Dual WAN | Dual WAN | Dual WAN | Dual WAN | Dual WAN |
| WAN Ports | 2 WAN | 2 WAN | 2 WAN | 2 WAN | 2 WAN |
| Weight | N/A | N/A | 16.5 lbs | 14 lbs | 17.6 lbs |
| Wi-Fi Standard | N/A | N/A | N/A | N/A | N/A |
| Width | N/A | N/A | 17.2 inches | 17.5 inches | 17.32 inches |
| Wireless Support | No | No | No | No | No |
Reviews & Ratings
L
Liam Scott
4
Durable and predictable. Easy to configure and manage while maintaining consistent voice and data performance.
C
Chloe Richardson
5
High-performing and efficient. Supports IP routing and UC workloads reliably for branch deployments.
N
Noah Bennett
3
Reliable Cisco solution. Maintains secure voice, UC, and network services with minimal downtime.
A
Ava Coleman
4
Strong and efficient. Ideal for small to medium offices requiring stable routing and UC operations.
Questions & Answers
What is the Cisco ISR 4221 (ISR4221X/K9)?
The Cisco ISR 4221 is a compact branch router offering dual Gigabit Ethernet ports, two NIM slots, 8 GB flash, 8 GB DRAM, and integrated IP Base software for secure and reliable WAN connectivity.
What key performance specifications does the ISR 4221 deliver?
The ISR 4221 delivers up to 50 Mbps tunnel throughput, 25 Mbps IPsec throughput, 20 Kpps forwarding rate, and supports up to 1 Gbps performance with boost licensing.
Which network interfaces are available on the ISR 4221?
The ISR 4221 provides two fixed Gigabit Ethernet ports and two NIM slots that support a variety of interfaces including additional Ethernet, T1/E1, and 3G/4G modules.
How much memory and storage does the ISR 4221 support?
The router ships with 8 GB of DRAM and 8 GB of onboard flash, and supports up to 16 GB of flash storage via an optional SD card.