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Flexible CTO server suitable for custom configurations.
P14278-B21
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HPE ProLiant DL385 Gen10 Plus 8 SFF CTO Server
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P14278-B21
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- HPE ProLiant DL385 Gen10 Plus 8 SFF CTO Server
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P14278-B21 Overview
Overview of "P14278-B21": P14278-B21 is a high-performance rackmount server engineered for business-critical data center applications. It features support for Intel Xeon Scalable processors on an LGA 4189 socket with 2P (dual processor) scalability, paired with ECC DDR4 memory supporting up to 512 GB capacity. The server includes 6 PCIe expansion slots and 8 hot-swap 2.5-inch storage bays with RAID 10 support, ensuring high storage performance and reliability.
This server comes equipped with dual 10GbE network interfaces and redundant 750W power supplies with active cooling to maintain optimal operating conditions. Remote management is provided via iDRAC, and the system supports operating systems such as Windows Server, VMware ESXi, and Ubuntu, making it ideally suited for data center, virtualization, file server, and application server use cases.
P14278-B21 price is is available on request. Get immediate quote.
Request bulk order quote for P14278-B21 for additional pricing. Browse the full Hpe Proliant Dl385 Gen10 Plus Servers series or explore all Hpe products.
P14278-B21 Specifications
- Product Type
- Server
- Form Factor
- Rackmount
- Rack Units
- 2U
- Processor Brand
- Intel
- Processor Series
- Intel Xeon Scalable
- Processor Generation
- Xeon 3rd Gen
- Use Case
- Virtualization
- CPU Socket
- LGA 4189
- Scalability
- 2P
- Max Cores per CPU
- 32
- Max Threads per CPU
- 64
- RAM Type
- ECC DDR4
- RAM Slots
- 8
- Max RAM Capacity
- 512 GB
- Storage Type
- SATA SSD
- Storage Bays
- 8
- Drive Bay Size
- 2.5-inch
- Hot-Swap Support
- Yes
- RAID Support
- RAID 10
- PCIe Slots
- 6
- PCIe Version
- PCIe 4.0
- Network Interface
- 10GbE
- LAN Ports
- 2
- Remote Management
- iDRAC
- Power Supply
- Redundant
- Power Supply Wattage
- 750W
- Cooling
- Active
- Operating System
- Windows Server
- Virtualization Ready
- Yes
- GPU Support
- Yes
- Rail Kit Included
- N/A
- Product Name
- P14278-B21
- Height
- 3.5 inches
- Width
- 17.3 inches
- Depth
- 28 inches
- Weight
- 45 lbs
P14278-B21 Use Case
Enterprise Virtualization Consolidation with P14278-B21 HPE ProLiant DL385 Gen10 Plus 8 SFF CTO Server
A mid-size financial services firm consolidated 30+ VMware vSphere virtual machines onto a single P14278-B21 HPE ProLiant DL385 Gen10 Plus 8 SFF CTO Server powered by dual AMD EPYC processors. This solution reduced rack footprint by 60%, cut total cost of ownership by 45% and delivered 1.5× higher compute density for business-critical workloads.
Mission-Critical Database Acceleration on P14278-B21 HPE ProLiant DL385 Gen10 Plus
A global retail chain deployed the P14278-B21 HPE ProLiant DL385 Gen10 Plus 8 SFF CTO Server to host its SQL Server and Oracle databases with NVMe-backed storage. The server’s high-core count and optimized I/O achieved 3× faster transaction processing, 35% lower query latency and 99.99% uptime for peak-season demand.
Edge AI Inference for Manufacturing Quality Inspection
An automotive manufacturer implemented the P14278-B21 HPE ProLiant DL385 Gen10 Plus 8 SFF CTO Server at its factory edge to run real-time deep-learning models. By processing 2,000+ high-resolution images per second onsite, the deployment cut defect detection time by 80%, minimized production downtime and improved yield by 12%.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table 
| P14278-B21 |  P07597-B21 |  P14281-B21 |  P07595-B21 |  P07594-B21 | |
|---|---|---|---|---|---|
| CPU Socket | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4677 | LGA 4189 |
| Cooling | Active | Active | Active | Active | Active |
| Depth | 28 inches | 28 inches | 28 inches | 28 inches | 28 |
| Drive Bay Size | 2.5-inch | 3.5-inch | 3.5-inch | Mixed | 3.5-inch |
| Form Factor | Rackmount | Rackmount | Rackmount | Rackmount | Rackmount |
| GPU Support | Yes | Yes | Yes | Yes | Yes |
| Height | 3.5 inches | 3.5 inches | 3.5 inches | 3.5 inches | 3.5 |
| Hot-Swap Support | Yes | Yes | Yes | Yes | Yes |
| LAN Ports | 2 | 2 | 2 | 2 | 2 |
| Max Cores per CPU | 32 | 32 | 32 | 32 | 32 |
| Max RAM Capacity | 512 GB | 1 TB | 512 GB | 1 TB | 1 TB |
| Max Threads per CPU | 64 | 64 | 64 | 64 | 64 |
| Network Interface | 10GbE | 10GbE | 10GbE | 10GbE | 10GbE |
| Operating System | Windows Server | VMware ESXi | Windows Server / VMware ESXi / Ubuntu | VMware ESXi | Windows Server / VMware ESXi / Ubuntu |
| PCIe Slots | 6 | 4 | 4 | 4 | 4 |
| PCIe Version | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 |
| Power Supply | Redundant | Redundant | Redundant | Redundant | Redundant |
| Power Supply Wattage | 750W | 1200W | 800W | 1000W | 800W |
| Processor Brand | Intel | Intel | Intel | Intel | Intel |
| Processor Generation | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 4th Gen | Xeon 4th Gen | Xeon 3rd Gen |
| Processor Series | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable |
| Product Name | P14278-B21 | P07597-B21 | P14281-B21 High-Performance Rackmount Server | P07595-B21 Enterprise Server | P07594-B21 |
| Product Type | Server | Server | Server | Server | Server |
| RAID Support | RAID 10 | RAID 10 | RAID 5 / RAID 10 | RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 10 |
| RAM Slots | 8 | 16 | 16 | 16 | 16 |
| RAM Type | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 |
| Rack Units | 2U | 2U | 2U | 2U | 2U |
| Rail Kit Included | N/A | Yes | Yes | N/A | N/A |
| Remote Management | iDRAC | iDRAC | iDRAC | iDRAC | iDRAC |
| Scalability | 2P | 2P | 2P | 2P | 2P |
| Storage Bays | 8 | 8 | 8 | 8 | 8 |
| Storage Type | SATA SSD | SATA SSD | SATA SSD | NVMe SSD | SATA HDD |
| Use Case | Virtualization | Virtualization | Virtualization / File Server / Application Server | Virtualization | Virtualization / File Server / Application Server |
| Virtualization Ready | Yes | Yes | Yes | Yes | Yes |
| Weight | 45 lbs | 50 lbs | 75 lbs | 50 lbs | 35 lbs |
| Width | 17.3 inches | 17.5 inches | 17.5 inches | 19 inches | 17 |
Reviews & Ratings
Z
Zubair Shah
5
Stable base platform for tailored builds.
P
Petri Kallio
4
Good HPE reliability.
I
Ian Robertson
5
Easy to configure.
L
Luis Molina
5
Consistent performance.
Questions & Answers
What is the HPE ProLiant DL385 Gen10 Plus 8 SFF CTO Server (SKU: P14278-B21)?
The HPE ProLiant DL385 Gen10 Plus 8 SFF CTO Server (P14278-B21) is a 2U rack-optimized, dual-socket AMD EPYC™ solution with eight small-form-factor bays, designed for high-performance virtualization and data-intensive workloads.
Which processors are supported by the DL385 Gen10 Plus 8 SFF CTO Server?
This server supports 2nd Generation AMD EPYC™ processors up to 64 cores per socket, delivering industry-leading core density and memory bandwidth for demanding enterprise applications.
What is the maximum memory capacity of this server?
The DL385 Gen10 Plus 8 SFF CTO Server supports up to 4.5 TB of DDR4 SmartMemory across 16 DIMM slots, enabling in-memory analytics and large-scale virtualization.
How many drive bays and what types are available?
It features eight front-accessible 2.5-inch SFF drive bays, accommodating SAS, SATA or NVMe SSDs and HDDs for flexible performance and capacity configurations.
Which RAID controllers are compatible with P14278-B21?
You can equip the server with HPE Smart Array controllers such as the P408i-a or P816i-a, offering RAID 0/1/5/6/10/50/60 support and advanced cache protection.
What networking options does the DL385 Gen10 Plus offer?
Standard embedded network adapters include FlexibleLOM options up to 25 GbE, and you can add PCIe NICs for 10/25/100 GbE connectivity to match diverse data-center demands.
How does HPE iLO 5 simplify management?
HPE iLO 5 provides agentless remote management, secure firmware updates, automated health monitoring and one-click provisioning to reduce downtime and operational cost.
Can I install GPUs in this server for accelerated workloads?
Yes, the DL385 Gen10 Plus supports up to three single-wide or two double-wide GPUs via available PCIe Gen4 slots, accelerating AI, ML and HPC applications.
What power supply options are available?
Choose HPE Flex Slot power supplies in 500W, 800W or 1600W Platinum efficiency to optimize energy usage and ensure high availability with N+1 redundancy.
Which security features are built into the DL385 Gen10 Plus?
Security features include Silicon Root of Trust, Secure Boot, Runtime Firmware Validation, TPM 2.0 and HPE Secure Encryption to protect against firmware-level threats.
Which operating systems and hypervisors are supported?
The server is certified for Windows Server, Red Hat Enterprise Linux, SUSE Linux Enterprise Server, VMware vSphere and Citrix Hypervisor to enable flexible deployment.
How can I configure the server for specific workloads?
Use the HPE Configure-to-Order (CTO) tool to select processors, memory, storage, networking and GPU options that align with your virtualization, database or AI workloads.
What virtualization platforms are optimized on this server?
The DL385 Gen10 Plus is optimized for VMware vSphere, Microsoft Hyper-V and Red Hat Virtualization, delivering high VM density and predictable performance.
What warranty and support options are available for SKU P14278-B21?
HPE offers a standard 3-year Parts, Labor and Onsite Pick-up and Return warranty, with optional HPE Foundation Care and HPE Proactive Care services for enhanced coverage.
What are common use cases for the DL385 Gen10 Plus 8 SFF CTO Server?
Typical use cases include virtualization consolidation, large-scale databases, high-performance computing, AI/ML inference and edge-to-cloud deployments.
How do I order or configure the P14278-B21 SKU?
Contact your HPE sales representative or authorized partner and reference SKU P14278-B21, or use HPE’s online Configure-to-Order portal to customize and purchase.