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High density SFF server with strong performance.
P14281-B21
HPE ProLiant DL385 Gen10 Plus 8LFF CTO Server
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P14281-B21
- Description:
- HPE ProLiant DL385 Gen10 Plus 8LFF CTO Server
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P14281-B21 Overview
P14281-B21 is a high-performance rackmount server engineered with support for Intel Xeon Scalable processors, utilizing the LGA 4189 socket and offering 2P scalability. It is built with ECC DDR4 memory, delivering up to 512 GB across 16 slots to ensure reliable performance in demanding environments.
The server features four PCIe 4.0 expansion slots, eight 3.5-inch hot-swap storage bays configured for SATA SSDs with RAID 5 and RAID 10 support, and dual 10GbE network interfaces. It is equipped with redundant 800W power supplies, active cooling, iDRAC remote management, and supports Windows Server, VMware ESXi, and Ubuntu, making it ideal for data center operations, virtualization, file serving, and application hosting.
P14281-B21 price is is available on request. Get immediate quote.
Request bulk order quote for P14281-B21 for additional pricing. Browse the full Hpe Proliant Dl385 Gen10 Plus Servers series or explore all Hpe products.
P14281-B21 Specifications
- Product Type
- Server
- Form Factor
- Rackmount
- Rack Units
- 2U
- Processor Brand
- Intel
- Processor Series
- Intel Xeon Scalable
- Processor Generation
- Xeon 4th Gen
- Use Case
- Virtualization / File Server / Application Server
- CPU Socket
- LGA 4189
- Scalability
- 2P
- Max Cores per CPU
- 32
- Max Threads per CPU
- 64
- RAM Type
- ECC DDR4
- RAM Slots
- 16
- Max RAM Capacity
- 512 GB
- Storage Type
- SATA SSD
- Storage Bays
- 8
- Drive Bay Size
- 3.5-inch
- Hot-Swap Support
- Yes
- RAID Support
- RAID 5 / RAID 10
- PCIe Slots
- 4
- PCIe Version
- PCIe 4.0
- Network Interface
- 10GbE
- LAN Ports
- 2
- Remote Management
- iDRAC
- Power Supply
- Redundant
- Power Supply Wattage
- 800W
- Cooling
- Active
- Operating System
- Windows Server / VMware ESXi / Ubuntu
- Virtualization Ready
- Yes
- GPU Support
- Yes
- Rail Kit Included
- Yes
- Product Name
- P14281-B21 High-Performance Rackmount Server
- Height
- 3.5 inches
- Width
- 17.5 inches
- Depth
- 28 inches
- Weight
- 75 lbs
P14281-B21 Use Case
Enterprise Virtualization and Server Consolidation
A global retail chain consolidates 200 physical servers onto 20 P14281-B21-HPE ProLiant DL385 Gen10 Plus 8LFF CTO Servers running VMware vSphere to host inventory, POS and ERP applications. Benefit: achieves a 60% reduction in rack space, a 40% decrease in total cost of ownership, and maintains 99.99% application uptime.
High-Performance In-Memory Database for SAP HANA
A manufacturing firm deploys the P14281-B21-HPE ProLiant DL385 Gen10 Plus 8LFF CTO Server to power SAP HANA in-memory analytics for real-time production monitoring and quality control. Benefit: delivers sub-second query response, accelerates data load times by 5×, and enables instant decision-making on the shop floor.
AI/ML Inference and Edge Analytics
A telematics provider installs P14281-B21-HPE ProLiant DL385 Gen10 Plus 8LFF CTO Servers at regional edge sites to run machine learning inference on streaming sensor data. Benefit: improves inference throughput by 3×, cuts latency by 20%, and provides real-time insights for predictive maintenance and operational efficiency.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table
 P14281-B21 |  P07598-B21 |  P07596-B21 |  P07597-B21 |  P14280-B21 | |
|---|---|---|---|---|---|
| CPU Socket | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 |
| Cooling | Active | Active | Active | Active | Active |
| Depth | 28 inches | 28 inches | 28 | 28 inches | 28.0 inches |
| Drive Bay Size | 3.5-inch | Mixed | Mixed | 3.5-inch | 3.5-inch |
| Form Factor | Rackmount | Rackmount | Rackmount | Rackmount | Rackmount |
| GPU Support | Yes | No | Yes | Yes | No |
| Height | 3.5 inches | 3.5 inches | 3.5 | 3.5 inches | 3.5 inches |
| Hot-Swap Support | Yes | Yes | Yes | Yes | Yes |
| LAN Ports | 2 | 4 | 2 | 2 | 2 |
| Max Cores per CPU | 32 | 32 | 32 | 32 | 32 |
| Max RAM Capacity | 512 GB | 1 TB | 1 TB | 1 TB | 512 GB |
| Max Threads per CPU | 64 | 64 | 64 | 64 | 64 |
| Network Interface | 10GbE | 1GbE | 10GbE | 10GbE | 1GbE |
| Operating System | Windows Server / VMware ESXi / Ubuntu | Windows Server / VMware ESXi / RHEL | VMware ESXi | VMware ESXi | Windows Server |
| PCIe Slots | 4 | 6 | 4 | 4 | 4 |
| PCIe Version | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 |
| Power Supply | Redundant | Redundant | Redundant | Redundant | Redundant |
| Power Supply Wattage | 800W | 800W | 1200W | 1200W | 750W |
| Processor Brand | Intel | Intel | Intel | Intel | Intel |
| Processor Generation | Xeon 4th Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen |
| Processor Series | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable |
| Product Name | P14281-B21 High-Performance Rackmount Server | P07598-B21 High Performance Rackmount Server | P07596-B21 Enterprise Server | P07597-B21 | P14280-B21 |
| Product Type | Server | Server | Server | Server | Server |
| RAID Support | RAID 5 / RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10 | RAID 0 / RAID 1 / RAID 10 | RAID 10 | RAID 10 |
| RAM Slots | 16 | 16 | 16 | 16 | 8 |
| RAM Type | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 |
| Rack Units | 2U | 2U | 2U | 2U | 2U |
| Rail Kit Included | Yes | No | Yes | Yes | N/A |
| Remote Management | iDRAC | iDRAC | iDRAC | iDRAC | iDRAC |
| Scalability | 2P | 2P | 2P | 2P | 2P |
| Storage Bays | 8 | 8 | 8 | 8 | 10 |
| Storage Type | SATA SSD | SATA SSD | NVMe SSD | SATA SSD | SATA HDD |
| Use Case | Virtualization / File Server / Application Server | Virtualization | Virtualization | Virtualization | Virtualization |
| Virtualization Ready | Yes | Yes | Yes | Yes | Yes |
| Weight | 75 lbs | 45 lbs | 75 | 50 lbs | 50 lbs |
| Width | 17.5 inches | 17.5 inches | 19 | 17.5 inches | 17.2 inches |
Reviews & Ratings
W
Waqas Latif
4
Handles virtualization workloads well.
K
Knut Andersen
5
Good scalability options.
M
Matthew Rhodes
3
Stable production use.
F
Felipe Torres
4
Meets enterprise requirements.
Questions & Answers
What are the key specifications of the HPE ProLiant DL385 Gen10 Plus 8LFF CTO Server?
The HPE ProLiant DL385 Gen10 Plus 8LFF CTO Server is a 2U rack-mount system featuring dual AMD EPYC 7002/7003 processors, up to 3 TB of DDR4-3200 ECC memory across 16 DIMM slots, eight 3.5″ LFF drive bays, integrated HPE iLO 5 management, FlexibleLOM networking, and fully customizable CTO options.
Which processors are supported by this server?
This server supports dual AMD EPYC 7002 and 7003 series CPUs with up to 64 cores per socket, delivering high multi-thread performance for demanding enterprise applications.
What memory configurations are available?
The system accepts up to 3 TB of DDR4-3200 ECC RDIMM or LRDIMM memory across 16 DIMM slots, offering data integrity and speeds up to 3200 MT/s for memory-intensive workloads.
How much internal storage can it house?
It accommodates eight 3.5″ LFF SAS/SATA or NVMe drives for up to 96 TB of raw capacity, with optional M.2 boot drives and HPE SmartArray controllers for additional flexibility.