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P14281-B21
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- HPE ProLiant DL385 Gen10 Plus 8LFF CTO Server
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Return any product within 14 days of delivery if it doesn’t meet your technical or operational needs.
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All equipment includes a 30-day replacement warranty. If something goes wrong, we’ll repair or swap it — fast.
Replacements shipped in 10 days or less.
Once your return is inspected and approved, we dispatch the replacement promptly to keep your operations moving.
RMA protocol keeps it smooth.
Just ensure all accessories and original packaging are intact — we’ll take care of the technical validation.
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P14281-B21 Overview
P14281-B21 is a high-performance rackmount server engineered with support for Intel Xeon Scalable processors, utilizing the LGA 4189 socket and offering 2P scalability. It is built with ECC DDR4 memory, delivering up to 512 GB across 16 slots to ensure reliable performance in demanding environments.
The server features four PCIe 4.0 expansion slots, eight 3.5-inch hot-swap storage bays configured for SATA SSDs with RAID 5 and RAID 10 support, and dual 10GbE network interfaces. It is equipped with redundant 800W power supplies, active cooling, iDRAC remote management, and supports Windows Server, VMware ESXi, and Ubuntu, making it ideal for data center operations, virtualization, file serving, and application hosting.
What is the price of P14281-B21?
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P14281-B21 Specifications
| Product Type | Server |
| Form Factor | Rackmount |
| Rack Units | 2U |
| Processor Brand | Intel |
| Processor Series | Intel Xeon Scalable |
| Processor Generation | Xeon 4th Gen |
| Use Case | Virtualization / File Server / Application Server |
| CPU Socket | LGA 4189 |
| Scalability | 2P |
| Max Cores Per CPU | 32 |
| Max Threads Per CPU | 64 |
| RAM Type | ECC DDR4 |
| RAM Slots | 16 |
| Max RAM Capacity | 512 GB |
| Storage Type | SATA SSD |
| Storage Bays | 8 |
| Drive Bay Size | 3.5-inch |
| Hot-Swap Support | Yes |
| RAID Support | RAID 5 / RAID 10 |
| PCIe Slots | 4 |
| PCIe Version | PCIe 4.0 |
| Network Interface | 10GbE |
| LAN Ports | 2 |
| Remote Management | iDRAC |
| Power Supply | Redundant |
| Power Supply Wattage | 800W |
| Cooling | Active |
| Operating System | Windows Server / VMware ESXi / Ubuntu |
| Virtualization Ready | Yes |
| GPU Support | Yes |
| Rail Kit Included | Yes |
| Product Name | P14281-B21 High-Performance Rackmount Server |
| Height | 3.5 inches |
| Width | 17.5 inches |
| Depth | 28 inches |
| Weight | 75 lbs |
P14281-B21 Use Case
Enterprise Virtualization and Server Consolidation
A global retail chain consolidates 200 physical servers onto 20 P14281-B21-HPE ProLiant DL385 Gen10 Plus 8LFF CTO Servers running VMware vSphere to host inventory, POS and ERP applications. Benefit: achieves a 60% reduction in rack space, a 40% decrease in total cost of ownership, and maintains 99.99% application uptime.
High-Performance In-Memory Database for SAP HANA
A manufacturing firm deploys the P14281-B21-HPE ProLiant DL385 Gen10 Plus 8LFF CTO Server to power SAP HANA in-memory analytics for real-time production monitoring and quality control. Benefit: delivers sub-second query response, accelerates data load times by 5×, and enables instant decision-making on the shop floor.
AI/ML Inference and Edge Analytics
A telematics provider installs P14281-B21-HPE ProLiant DL385 Gen10 Plus 8LFF CTO Servers at regional edge sites to run machine learning inference on streaming sensor data. Benefit: improves inference throughput by 3×, cuts latency by 20%, and provides real-time insights for predictive maintenance and operational efficiency.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table
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| Cooling | Active | Active | Active | Active | Active |
| CPU Socket | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 |
| Depth | 28 | 28 inches | 28 inches | 28.0 inches | 28 inches |
| Drive Bay Size | Mixed | Mixed | 3.5-inch | 3.5-inch | 3.5-inch |
| Form Factor | Rackmount | Rackmount | Rackmount | Rackmount | Rackmount |
| GPU Support | Yes | No | Yes | No | Yes |
| Height | 3.5 | 3.5 inches | 3.5 inches | 3.5 inches | 3.5 inches |
| Hot-Swap Support | Yes | Yes | Yes | Yes | Yes |
| LAN Ports | 2 | 4 | 2 | 2 | 2 |
| Max Cores per CPU | 32 | 32 | 32 | 32 | 32 |
| Max RAM Capacity | 1 TB | 1 TB | 1 TB | 512 GB | 512 GB |
| Max Threads per CPU | 64 | 64 | 64 | 64 | 64 |
| Network Interface | 10GbE | 1GbE | 10GbE | 1GbE | 10GbE |
| Operating System | VMware ESXi | Windows Server / VMware ESXi / RHEL | VMware ESXi | Windows Server | Windows Server / VMware ESXi / Ubuntu |
| PCIe Slots | 4 | 6 | 4 | 4 | 4 |
| PCIe Version | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 |
| Power Supply | Redundant | Redundant | Redundant | Redundant | Redundant |
| Power Supply Wattage | 1200W | 800W | 1200W | 750W | 800W |
| Processor Brand | Intel | Intel | Intel | Intel | Intel |
| Processor Generation | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 4th Gen |
| Processor Series | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable |
| Product Name | P07596-B21 Enterprise Server | P07598-B21 High Performance Rackmount Server | P07597-B21 | P14280-B21 | P14281-B21 High-Performance Rackmount Server |
| Product Type | Server | Server | Server | Server | Server |
| Rack Units | 2U | 2U | 2U | 2U | 2U |
| RAID Support | RAID 0 / RAID 1 / RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10 | RAID 10 | RAID 10 | RAID 5 / RAID 10 |
| Rail Kit Included | Yes | No | Yes | N/A | Yes |
| RAM Slots | 16 | 16 | 16 | 8 | 16 |
| RAM Type | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 |
| Remote Management | iDRAC | iDRAC | iDRAC | iDRAC | iDRAC |
| Scalability | 2P | 2P | 2P | 2P | 2P |
| Storage Bays | 8 | 8 | 8 | 10 | 8 |
| Storage Type | NVMe SSD | SATA SSD | SATA SSD | SATA HDD | SATA SSD |
| Use Case | Virtualization | Virtualization | Virtualization | Virtualization | Virtualization / File Server / Application Server |
| Virtualization Ready | Yes | Yes | Yes | Yes | Yes |
| Weight | 75 | 45 lbs | 50 lbs | 50 lbs | 75 lbs |
| Width | 19 | 17.5 inches | 17.5 inches | 17.2 inches | 17.5 inches |
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Questions & Answers
Q
What are the key specifications of the HPE ProLiant DL385 Gen10 Plus 8LFF CTO Server?
A
The HPE ProLiant DL385 Gen10 Plus 8LFF CTO Server is a 2U rack-mount system featuring dual AMD EPYC 7002/7003 processors, up to 3 TB of DDR4-3200 ECC memory across 16 DIMM slots, eight 3.5″ LFF drive bays, integrated HPE iLO 5 management, FlexibleLOM networking, and fully customizable CTO options.
Q
Which processors are supported by this server?
A
This server supports dual AMD EPYC 7002 and 7003 series CPUs with up to 64 cores per socket, delivering high multi-thread performance for demanding enterprise applications.
Q
What memory configurations are available?
A
The system accepts up to 3 TB of DDR4-3200 ECC RDIMM or LRDIMM memory across 16 DIMM slots, offering data integrity and speeds up to 3200 MT/s for memory-intensive workloads.
Q
How much internal storage can it house?
A
It accommodates eight 3.5″ LFF SAS/SATA or NVMe drives for up to 96 TB of raw capacity, with optional M.2 boot drives and HPE SmartArray controllers for additional flexibility.
Q
What is the form factor of the DL385 Gen10 Plus 8LFF CTO Server?
A
The DL385 Gen10 Plus 8LFF CTO Server uses a 2U rack-mount form factor designed for high-density data center deployments.
Q
Which expansion slots does this server offer?
A
It provides three PCIe Gen4 slots and one FlexibleLOM slot, enabling high-speed I/O expansion and choice of networking or accelerator cards.
Q
What networking options are included?
A
The server supports HPE FlexibleLOM adapters for 1/10/25/40/100 GbE, plus onboard LOM options, delivering scalable bandwidth and low-latency connectivity.
Q
How does HPE iLO 5 enhance management?
A
Embedded HPE iLO 5 offers remote server provisioning, firmware lifecycle automation, health monitoring, power optimization, and advanced security features for streamlined operations.
Q
What power supplies are available for this server?
A
Redundant hot-plug HPE 500 W, 800 W, or 1 600 W Platinum-rated power supplies deliver up to 94% efficiency with power capping and load balancing.
Q
Which operating systems are supported?
A
HPE ProLiant DL385 Gen10 Plus is validated for Windows Server, VMware vSphere, Red Hat Enterprise Linux, SUSE Linux Enterprise Server, Ubuntu, and other HPE-certified OS platforms.
Q
Can this server be customized (CTO)?
A
Yes. The Configure-to-Order (CTO) process lets you tailor CPUs, memory, storage, networking, accelerator cards, and management modules to your specific workload requirements.
Q
What security features are integrated?
A
Key security features include HPE Silicon Root of Trust, Secure Boot, Secure Firmware Update, Runtime Firmware Validation, and TPM 2.0 to protect hardware and firmware integrity.
Q
Is this server optimized for virtualization workloads?
A
Yes. It is certified for VMware, Microsoft Hyper-V, Red Hat Virtualization, and offers advanced memory capacity, I/O bandwidth, and security for efficient VM density and performance.
Q
What warranty and support options are available?
A
Standard HPE Foundation Care provides a three-year, parts-only warranty. Upgrade options include 24×7 same-day response, Proactive Care, and HPE Tech Care for extended coverage.
Q
How does this server perform in enterprise environments?
A
With up to 4 million IOPS, up to 33% higher performance per rack unit versus previous generations, and industry-leading memory bandwidth, it excels in databases, analytics, VDI, and HPC workloads.
Q
How can I purchase or get a quote for SKU P14281-B21?
A
Contact your HPE sales representative or authorized reseller, or request an online quote through HPE’s storefront by referencing part number P14281-B21.