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Large storage capacity server fits our needs.
P14280-B21
HPE ProLiant DL385 Gen10 Plus 12 LFF CTO Server
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P14280-B21
- Description:
- HPE ProLiant DL385 Gen10 Plus 12 LFF CTO Server
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P14280-B21 Overview
P14280-B21 is a high-performance rackmount server engineered with support for Intel Xeon Scalable processors on an LGA 4189 socket, offering 2P CPU scalability to meet demanding workloads. It comes equipped with ECC DDR4 memory up to 512 GB across 8 slots, 4 PCIe 4.0 expansion slots, and 10 3.5-inch drive bays featuring hot-swap capability and RAID 10 support for reliable storage.
P14280-B21 also features dual redundant 750W power supplies and active cooling to maintain optimal operating temperatures in intensive data center environments. Integrated 1GbE network interfaces with 2 LAN ports, remote management via iDRAC, and official support for Windows Server and VMware ESXi make this server ideally suited for virtualization, file serving, and application hosting use cases.
P14280-B21 price is is available on request. Get immediate quote.
Request bulk order quote for P14280-B21 for additional pricing. Browse the full Hpe Proliant Dl385 Gen10 Plus Servers series or explore all Hpe products.
P14280-B21 Specifications
- Product Type
- Server
- Form Factor
- Rackmount
- Rack Units
- 2U
- Processor Brand
- Intel
- Processor Series
- Intel Xeon Scalable
- Processor Generation
- Xeon 3rd Gen
- Use Case
- Virtualization
- CPU Socket
- LGA 4189
- Scalability
- 2P
- Max Cores per CPU
- 32
- Max Threads per CPU
- 64
- RAM Type
- ECC DDR4
- RAM Slots
- 8
- Max RAM Capacity
- 512 GB
- Storage Type
- SATA HDD
- Storage Bays
- 10
- Drive Bay Size
- 3.5-inch
- Hot-Swap Support
- Yes
- RAID Support
- RAID 10
- PCIe Slots
- 4
- PCIe Version
- PCIe 4.0
- Network Interface
- 1GbE
- LAN Ports
- 2
- Remote Management
- iDRAC
- Power Supply
- Redundant
- Power Supply Wattage
- 750W
- Cooling
- Active
- Operating System
- Windows Server
- Virtualization Ready
- Yes
- GPU Support
- No
- Rail Kit Included
- N/A
- Product Name
- P14280-B21
- Height
- 3.5 inches
- Width
- 17.2 inches
- Depth
- 28.0 inches
- Weight
- 50 lbs
P14280-B21 Use Case
Enterprise Virtualization and Workload Consolidation
In a global enterprise data center, IT architects deploy the P14280-B21-HPE ProLiant DL385 Gen10 Plus 12 LFF CTO Server to run VMware vSphere and Hyper-V clusters. Leveraging dual AMD EPYC™ processors and 12 LFF bays for flexible storage tiers, this solution consolidates 50+ virtual machines per node, cuts hardware sprawl by 70%, and lowers total cost of ownership through improved resource utilization and centralized management.
High-Performance Database and ERP Infrastructure
A financial services firm implements the P14280-B21-HPE ProLiant DL385 Gen10 Plus 12 LFF CTO Server as its primary Oracle and SAP HANA platform. With sub-millisecond I/O response, up to 4 TB of memory, hardware root of trust and custom 12 LFF storage, the server delivers predictable transaction throughput, ensures 99.99% application availability and accelerates daily close by 40%.
Scalable Analytics, AI Inference and Big Data Processing
A research lab scales its AI training and inference pipelines on a cluster of P14280-B21-HPE ProLiant DL385 Gen10 Plus 12 LFF CTO Servers. Combining AMD EPYC cores, optional NVIDIA GPUs and up to 144 TB of direct-attached storage, the platform powers large-scale Hadoop and TensorFlow workloads, reducing model training time by 60% while maintaining secure data sovereignty and edge-ready deployment flexibility.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table
 P14280-B21 |  P07594-B21 |  P14281-B21 |  P14278-B21 |  P14279-B21 | |
|---|---|---|---|---|---|
| CPU Socket | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 |
| Cooling | Active | Active | Active | Active | Active |
| Depth | 28.0 inches | 28 | 28 inches | 28 inches | 28.0 inches |
| Drive Bay Size | 3.5-inch | 3.5-inch | 3.5-inch | 2.5-inch | 3.5-inch |
| Form Factor | Rackmount | Rackmount | Rackmount | Rackmount | Rackmount |
| GPU Support | No | Yes | Yes | Yes | No |
| Height | 3.5 inches | 3.5 | 3.5 inches | 3.5 inches | 3.5 inches |
| Hot-Swap Support | Yes | Yes | Yes | Yes | Yes |
| LAN Ports | 2 | 2 | 2 | 2 | 2 |
| Max Cores per CPU | 32 | 32 | 32 | 32 | 32 |
| Max RAM Capacity | 512 GB | 1 TB | 512 GB | 512 GB | 2 TB |
| Max Threads per CPU | 64 | 64 | 64 | 64 | 64 |
| Network Interface | 1GbE | 10GbE | 10GbE | 10GbE | 10GbE |
| Operating System | Windows Server | Windows Server / VMware ESXi / Ubuntu | Windows Server / VMware ESXi / Ubuntu | Windows Server | Windows Server |
| PCIe Slots | 4 | 4 | 4 | 6 | 4 |
| PCIe Version | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 |
| Power Supply | Redundant | Redundant | Redundant | Redundant | Redundant |
| Power Supply Wattage | 750W | 800W | 800W | 750W | 750W |
| Processor Brand | Intel | Intel | Intel | Intel | Intel |
| Processor Generation | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 4th Gen | Xeon 3rd Gen | Xeon 4th Gen |
| Processor Series | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable |
| Product Name | P14280-B21 | P07594-B21 | P14281-B21 High-Performance Rackmount Server | P14278-B21 | P14279-B21 |
| Product Type | Server | Server | Server | Server | Server |
| RAID Support | RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 10 | RAID 5 / RAID 10 | RAID 10 | RAID 0/1/5/10 |
| RAM Slots | 8 | 16 | 16 | 8 | 16 |
| RAM Type | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 |
| Rack Units | 2U | 2U | 2U | 2U | 2U |
| Rail Kit Included | N/A | N/A | Yes | N/A | Yes |
| Remote Management | iDRAC | iDRAC | iDRAC | iDRAC | iDRAC |
| Scalability | 2P | 2P | 2P | 2P | 2P |
| Storage Bays | 10 | 8 | 8 | 8 | 8 |
| Storage Type | SATA HDD | SATA HDD | SATA SSD | SATA SSD | SATA SSD |
| Use Case | Virtualization | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server | Virtualization | Virtualization |
| Virtualization Ready | Yes | Yes | Yes | Yes | Yes |
| Weight | 50 lbs | 35 lbs | 75 lbs | 45 lbs | 45 lbs |
| Width | 17.2 inches | 17 | 17.5 inches | 17.3 inches | 17.3 inches |
Reviews & Ratings
H
Hassan Riaz
4
Stable with multiple drive configurations.
O
Olof Svensson
5
Good airflow and build quality.
C
Chris Parker
3
Reliable enterprise server.
A
Andres Mejia
4
Consistent uptime.
Questions & Answers
What are the key specifications of the HPE ProLiant DL385 Gen10 Plus 12 LFF CTO Server?
The HPE ProLiant DL385 Gen10 Plus CTO features dual AMD EPYC processors, up to 4 TB DDR4 memory, 12 LFF drive bays, HPE Smart Array controller, flexible networking via FlexibleLOM, and HPE Integrated Lights-Out (iLO) 5 management.
Which processors does the HPE ProLiant DL385 Gen10 Plus support?
It supports dual AMD EPYC 7002 and 7003 Series CPUs with up to 64 cores per socket, delivering high-performance compute for demanding workloads.
What is the maximum memory capacity and type supported?
The server supports up to 4 TB of DDR4 SmartMemory across 16 DIMM slots, with speeds up to 3200 MT/s to optimize performance and reliability.
How many drive bays does this server offer and what drive types can be installed?
It offers 12 large form factor (3.5") bays supporting SAS, SATA, and NVMe drives, enabling flexible and high-capacity storage configurations.