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878614-B21
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HPE ProLiant DL385 Gen10 CTO Mod-X 12 Large Form Factor Serv...
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878614-B21
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- HPE ProLiant DL385 Gen10 CTO Mod-X 12 Large Form Factor Server
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878614-B21 Overview
878614-B21 is a high performance rackmount server engineered to support Intel Xeon Scalable processors compatible with the LGA 4189 socket, offering dual-processor (2P) scalability. It is equipped with ECC DDR4 memory supporting up to 1 TB across 16 DIMM slots, features multiple expansion slots, and incorporates 8 storage bays designed for 2.5-inch drives with hot-swap capability and RAID 10 support.
The server delivers robust network connectivity with 10GbE interfaces over 4 LAN ports, redundant 1200W power supplies, and active cooling for consistent thermal management. With integrated remote management via iDRAC, it supports VMware ESXi and is ideally suited for data center virtualization, file serving, and application server environments.
878614-B21 price is is available on request. Get immediate quote.
Request bulk order quote for 878614-B21 for additional pricing. Browse the full Hpe Proliant Dl385 Gen10 Servers series or explore all Hpe products.
878614-B21 Specifications
- Width
- 17
- Depth
- 28
- Height
- 3.5
- Form Factor
- Rackmount
- PCIe Version
- PCIe 4.0
- RAID Support
- RAID 10
- CPU Socket
- LGA 4189
- Product Type
- Server
- Rack Units
- 2U
- Processor Brand
- Intel
- Processor Series
- Intel Xeon Scalable
- Processor Generation
- Xeon 4th Gen
- Scalability
- 2P
- Max Cores per CPU
- 32
- Max Threads per CPU
- 64
- RAM Type
- ECC DDR4
- RAM Slots
- 16
- Storage Bays
- 8
- Hot-Swap Support
- Yes
- PCIe Slots
- 4
- Network Interface
- 10GbE
- Remote Management
- iDRAC
- Power Supply
- Redundant
- Power Supply Wattage
- 1200W
- Cooling
- Active
- Virtualization Ready
- Yes
- GPU Support
- Yes
- Rail Kit Included
- N/A
- Drive Bay Size
- 2.5-inch
- Operating System
- VMware ESXi
- Max RAM Capacity
- 1 TB
- LAN Ports
- 4
- Weight
- 45
- Storage Type
- NVMe SSD
- Use Case
- Virtualization / File Server / Application Server
- Product Name
- 878614-B21 High Performance Rack Server
878614-B21 Use Case
Enterprise Virtualization Consolidation with HPE ProLiant DL385 Gen10
Scenario: A global financial services firm consolidates 300+ legacy x86 servers onto a private VMware ESXi cluster powered by 878614-B21-HPE ProLiant DL385 Gen10 CTO Mod-X 12 Large Form Factor servers with dual AMD EPYC™ processors and high-density memory. Outcome: Achieved 4× higher VM density, reduced data center power consumption by 30%, centralized management for streamlined operations, and delivered a 25% improvement in overall infrastructure ROI.
Real-Time Business Analytics and High-Performance Databases
Scenario: A retail enterprise deploys 878614-B21-HPE ProLiant DL385 Gen10 CTO Mod-X 12 Large Form Factor servers to run mission-critical SQL and NoSQL databases alongside in-memory analytics for personalized customer experiences. Outcome: Enabled sub-second query performance, accelerated data ingest rates by 25%, improved decision-making agility, and drove a 15% uplift in online sales through real-time insights.
Accelerated Engineering Simulations and High-Performance Computing
Scenario: An automotive OEM operates a private HPC cluster of 878614-B21-HPE ProLiant DL385 Gen10 CTO Mod-X 12 Large Form Factor servers to execute CFD and FEA workloads, leveraging AMD EPYC™ multi-core parallelism and large onboard memory. Outcome: Delivered 3× faster simulation throughput, halved model iteration times, reduced engineering development cycles by 40%, and accelerated time-to-market for new vehicle designs.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table 
| 878614-B21 |  878714-B21 |  P00326-S01 |  878722-B21 |  P00323-S01 | |
|---|---|---|---|---|---|
| CPU Socket | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 | LGA 4189 |
| Cooling | Active | Active | Active | Active | Active |
| Depth | 28 | 28 inches | 27 inches | 28 | 28.0 inches |
| Drive Bay Size | 2.5-inch | 2.5-inch | Mixed | 3.5-inch | 2.5-inch |
| Form Factor | Rackmount | Rackmount | Rackmount | Rackmount | Rackmount |
| GPU Support | Yes | Yes | Yes | Yes | No |
| Height | 3.5 | 3.5 inches | 3.5 inches | 3.5 | 3.5 inches |
| Hot-Swap Support | Yes | Yes | Yes | Yes | Yes |
| LAN Ports | 4 | 2 | 4 | 2 | 4 |
| Max Cores per CPU | 32 | 32 | 32 | 64 | 32 |
| Max RAM Capacity | 1 TB | 1 TB | 512 GB | 1 TB | 512 GB |
| Max Threads per CPU | 64 | 64 | 64 | 128 | 64 |
| Network Interface | 10GbE | 10GbE | 10GbE | 10GbE | 1GbE |
| Operating System | VMware ESXi | Windows Server | Windows Server / VMware ESXi / Ubuntu | Windows Server / VMware ESXi / Ubuntu | Windows Server |
| PCIe Slots | 4 | 4 | 4 | 4 | 4 |
| PCIe Version | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 |
| Power Supply | Redundant | Redundant | Redundant | Redundant | Redundant |
| Power Supply Wattage | 1200W | 1000W | 750W | 1000W | 750W |
| Processor Brand | Intel | Intel | Intel | Intel | Intel |
| Processor Generation | Xeon 4th Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 3rd Gen |
| Processor Series | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable |
| Product Name | 878614-B21 High Performance Rack Server | 878714-B21 | P00326-S01 Enterprise Server | 878722-B21 | P00323-S01 High Performance Rackmount Server |
| Product Type | Server | Server | Server | Server | Server |
| RAID Support | RAID 10 | RAID 5 | RAID 0 / RAID 1 / RAID 5 | RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10 | RAID 0 / RAID 1 / RAID 5 / RAID 10 |
| RAM Slots | 16 | 16 | 8 | 16 | 16 |
| RAM Type | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 |
| Rack Units | 2U | 2U | 2U | 2U | 2U |
| Rail Kit Included | N/A | N/A | N/A | No | Yes |
| Remote Management | iDRAC | iDRAC | iDRAC | iDRAC | iDRAC |
| Scalability | 2P | 2P | 2P | 2P | 2P |
| Storage Bays | 8 | 8 | 6 | 12 | 8 |
| Storage Type | NVMe SSD | SATA SSD | SATA SSD | Hybrid | SATA SSD |
| Use Case | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server / Data Center | Virtualization |
| Virtualization Ready | Yes | Yes | Yes | Yes | Yes |
| Weight | 45 | 45 lbs | 50 lbs | 45 | 45 lbs |
| Width | 17 | 19 inches | 19 inches | 17.3 | 17.0 inches |
Reviews & Ratings
N
Noman Javed
4
Stable platform for storage heavy workloads.
S
Stefan Braun
4
Cooling remains effective under load.
A
Andrew Cole
5
Easy to customize.
I
Irfan Shah
5
Consistent enterprise reliability.
Questions & Answers
What are the key specifications of the HPE ProLiant DL385 Gen10 CTO Mod-X 12 Large Form Factor Server?
The HPE ProLiant DL385 Gen10 CTO Mod-X 12 LFF offers dual-socket AMD EPYC support, up to 3 TB DDR4 memory, 12 large form factor drive bays, integrated HPE iLO 5 management and flexible networking options.
Which processors are supported by the DL385 Gen10 CTO Mod-X 12 server?
This server supports 2nd and 3rd Gen AMD EPYC processors with up to 64 cores per socket, delivering high performance for virtualization, databases and HPC workloads.
How much memory can the DL385 Gen10 CTO Mod-X 12 accommodate?
The system offers 16 DIMM slots and supports up to 3 TB of DDR4 ECC RDIMM memory at speeds up to 3200 MT/s for heavy-memory applications.
What storage options are available in the 12-bay large form factor chassis?
You can install up to twelve 3.5″ SAS, SATA or nearline SAS drives, plus optional NVMe adapters, delivering up to 96 TB raw capacity and flexible tiering.
Can I upgrade the drive bays on the DL385 Gen10 CTO Mod-X 12?
Yes. The modular drive cage supports hot-swap LFF drives and can be upgraded with optional NVMe or SATA controllers to meet evolving performance needs.
What management and monitoring tools are integrated?
HPE iLO 5 provides remote management, OneView for unified infrastructure control and HPE InfoSight for AI-driven predictive analytics and proactive support.
Is the DL385 Gen10 suitable for virtualization deployments?
Absolutely. With dual AMD EPYC processors, large memory capacity and high I/O bandwidth, it delivers robust performance for VMware ESXi, Microsoft Hyper-V and KVM environments.
How does the server ensure data security and compliance?
It includes HPE Silicon Root of Trust, Secure Boot, TPM 2.0 and Secure Encryption options, safeguarding firmware integrity and encrypting data at rest.
What networking connectivity options are supported?
Built-in FlexibleLOM supports 25/10/1 GbE and optional 100 GbE adapters. PCIe Gen4 slots allow further NIC expansion for high-density networking.
Which power supply configurations are available?
Choose redundant Platinum or Titanium hot-pluggable power supplies in 800 W, 1600 W or 2000 W to balance efficiency and availability.
What are typical use cases for the DL385 Gen10 CTO Mod-X 12?
Ideal for virtualization, ERP, high-performance database workloads, software-defined storage and edge computing requiring high memory and I/O throughput.
Does this server support GPU acceleration?
Yes. It offers up to three full-height, low-profile GPUs via PCIe Gen4 slots, supporting AI inference, machine learning and GPU-accelerated compute.
How energy efficient is the DL385 Gen10 server?
With HPE Power Discovery Services, Dynamic Power Capping and Titanium-rated PSUs, it delivers industry-leading energy efficiency and lowers TCO.
Which operating systems are compatible with the DL385 Gen10?
Certified for Red Hat Enterprise Linux, SUSE Linux Enterprise Server, VMware ESXi, Microsoft Windows Server and leading cloud hypervisors.
What warranty and support options are offered for this server?
Standard 3-year parts, labor and on-site support is included, with optional HPE Foundation Care, Proactive Care and Datacenter Care upgrades available.
How do I rack-mount the HPE ProLiant DL385 Gen10 CTO Mod-X 12?
Use the included sliding rail kit for 2U installation in a 19″ data center rack, following the Quick Setup Guide for safe mounting and cabling.