Servers HPE Proliant DL385 Gen10
HPE Proliant DL385 Gen10 servers offer unmatched enterprise performance, robust security, scalable virtualization, and efficient management for modern data centers, delivering reliability and cutting-edge computing excellence.
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24 Matching results

P00323-S01 (HPE ProLiant DL385 Gen10 7251 2.1GHz 8-core 1P 16GB-R E208i-a 8SFF SATA 500W PS US Server/S-Buy)
4.4 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 3rd Gen
- Virtualization
Est Value$3,296.96
$1,813.32
45% offFirst-Time Buyer Discount – Get up to 2% additional off on your first order
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878714-B21 (HPE ProLiant DL385 Gen10 7251 1P 16GB-R E208i-a 8SFF SATA 500W PS Entry Server)
4.6 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 3rd Gen
- Virtualization / File Server / Application Server
Est Value$3,931.08
$2,437.27
38% offFirst-Time Buyer Discount – Get up to 2% additional off on your first order
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878716-B21 (HPE ProLiant DL385 Gen10 7251 1P 32GB-R P816i-a 12LFF SATA 800W PS Base Server)
4.2 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 3rd Gen
- Virtualization
Est Value$5,696.45
$2,506.43
56% offFirst-Time Buyer Discount – Get up to 2% additional off on your first order
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878712-B21 (HPE ProLiant DL385 Gen10 7251 1P 16GB-R E208i-a 8LFF SATA 500W PS Entry Server)
5 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 3rd Gen
- Virtualization / File Server / Application Server
Est Value$3,931.08
$3,655.91
7% offFirst-Time Buyer Discount – Get up to 2% additional off on your first order
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878718-B21 (HPE ProLiant DL385 Gen10 7301 1P 32GB-R P408i-a 8SFF SAS 500W PS Base Server)
4.6 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 3rd Gen
- Virtualization
Est Value$5,583.59
$5,192.74
7% offFirst-Time Buyer Discount – Get up to 2% additional off on your first order
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878722-B21 (HPE ProLiant DL385 Gen10 7451 2P 64GB-R P408i-a 8SFF SAS 2x800W PS Perf Server)
4.4 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 3rd Gen
- Virtualization / File Server / Application Server / Data Center
Est Value$14,536.38
$5,959.92
59% offFirst-Time Buyer Discount – Get up to 2% additional off on your first order
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878724-B21 (HPE ProLiant DL385 Gen10 7451 2P 64GB-R P408i-a 24SFF SAS 2x800W PS Perf Server)
4.6 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 3rd Gen
- Virtualization
Est Value$15,262.75
$6,715.61
56% offFirst-Time Buyer Discount – Get up to 2% additional off on your first order
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878720-B21 (HPE ProLiant DL385 Gen10 7401 1P 32GB-R P408i-a 24SFF SAS 800W PS Base Server)
4.4 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 3rd Gen
- Data Center / Virtualization / File Server / Application Server
Est Value$8,045.67
$7,482.47
7% offFirst-Time Buyer Discount – Get up to 2% additional off on your first order
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- BEST SELLING

P11747-B21 (HPE ProLiant DL385 Gen10 7251 2.1GHz 8-core 1P 16GB-R P408i-a 8SFF 500W PS Server)
5 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 3rd Gen
- Virtualization
Est ValueFirst-Time Buyer Discount – Get up to 2% additional off on your first order
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Use eCoupon ORMSAVE10
eCoupon limited to 5 units
- BEST SELLING

P11809-B21 (HPE ProLiant DL385 Gen10 7301 2.2GHz 16-core 1P 32GB-R P408i-a 8SFF 800W PS Server)
4.6 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 4th Gen
- Virtualization / File Server / Application Server
Est ValueFirst-Time Buyer Discount – Get up to 2% additional off on your first order
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P09707-B21 (HPE ProLiant DL385 Gen10 7351 2.4GHz 16-core 1P 32GB-R P408i-a 8SFF 800W PS Solution Server)
4.6 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 3rd Gen
- Virtualization / File Server / Application Server
Est ValueFirst-Time Buyer Discount – Get up to 2% additional off on your first order
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P05887-B21 (HPE ProLiant DL385 Gen10 7251 2.1GHz 8-core 1P 16GB-R P408i-a 8SFF 500W RPS Solution Server)
4.2 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 3rd Gen
- Virtualization
Est ValueFirst-Time Buyer Discount – Get up to 2% additional off on your first order
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P09708-B21 (HPE ProLiant DL385 Gen10 7551 2GHz 32-core 1P 32GB-R P408i-a 8SFF 800W PS Base Server)
4.6 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 3rd Gen
- Virtualization
Est ValueFirst-Time Buyer Discount – Get up to 2% additional off on your first order
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878613-B21 (HPE ProLiant DL385 Gen10 CTO Mod-X 24 Small Form Factor Server)
5 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 3rd Gen
- Virtualization / File Server / Application Server
Est ValueFirst-Time Buyer Discount – Get up to 2% additional off on your first order
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878614-B21 (HPE ProLiant DL385 Gen10 CTO Mod-X 12 Large Form Factor Server)
4.6 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 4th Gen
- Virtualization / File Server / Application Server
Est ValueFirst-Time Buyer Discount – Get up to 2% additional off on your first order
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878612-B21 (HPE ProLiant DL385 Gen10 CTO Mod-X 8 Small Form Factor Server)
4.8 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 4th Gen
- Virtualization / File Server / Application Server
Est ValueFirst-Time Buyer Discount – Get up to 2% additional off on your first order
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878615-B21 (HPE ProLiant DL385 Gen10 CTO Mod-X 8 Large Form Factor Server)
4.6 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 3rd Gen
- Virtualization / File Server / Application Server
Est ValueFirst-Time Buyer Discount – Get up to 2% additional off on your first order
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Use eCoupon ORMSAVE10
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878616-B21 (HPE DL385 Gen10 CTO Mod-X 8SFF TAA Svr Server)
4.6 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 3rd Gen
- Virtualization
Est ValueFirst-Time Buyer Discount – Get up to 2% additional off on your first order
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Use eCoupon ORMSAVE10
eCoupon limited to 5 units

878617-B21 (HPE DL385 Gen10 CTO Mod-X 24SFF TAA Svr Server)
4.8 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 3rd Gen
- Virtualization
Est ValueFirst-Time Buyer Discount – Get up to 2% additional off on your first order
ORM Rewards Earn $50 in Rewards + Free Expedited Delivery – Join Now!
Use eCoupon ORMSAVE10
eCoupon limited to 5 units

878618-B21 (HPE DL385 Gen10 CTO Mod-X 12LFF TAA Svr Server)
4.8 (5)- Server
- Rackmount
- 2U
- Intel
- Intel Xeon Scalable
- Xeon 3rd Gen
- Virtualization
Est ValueFirst-Time Buyer Discount – Get up to 2% additional off on your first order
ORM Rewards Earn $50 in Rewards + Free Expedited Delivery – Join Now!
Use eCoupon ORMSAVE10
eCoupon limited to 5 units

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Questions & Answers
What are the key specifications of the HPE ProLiant DL385 Gen10 Server?
The HPE ProLiant DL385 Gen10 features dual AMD EPYC processors, up to 32 DDR4 DIMM slots (3TB max), eight 2.5″ drive bays, HPE iLO management, and flexible networking options.
Which AMD EPYC processors are supported by the DL385 Gen10?
The DL385 Gen10 supports AMD EPYC 7000- and 7002-series CPUs, delivering up to 64 cores per processor, PCIe 3.0 lanes, and advanced security features for demanding workloads.
How much memory can the DL385 Gen10 server handle?
It supports up to 3 TB of DDR4 memory across 32 DIMM slots with HPE Persistent Memory 100 Series, optimizing performance for virtualization and in-memory databases.
What storage configurations are available on the DL385 Gen10?
Choose from eight 2.5″ or four 3.5″ SAS/SATA drive bays, NVMe options, or HPE Smart Array controllers for RAID up to 12 Gb/s and flexible capacity scaling.
Which networking options does the DL385 Gen10 support?
Built with FlexibleLOM connectors, it supports 1/10/25/40/100 GbE NICs, PCIe 3.0 add-in cards, and optional HPE FlexibleLOM adapters for high-throughput, low-latency Ethernet.
How does HPE iLO enhance server management on the DL385 Gen10?
HPE iLO provides remote monitoring, firmware updates, Power Management, and automated diagnostics through a secure web interface or RESTful API, boosting uptime and efficiency.
What virtualization platforms are certified on the DL385 Gen10?
The server is certified for VMware vSphere, Microsoft Hyper-V, Red Hat Enterprise Virtualization, Citrix Hypervisor, and Nutanix AHV, ensuring wide compatibility and stability.
How energy-efficient is the HPE ProLiant DL385 Gen10?
Featuring HPE Flexible Slot Power Supplies (up to 96% efficiency), intelligent cooling, and Dynamic Power Capping, it reduces data center power draw and operational costs.
Can the DL385 Gen10 be integrated into HPE Synergy or OneView environments?
Yes. With HPE OneView and Synergy integration, it supports unified resource pools, automated provisioning, and firmware compliance across physical and composable infrastructures.
What security features are included on the DL385 Gen10?
Security features include silicon root of trust, secure recovery, runtime firmware validation, TPM 2.0, and Secure Boot to protect firmware and server integrity.
How do I upgrade from a Gen9 to a Gen10 DL385?
Upgrade by migrating to AMD EPYC CPUs, installing new DDR4 DIMMs, updating HPE iLO firmware, and adopting Gen10 drive carriers and optional NVMe modules.
What warranty and support options are available for the DL385 Gen10?
HPE offers a one-year parts, labor, and travel warranty, upgradable to 3–5 years with HPE Foundation Care or HPE Proactive Care for enhanced coverage.
What are typical use cases for the DL385 Gen10 Server?
Ideal for virtualization, big data analytics, database clustering, high-performance computing, AI inference, and mixed-workload consolidation in enterprise and edge deployments.
How do I configure RAID on the DL385 Gen10?
Use the HPE Smart Array S100i or optional HPE Smart Array controllers via HPE Smart Storage Administrator to create RAID 0/1/5/6/10 arrays with online capacity expansion.
What makes the DL385 Gen10 suitable for AI and GPU workloads?
It supports up to three double-wide GPUs or four single-wide GPUs with GPU kits, offering power delivery and cooling for NVIDIA and AMD accelerators in a 2U chassis.