United States$5,000,000+
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Thomas Fairchild
5
Dual processor configuration delivers excellent compute capacity.
878722-B21
HPE ProLiant DL385 Gen10 7451 2P 64GB-R P408i-a 8SFF SAS 2x8...
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878722-B21
- Description:
- HPE ProLiant DL385 Gen10 7451 2P 64GB-R P408i-a 8SFF SAS 2x800W PS Perf Server
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- List Price:
$14,536.38
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878722-B21 Overview
878722-B21 is a high-performance rackmount server engineered to deliver robust computing power using Intel Xeon Scalable processors on an LGA 4189 socket, configured in a two-processor (2P) setup. It supports ECC DDR4 memory with up to 1 TB capacity across 16 slots, offers four PCIe 4.0 expansion slots, and features 12 hot-swap 3.5-inch storage bays with full RAID support (RAID 0, RAID 1, RAID 5, RAID 6, RAID 10), making it well-suited for virtualization, file serving, and application hosting in data center environments.
With dual 10GbE network interfaces, a redundant 1000W power supply, active cooling, and integrated iDRAC remote management, the 878722-B21 is optimized for demanding workloads. It supports major operating systems such as Windows Server, VMware ESXi, and Ubuntu, positioning it as an ideal solution for data center deployments, cloud hosting, and other mission-critical IT applications.
878722-B21 price is $5,959.92, a 59% saving from the Hpe list price of $14,536.38. 878722-B21 is in stock and available for next-day dispatch. (terms applied)
Request bulk order quote for 878722-B21 for additional pricing. Browse the full Hpe Proliant Dl385 Gen10 Servers series or explore all Hpe products.
878722-B21 Specifications
- Product Type
- Server
- Form Factor
- Rackmount
- Rack Units
- 2U
- Processor Brand
- Intel
- Processor Series
- Intel Xeon Scalable
- Processor Generation
- Xeon 3rd Gen
- Use Case
- Virtualization / File Server / Application Server / Data Center
- CPU Socket
- LGA 4189
- Scalability
- 2P
- Max Cores per CPU
- 64
- Max Threads per CPU
- 128
- RAM Type
- ECC DDR4
- RAM Slots
- 16
- Max RAM Capacity
- 1 TB
- Storage Type
- Hybrid
- Storage Bays
- 12
- Drive Bay Size
- 3.5-inch
- Hot-Swap Support
- Yes
- RAID Support
- RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10
- PCIe Slots
- 4
- PCIe Version
- PCIe 4.0
- Network Interface
- 10GbE
- LAN Ports
- 2
- Remote Management
- iDRAC
- Power Supply
- Redundant
- Power Supply Wattage
- 1000W
- Cooling
- Active
- Operating System
- Windows Server / VMware ESXi / Ubuntu
- Virtualization Ready
- Yes
- GPU Support
- Yes
- Rail Kit Included
- No
- Product Name
- 878722-B21
- Height
- 3.5
- Width
- 17.3
- Depth
- 28
- Weight
- 45
878722-B21 Use Case
Virtual Infrastructure Consolidation with HPE ProLiant DL385 Gen10 878722-B21
A mid-sized financial institution consolidated 120 VMware ESXi VMs onto the HPE ProLiant DL385 Gen10 878722-B21 (AMD EPYC 7451 2P, 64 GB-R) server, reducing rack density by 60% and cutting power consumption by 30%. The deployment delivered a 3× increase in VM density and a 25% reduction in TCO.
High-Performance Data Analytics on HPE ProLiant DL385 Gen10 878722-B21
A retail analytics provider uses the HPE ProLiant DL385 Gen10 878722-B21 server (P408i-a 8-SFF SAS, 2×800 W PS) to accelerate SAP HANA in-memory processing for 1 TB transactional datasets. The solution achieved sub-second query times and 50% faster report generation, driving real-time insights and revenue growth.
Secure VDI Deployment with HPE ProLiant DL385 Gen10 878722-B21
A healthcare organization deploys 200 virtual desktops on the HPE ProLiant DL385 Gen10 878722-B21 server (AMD EPYC 7451, 64 GB-R) to support EMR access with 99.99% uptime. Integrated HPE iLO management and P408i-a RAID deliver a 35% reduction in provisioning time and enforce stringent data-security compliance.
Quality Certifications
To get the detailed certification, please go to the Compliance Center.
Product Comparison Table 
 878722-B21 |  P00324-S01 |  P11809-B21 |  878614-B21 |  878720-B21 | |
|---|---|---|---|---|---|
| CPU Socket | LGA 4189 | LGA 4189 | LGA 4677 | LGA 4189 | LGA 4189 |
| Cooling | Active | Active | Active | Active | Active |
| Depth | 28 | 27.5 inches | 28 inches | 28 | 29.53 |
| Drive Bay Size | 3.5-inch | 3.5-inch | Mixed | 2.5-inch | 3.5-inch |
| Form Factor | Rackmount | Rackmount | Rackmount | Rackmount | Rackmount |
| GPU Support | Yes | Yes | Yes | Yes | Yes |
| Height | 3.5 | 3.5 inches | 3.5 inches | 3.5 | 3.44 |
| Hot-Swap Support | Yes | Yes | Yes | Yes | Yes |
| LAN Ports | 2 | 4 | 4 | 4 | 2 |
| Max Cores per CPU | 64 | 32 | 32 | 32 | 32 |
| Max RAM Capacity | 1 TB | 512 GB | 1 TB | 1 TB | 1 TB |
| Max Threads per CPU | 128 | 64 | 64 | 64 | 64 |
| Network Interface | 10GbE | 10GbE | 10GbE | 10GbE | 10GbE |
| Operating System | Windows Server / VMware ESXi / Ubuntu | Windows Server / VMware ESXi / Ubuntu | VMware ESXi | VMware ESXi | Windows Server |
| PCIe Slots | 4 | 4 | 6 | 4 | 4 |
| PCIe Version | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 | PCIe 4.0 |
| Power Supply | Redundant | Redundant | Redundant | Redundant | Redundant |
| Power Supply Wattage | 1000W | 750W | 1200W | 1200W | 800W |
| Processor Brand | Intel | Intel | Intel | Intel | Intel |
| Processor Generation | Xeon 3rd Gen | Xeon 3rd Gen | Xeon 4th Gen | Xeon 4th Gen | Xeon 3rd Gen |
| Processor Series | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable | Intel Xeon Scalable |
| Product Name | 878722-B21 | P00324-S01 | P11809-B21 Enterprise Rack Server | 878614-B21 High Performance Rack Server | 878720-B21 Enterprise Rackmount Server |
| Product Type | Server | Server | Server | Server | Server |
| RAID Support | RAID 0 / RAID 1 / RAID 5 / RAID 6 / RAID 10 | RAID 10 | RAID 10 | RAID 10 | RAID 5 |
| RAM Slots | 16 | 16 | 16 | 16 | 16 |
| RAM Type | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 | ECC DDR4 |
| Rack Units | 2U | 2U | 2U | 2U | 2U |
| Rail Kit Included | No | No | N/A | N/A | Yes |
| Remote Management | iDRAC | iDRAC | iDRAC | iDRAC | iDRAC |
| Scalability | 2P | 2P | 2P | 2P | 2P |
| Storage Bays | 12 | 8 | 8 | 8 | 8 |
| Storage Type | Hybrid | SATA HDD | Hybrid | NVMe SSD | SATA HDD |
| Use Case | Virtualization / File Server / Application Server / Data Center | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server | Virtualization / File Server / Application Server | Data Center / Virtualization / File Server / Application Server |
| Virtualization Ready | Yes | Yes | Yes | Yes | Yes |
| Weight | 45 | 65 lbs | 50 lbs | 45 | 38 lbs |
| Width | 17.3 | 17.3 inches | 17.2 inches | 17 | 17.32 |
Reviews & Ratings
A
Ammar Raza
4
Handles virtualization clusters smoothly.
G
Giuseppe Romano
5
Strong stability under sustained workloads.
H
Henry Lawson
4
Enterprise ready power and cooling.
I
Imran Qureshi
4
Meets high performance expectations.
Questions & Answers
What is the HPE ProLiant DL385 Gen10 7451 (SKU 878722-B21)?
The HPE ProLiant DL385 Gen10 7451 (SKU 878722-B21) is a 2-socket, 2U rack server powered by AMD EPYC™ processors, designed for performance-intensive workloads in virtualized and data-center environments.
Which processors are installed in the DL385 Gen10 7451 server?
This server is equipped with dual AMD EPYC 7451 2.3 GHz processors, offering 24 cores each and up to 48 MB L3 cache per CPU for high parallel compute performance.
How much memory does the HPE ProLiant DL385 Gen10 include?
The DL385 Gen10 ships with 64 GB of DDR4 RDIMM memory (4×16 GB modules) at 2666 MT/s and supports up to 3 TB using 24 DIMM slots.
What storage options are available on the DL385 Gen10 SKU 878722-B21?
It supports up to eight 2.5-inch SFF SAS drives with a hardware RAID controller, delivering flexible capacity and enterprise-class data protection.
Which RAID controller is preinstalled on this server?
The server includes an HPE Smart Array P408i-a SR Gen10 12 Gb/s SAS RAID controller with 2 GB cache, supporting RAID 0,1,5,6,10,50,60 for optimized storage performance.
What power supplies come with the DL385 Gen10 7451 server?
It is configured with two hot-plug, redundant 800 W Platinum-rated power supplies, ensuring 94% efficiency and high availability in critical environments.
Does the DL385 Gen10 support integrated remote management?
Yes, it features HPE Integrated Lights-Out (iLO) 5 for secure remote management, firmware updates, health monitoring, and automated alerting.
What network connectivity options are provided?
Out of the box, it offers four 1 GbE FlexibleLOM ports, with optional add-on NICs supporting 10/25/40/100 GbE to meet demanding network throughput requirements.
Which operating systems are compatible with this server?
The DL385 Gen10 is certified for Microsoft Windows Server, Red Hat and SUSE Linux Enterprise, VMware ESXi, and major Linux distributions for maximum interoperability.
What are the ideal use cases for the ProLiant DL385 Gen10 7451?
This server excels in virtualization, database workloads, big data analytics, and high-performance computing thanks to its high core count, memory capacity, and IO flexibility.
What is the form factor and rack mounting specification?
The DL385 Gen10 is a 2U rack-mountable server designed for a standard 19-inch rack, with tool-less rail kits available for quick installation.
How scalable is the memory and storage expansion?
You can expand memory up to 3 TB across 24 DIMM slots and add up to 8 additional NVMe drives or 16 SAS/SATA drives via optional drive cages and mezzanine cards.
What security features are included on the DL385 Gen10?
Built-in silicon root of trust, Secure Boot, and Runtime Firmware Validation protect against firmware attacks, while TPM 2.0 provides hardware-based encryption keys.
What energy-efficiency certifications does this server have?
The server holds ENERGY STAR® certification and leverages HPE Power Discovery Services and dynamic power capping for optimized energy consumption.
What warranty and support options are available?
Your purchase includes a standard 3-year limited warranty with next-business-day hardware replacement, upgradeable to HPE Foundation Care and Mission Critical Service levels.
How can I configure or upgrade the HPE ProLiant DL385 Gen10 7451?
Use HPE’s online QuickSpecs or HPE PartSurfer to select additional memory, storage, NICs, or GPU options, then order through HPE authorized resellers or the HPE Quick Ordering Guide.