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ISR4351/K9

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200Mbps-400Mbps system throughput, 3 WAN/LAN ports, 3 SFP ports, multi-Core CPU,2 service module slots, Security, Voice, WAAS, Intelligrnt WAN, OnePK, AVC
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ISR4351/K9

200Mbps-400Mbps system throughput, 3 WAN/LAN ports...

$12,775.00

$1,773.00

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$1,773.00

86% off

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ISR4351/K9 Use Case

Hybrid WAN Optimization for Distributed Retail Branches

In a global retail chain, the Cisco ISR4351/K9’s 200 Mbps–400 Mbps system throughput, 3 WAN/LAN ports and Intelligent WAN (IWAN) aggregate MPLS, broadband and LTE links to deliver high-availability POS and inventory services. Its multi-core CPU and Application Visibility and Control (AVC) dynamically prioritize checkout and ERP traffic, while WAAS modules accelerate cloud-based promotions. Security services and OnePK APIs enforce consistent policy across sites. Outcome: 40% faster transactions, 30% lower WAN costs and 99.9% branch uptime.

Unified Voice and Secure Communications in Financial Services

A mid-size bank leverages the Cisco ISR4351/K9 with 2 service-module slots populated by voice DSP and security modules, plus 3 SFP fiber ports for redundant data center uplinks. The multi-core CPU sustains simultaneous encryption, voice transcoding and firewall throughput up to 400 Mbps, while AVC and QoS guarantee sub-50 ms call latency. OnePK automation streamlines provisioning and compliance auditing under PCI DSS. Outcome: 99.99% voice uptime, 50% reduction in call drops and robust regulatory compliance.

Secure High-Performance Cloud Edge for Healthcare Networks

A regional hospital deploys Cisco ISR4351/K9 routers at its data centers and clinics to support secure EHR access and telemedicine. Utilizing 3 WAN/LAN ports, 3 SFP ports and Intelligent WAN, clinicians gain resilient, low-latency connectivity to SaaS and EMR platforms. WAAS accelerates patient records, service modules enforce next-gen firewall and encryption, and AVC monitors critical medical applications. Outcome: 25% faster EHR response times, full HIPAA compliance and simplified network management through OnePK orchestration.

Product Comparison Table

Cisco ISR 4221 (2GE,2NIM,8G FLASH,8G DRAM,IPB)
ISR4221X/K9

200Mbps-400Mbps system throughput, 3 WAN/LAN ports, 3 SFP ports, multi-Core CPU,2 service module slots, Security, Voice, WAAS, Intelligrnt WAN, OnePK, AVC
ISR4351/K9

Cisco ISR 4451 AXV Bundle.PVDM4-64 w/APP.SEC.UC lic.CUBE-25
ISR4451-X-AXV/K9

Cisco ISR 4321 AXV Bundle, with CUBE-10, IPBase, APP, SEC and UC licenses.
ISR4321-AXV/K9

Cisco ISR 4461 with AppX license
ISR4461-AX/K9

5G Support No No No No No
Architecture Fixed Fixed Modular Fixed Fixed
Broadband N/A N/A N/A N/A N/A
Built-in Security Features Firewall / Intrusion Prevention / Malware Protection Firewall / Intrusion Prevention / Malware Protection Firewall / Intrusion Prevention / Malware Protection Firewall / Intrusion Prevention / Malware Protection Firewall, Intrusion Prevention, Malware Protection
Compliance Standards FCC / CE / RoHS FCC / CE / RoHS FCC / CE / UL FCC, CE FCC, CE, RoHS
Connectivity Type Wired Wired / Ethernet Wired Wired Wired / Wireless / Ethernet
Depth N/A 18.8 inches N/A 18.3 inches N/A
Device Type Router Router Router Router Router
EMC EN 55032 / EN 55024 N/A FCC C63.10 CISPR22, FCC Part 15 N/A
Ethernet Technology 10/100/1000 10/100/1000 10/100/1000 10/100/1000 10/100/1000
Expansion Slots EHWIC / NIM EHWIC / NIM EHWIC / NIM NIM / EHWIC EHWIC, NIM
Features VPN / Firewall / IPv6 Compatible VPN / VoIP / IPv6 Compatible / Firewall / MPLS VPN / VoIP / IPv6 Compatible / Firewall / MPLS Mesh / VPN / VoIP / IPv6 Compatible / Firewall / MPLS VPN, Voice, Video, IPv6 Compatible, Firewall, POE, Integrated Services
Firewall Features Yes Yes Yes Yes Yes
Flash Memory 256 MB 2 GB 1 GB 256 MB 1 GB
Form Factor Desktop Rack-mount Rack-mount Chassis Rack-mount / Desktop Rack-mount
Height N/A 1.73 inches N/A 1.75 inches N/A
High Availability Support Supported Supported Supported Supported Supported
Integrated Services Voice / Video / WAN Optimization Voice / Video Voice / Video / WAN Optimization Voice / Video / WAN Optimization Voice, Video, WAN Optimization
Interface Ports RJ-45 RJ-45 RJ-45 / SFP RJ-45 / SFP RJ-45, SFP, Combo Ports
LAN Ports 4 LAN Ports 4 LAN Ports 4 LAN Ports 4 LAN Ports 4 LAN Ports
Management Managed Managed Managed Managed Managed
Memory 4 GB 4 GB 4 GB 512 MB 4 GB
Modular Slots Available 2 Slots 3+ Slots 3+ Slots 2 Slots 2 Slots
Network Protocols IPv4 / IPv6 IPv4 / IPv6 IPv4 / IPv6 IPv4, IPv6 OSPF, BGP, EIGRP, RIP, Static Routing
Power 65W 60 Watt 305 W 54 W 350 W
Power Source AC Power Supply / DC Power Supply / Redundant AC Power Supply / DC Power Supply / Redundant / N/A Redundant AC Power Supply AC Power Supply / Redundant AC Power Supply with Redundant Option
Product Name Cisco ISR 4221 Integrated Services Router Cisco ISR 4351-K9 Integrated Services Router Cisco ISR4451-X Integrated Services Router Cisco ISR4321-AXV/K9 ISR4461-AX/K9
Product Type Enterprise Router Enterprise Router Enterprise Router Enterprise Router Enterprise Router
QoS Features Supported Supported Supported Supported Supported
Remote Management SSH / Telnet / SNMP SSH / Telnet / SNMP CLI / SNMP / NetFlow SSH, Telnet, SNMP CLI, HTTP, SNMP
Routing Protocols OSPF / BGP / EIGRP / RIP / Static Routing OSPF / BGP / EIGRP / MPLS / IS-IS / RIP / Static Routing / N/A OSPF / BGP / EIGRP / MPLS / RIP / Static Routing OSPF / BGP / EIGRP / MPLS / IS-IS / RIP / Static Routing OSPF / BGP / EIGRP / RIP / Static Routing
Safety UL / CUL N/A RoHS RoHS Compliant N/A
Speed/Capacity Gigabit Gigabit Gigabit Gigabit Gigabit
Stacking Capability No No Yes Yes Yes
Telecom ITU-T N/A FCC Part 15 TIA/EIA N/A
Throughput Capacity 300 Mbps 75 Mbps 2 Gbps 200 Mbps 1 Gbps
Use Case Business Enterprise Enterprise Enterprise / Branch Enterprise / Branch Office
VPN Support IPSec / SSL VPN / DMVPN / FlexVPN IPSec / SSL VPN / GRE / DMVPN / FlexVPN / N/A IPSec / SSL VPN / DMVPN / FlexVPN / N/A IPSec / SSL VPN / DMVPN / FlexVPN IPSec / SSL VPN / DMVPN / FlexVPN / N/A
WAN Configuration Dual WAN Dual WAN Dual WAN Dual WAN Dual WAN
WAN Ports 2 WAN 2 WAN 2 WAN 2 WAN 2 WAN
Weight N/A 15 lbs N/A 13.2 lbs N/A
Wi-Fi Standard N/A N/A N/A N/A WiFi 6 (802.11ax)
Width N/A 17.3 inches N/A 17.5 inches N/A
Wireless Support No No No No Yes

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